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Discovery of Disubstituted Imidazo[4,5-b]pyridines and Purines as Potent TrkA Inhibitors.

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Title: Discovery of Disubstituted Imidazo[4,5-b]pyridines and Purines as Potent TrkA Inhibitors.
Authors: Wang T; Oncology Innovative Medicines Unit, AstraZeneca R&D Boston , 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Lamb ML; Oncology Innovative Medicines Unit, AstraZeneca R&D Boston , 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Block MH; Oncology Innovative Medicines Unit, AstraZeneca R&D Boston , 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Davies AM; Oncology Innovative Medicines Unit, AstraZeneca R&D Boston , 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Han Y; Array BioPharma Inc. , 3200 Walnut Street, Boulder, Colorado 80301, United States., Hoffmann E; Oncology Innovative Medicines Unit, AstraZeneca R&D Boston , 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Ioannidis S; Oncology Innovative Medicines Unit, AstraZeneca R&D Boston , 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Josey JA; Array BioPharma Inc. , 3200 Walnut Street, Boulder, Colorado 80301, United States., Liu ZY; Oncology Innovative Medicines Unit, AstraZeneca R&D Boston , 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Lyne PD; Oncology Innovative Medicines Unit, AstraZeneca R&D Boston , 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., MacIntyre T; Oncology Innovative Medicines Unit, AstraZeneca R&D Boston , 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Mohr PJ; Array BioPharma Inc. , 3200 Walnut Street, Boulder, Colorado 80301, United States., Omer CA; Oncology Innovative Medicines Unit, AstraZeneca R&D Boston , 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Sjögren T; Discovery Sciences, Innovative Medicines, AstraZeneca , Pepparedsleden S431 83 Mölndal, Sweden., Thress K; Oncology Innovative Medicines Unit, AstraZeneca R&D Boston , 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Wang B; Array BioPharma Inc. , 3200 Walnut Street, Boulder, Colorado 80301, United States., Wang H; Oncology Innovative Medicines Unit, AstraZeneca R&D Boston , 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Yu D; Oncology Innovative Medicines Unit, AstraZeneca R&D Boston , 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Zhang HJ; Oncology Innovative Medicines Unit, AstraZeneca R&D Boston , 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2012 Jul 26; Vol. 3 (9), pp. 705-9. Date of Electronic Publication: 2012 Jul 26 (Print Publication: 2012).
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Discovery of Disubstituted Imidazo[4,5-b]pyridines and Purines as Potent TrkA Inhibitors.
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  Data: <searchLink fieldCode="AU" term="%22Wang+T%22">Wang T</searchLink>; Oncology Innovative Medicines Unit, AstraZeneca R&D Boston , 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.<br /><searchLink fieldCode="AU" term="%22Lamb+ML%22">Lamb ML</searchLink>; Oncology Innovative Medicines Unit, AstraZeneca R&D Boston , 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.<br /><searchLink fieldCode="AU" term="%22Block+MH%22">Block MH</searchLink>; Oncology Innovative Medicines Unit, AstraZeneca R&D Boston , 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.<br /><searchLink fieldCode="AU" term="%22Davies+AM%22">Davies AM</searchLink>; Oncology Innovative Medicines Unit, AstraZeneca R&D Boston , 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.<br /><searchLink fieldCode="AU" term="%22Han+Y%22">Han Y</searchLink>; Array BioPharma Inc. , 3200 Walnut Street, Boulder, Colorado 80301, United States.<br /><searchLink fieldCode="AU" term="%22Hoffmann+E%22">Hoffmann E</searchLink>; Oncology Innovative Medicines Unit, AstraZeneca R&D Boston , 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.<br /><searchLink fieldCode="AU" term="%22Ioannidis+S%22">Ioannidis S</searchLink>; Oncology Innovative Medicines Unit, AstraZeneca R&D Boston , 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.<br /><searchLink fieldCode="AU" term="%22Josey+JA%22">Josey JA</searchLink>; Array BioPharma Inc. , 3200 Walnut Street, Boulder, Colorado 80301, United States.<br /><searchLink fieldCode="AU" term="%22Liu+ZY%22">Liu ZY</searchLink>; Oncology Innovative Medicines Unit, AstraZeneca R&D Boston , 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.<br /><searchLink fieldCode="AU" term="%22Lyne+PD%22">Lyne PD</searchLink>; Oncology Innovative Medicines Unit, AstraZeneca R&D Boston , 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.<br /><searchLink fieldCode="AU" term="%22MacIntyre+T%22">MacIntyre T</searchLink>; Oncology Innovative Medicines Unit, AstraZeneca R&D Boston , 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.<br /><searchLink fieldCode="AU" term="%22Mohr+PJ%22">Mohr PJ</searchLink>; Array BioPharma Inc. , 3200 Walnut Street, Boulder, Colorado 80301, United States.<br /><searchLink fieldCode="AU" term="%22Omer+CA%22">Omer CA</searchLink>; Oncology Innovative Medicines Unit, AstraZeneca R&D Boston , 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.<br /><searchLink fieldCode="AU" term="%22Sjögren+T%22">Sjögren T</searchLink>; Discovery Sciences, Innovative Medicines, AstraZeneca , Pepparedsleden S431 83 Mölndal, Sweden.<br /><searchLink fieldCode="AU" term="%22Thress+K%22">Thress K</searchLink>; Oncology Innovative Medicines Unit, AstraZeneca R&D Boston , 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.<br /><searchLink fieldCode="AU" term="%22Wang+B%22">Wang B</searchLink>; Array BioPharma Inc. , 3200 Walnut Street, Boulder, Colorado 80301, United States.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Oncology Innovative Medicines Unit, AstraZeneca R&D Boston , 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.<br /><searchLink fieldCode="AU" term="%22Yu+D%22">Yu D</searchLink>; Oncology Innovative Medicines Unit, AstraZeneca R&D Boston , 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.<br /><searchLink fieldCode="AU" term="%22Zhang+HJ%22">Zhang HJ</searchLink>; Oncology Innovative Medicines Unit, AstraZeneca R&D Boston , 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
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              Text: 2012 Jul 26
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