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SUCLG2 identified as both a determinator of CSF Aβ1-42 levels and an attenuator of cognitive decline in Alzheimer's disease.

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Title: SUCLG2 identified as both a determinator of CSF Aβ1-42 levels and an attenuator of cognitive decline in Alzheimer's disease.
Authors: Ramirez A; Department of Psychiatry and Psychotherapy, Institute of Human Genetics, alfredo.ramirez@ukb.uni-bonn.de., van der Flier WM; Department of Neurology and Alzheimer Center, Neuroscience Campus Amsterdam, VU University Medical Center, 1081 HZ, Amsterdam, The Netherlands, Department of Epidemiology & Biostatistics, VU University Medical Center, 1007 MB, Amsterdam, The Netherlands., Herold C; German Center for Neurodegenerative Diseases (DZNE), 53175, Bonn, Germany., Ramonet D; Clinical Neuroscience Unit, Department of Neurology., Heilmann S; Institute of Human Genetics, Department of Genomics, Life & Brain Center., Lewczuk P; Department of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen, and Friedrich-Alexander Universität Erlangen-Nürnberg, 91054, Erlangen, Germany., Popp J; Department of Psychiatry and Psychotherapy., Lacour A; German Center for Neurodegenerative Diseases (DZNE), 53175, Bonn, Germany., Drichel D; German Center for Neurodegenerative Diseases (DZNE), 53175, Bonn, Germany., Louwersheimer E; Department of Neurology and Alzheimer Center, Neuroscience Campus Amsterdam, VU University Medical Center, 1081 HZ, Amsterdam, The Netherlands, Department of Epidemiology & Biostatistics, VU University Medical Center, 1007 MB, Amsterdam, The Netherlands., Kummer MP; Clinical Neuroscience Unit, Department of Neurology, German Center for Neurodegenerative Diseases (DZNE), 53175, Bonn, Germany., Cruchaga C; Department of Psychiatry, Hope Center for Neurological Disorders, School of Medicine., Hoffmann P; Institute of Human Genetics, Department of Genomics, Life & Brain Center, Division of Medical Genetics, University Hospital and Department of Biomedicine, University of Basel, CH-4058, Basel, Switzerland., Teunissen C; Department of Neurology and Alzheimer Center, Neuroscience Campus Amsterdam, VU University Medical Center, 1081 HZ, Amsterdam, The Netherlands, Department of Epidemiology & Biostatistics, VU University Medical Center, 1007 MB, Amsterdam, The Netherlands., Holstege H; Department of Neurology and Alzheimer Center, Neuroscience Campus Amsterdam, VU University Medical Center, 1081 HZ, Amsterdam, The Netherlands, Department of Epidemiology & Biostatistics, VU University Medical Center, 1007 MB, Amsterdam, The Netherlands., Kornhuber J; Department of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen, and Friedrich-Alexander Universität Erlangen-Nürnberg, 91054, Erlangen, Germany., Peters O; Department of Psychiatry, Charité, 14050, Berlin, Germany., Naj AC; Center for Clinical Epidemiology & Biostatistics, University of Pennsylvania, PA 19104, Philadelphia, USA., Chouraki V; Department of Neurology, Boston University School of Medicine, MA 02118, Boston, USA, The Framingham Heart Study, MA 01702, Framingham, USA., Bellenguez C; Inserm, U744, Lille 59000, France, Université Lille 2, Lille 59000, France, Institut Pasteur de Lille, Lille 59000, France., Gerrish A; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK., Heun R; Department of Psychiatry and Psychotherapy., Frölich L; Department of Geriatric Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, 68159, Mannheim, Germany., Hüll M; Centre for Geriatric Medicine and Section of Gerontopsychiatry and Neuropsychology, Medical School, University of Freiburg, 79106, Freiburg, Germany., Buscemi L; Department of Fundamental Neurosciences, UNIL, 1005 Lausanne, Switzerland and., Herms S; Institute of Human Genetics, Department of Genomics, Life & Brain Center, Division of Medical Genetics, University Hospital and Department of Biomedicine, University of Basel, CH-4058, Basel, Switzerland., Kölsch H; Department of Psychiatry and Psychotherapy., Scheltens P; Department of Neurology and Alzheimer Center, Neuroscience Campus Amsterdam, VU University Medical Center, 1081 HZ, Amsterdam, The Netherlands, Department of Epidemiology & Biostatistics, VU University Medical Center, 1007 MB, Amsterdam, The Netherlands., Breteler MM; German Center for Neurodegenerative Diseases (DZNE), 53175, Bonn, Germany., Rüther E; Department of Psychiatry and Psychotherapy, University of Göttingen, 37075 Göttingen, Germany., Wiltfang J; Department of Psychiatry and Psychotherapy, University of Göttingen, 37075 Göttingen, Germany., Goate A; Department of Psychiatry, Department of Genetics, Washington University, St. Louis, MO 63110, USA., Jessen F; Department of Psychiatry and Psychotherapy, German Center for Neurodegenerative Diseases (DZNE), 53175, Bonn, Germany., Maier W; Department of Psychiatry and Psychotherapy, German Center for Neurodegenerative Diseases (DZNE), 53175, Bonn, Germany., Heneka MT; Clinical Neuroscience Unit, Department of Neurology, German Center for Neurodegenerative Diseases (DZNE), 53175, Bonn, Germany., Becker T; Institute for Medical Biometry, Informatics, and Epidemiology, University of Bonn, 53127, Bonn, Germany, German Center for Neurodegenerative Diseases (DZNE), 53175, Bonn, Germany., Nöthen MM; Institute of Human Genetics, Department of Genomics, Life & Brain Center.
Corporate Authors: International Genomics of Alzheimer's Project (IGAP), Alzheimer's Disease Neuroimaging Initiative (ADNI)
Source: Human molecular genetics [Hum Mol Genet] 2014 Dec 15; Vol. 23 (24), pp. 6644-58. Date of Electronic Publication: 2014 Jul 15.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: IRL Press at Oxford University Press Country of Publication: England NLM ID: 9208958 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2083 (Electronic) Linking ISSN: 09646906 NLM ISO Abbreviation: Hum Mol Genet Subsets: MEDLINE
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  Data: SUCLG2 identified as both a determinator of CSF Aβ1-42 levels and an attenuator of cognitive decline in Alzheimer's disease.
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  Data: <searchLink fieldCode="AU" term="%22Ramirez+A%22">Ramirez A</searchLink>; Department of Psychiatry and Psychotherapy, Institute of Human Genetics, alfredo.ramirez@ukb.uni-bonn.de.<br /><searchLink fieldCode="AU" term="%22van+der+Flier+WM%22">van der Flier WM</searchLink>; Department of Neurology and Alzheimer Center, Neuroscience Campus Amsterdam, VU University Medical Center, 1081 HZ, Amsterdam, The Netherlands, Department of Epidemiology & Biostatistics, VU University Medical Center, 1007 MB, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Herold+C%22">Herold C</searchLink>; German Center for Neurodegenerative Diseases (DZNE), 53175, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Ramonet+D%22">Ramonet D</searchLink>; Clinical Neuroscience Unit, Department of Neurology.<br /><searchLink fieldCode="AU" term="%22Heilmann+S%22">Heilmann S</searchLink>; Institute of Human Genetics, Department of Genomics, Life & Brain Center.<br /><searchLink fieldCode="AU" term="%22Lewczuk+P%22">Lewczuk P</searchLink>; Department of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen, and Friedrich-Alexander Universität Erlangen-Nürnberg, 91054, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Popp+J%22">Popp J</searchLink>; Department of Psychiatry and Psychotherapy.<br /><searchLink fieldCode="AU" term="%22Lacour+A%22">Lacour A</searchLink>; German Center for Neurodegenerative Diseases (DZNE), 53175, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Drichel+D%22">Drichel D</searchLink>; German Center for Neurodegenerative Diseases (DZNE), 53175, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Louwersheimer+E%22">Louwersheimer E</searchLink>; Department of Neurology and Alzheimer Center, Neuroscience Campus Amsterdam, VU University Medical Center, 1081 HZ, Amsterdam, The Netherlands, Department of Epidemiology & Biostatistics, VU University Medical Center, 1007 MB, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Kummer+MP%22">Kummer MP</searchLink>; Clinical Neuroscience Unit, Department of Neurology, German Center for Neurodegenerative Diseases (DZNE), 53175, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Cruchaga+C%22">Cruchaga C</searchLink>; Department of Psychiatry, Hope Center for Neurological Disorders, School of Medicine.<br /><searchLink fieldCode="AU" term="%22Hoffmann+P%22">Hoffmann P</searchLink>; Institute of Human Genetics, Department of Genomics, Life & Brain Center, Division of Medical Genetics, University Hospital and Department of Biomedicine, University of Basel, CH-4058, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Teunissen+C%22">Teunissen C</searchLink>; Department of Neurology and Alzheimer Center, Neuroscience Campus Amsterdam, VU University Medical Center, 1081 HZ, Amsterdam, The Netherlands, Department of Epidemiology & Biostatistics, VU University Medical Center, 1007 MB, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Holstege+H%22">Holstege H</searchLink>; Department of Neurology and Alzheimer Center, Neuroscience Campus Amsterdam, VU University Medical Center, 1081 HZ, Amsterdam, The Netherlands, Department of Epidemiology & Biostatistics, VU University Medical Center, 1007 MB, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Kornhuber+J%22">Kornhuber J</searchLink>; Department of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen, and Friedrich-Alexander Universität Erlangen-Nürnberg, 91054, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Peters+O%22">Peters O</searchLink>; Department of Psychiatry, Charité, 14050, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Naj+AC%22">Naj AC</searchLink>; Center for Clinical Epidemiology & Biostatistics, University of Pennsylvania, PA 19104, Philadelphia, USA.<br /><searchLink fieldCode="AU" term="%22Chouraki+V%22">Chouraki V</searchLink>; Department of Neurology, Boston University School of Medicine, MA 02118, Boston, USA, The Framingham Heart Study, MA 01702, Framingham, USA.<br /><searchLink fieldCode="AU" term="%22Bellenguez+C%22">Bellenguez C</searchLink>; 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Institute for Medical Biometry, Informatics, and Epidemiology, University of Bonn, 53127, Bonn, Germany, German Center for Neurodegenerative Diseases (DZNE), 53175, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Nöthen+MM%22">Nöthen MM</searchLink>; Institute of Human Genetics, Department of Genomics, Life & Brain Center.
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