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Structural basis for AMPK activation: natural and synthetic ligands regulate kinase activity from opposite poles by different molecular mechanisms.

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Title: Structural basis for AMPK activation: natural and synthetic ligands regulate kinase activity from opposite poles by different molecular mechanisms.
Authors: Calabrese MF; Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA., Rajamohan F; Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA., Harris MS; Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA., Caspers NL; Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA., Magyar R; Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA., Withka JM; Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA., Wang H; Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA., Borzilleri KA; Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA., Sahasrabudhe PV; Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA., Hoth LR; Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA., Geoghegan KF; Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA., Han S; Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA., Brown J; Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA., Subashi TA; Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA., Reyes AR; Worldwide Research and Development, Pfizer Inc., 610 Main Street, Cambridge, MA 02139, USA., Frisbie RK; Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA., Ward J; Worldwide Research and Development, Pfizer Inc., 610 Main Street, Cambridge, MA 02139, USA., Miller RA; Worldwide Research and Development, Pfizer Inc., 610 Main Street, Cambridge, MA 02139, USA., Landro JA; Worldwide Research and Development, Pfizer Inc., 610 Main Street, Cambridge, MA 02139, USA., Londregan AT; Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA., Carpino PA; Worldwide Research and Development, Pfizer Inc., 610 Main Street, Cambridge, MA 02139, USA., Cabral S; Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA., Smith AC; Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA., Conn EL; Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA., Cameron KO; Worldwide Research and Development, Pfizer Inc., 610 Main Street, Cambridge, MA 02139, USA., Qiu X; Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA., Kurumbail RG; Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA. Electronic address: ravi.g.kurumbail@pfizer.com.
Source: Structure (London, England : 1993) [Structure] 2014 Aug 05; Vol. 22 (8), pp. 1161-1172. Date of Electronic Publication: 2014 Jul 24.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101087697 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-4186 (Electronic) Linking ISSN: 09692126 NLM ISO Abbreviation: Structure Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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