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Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study.

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Title: Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study.
Authors: Naj AC; Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia., Jun G; Genetics Program, Department of Medicine, Boston University, Boston, Massachusetts4Department of Biostatistics, Boston University, Boston, Massachusetts5Department of Ophthalmology, Boston University, Boston, Massachusetts., Reitz C; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, New York7Gertrude H. Sergievsky Center, Columbia University, New York, New York8Department of Neurology, Columbia University, New York, New., Kunkle BW; John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida., Perry W; John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida., Park YS; The Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida., Beecham GW; John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida9The Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida., Rajbhandary RA; John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida., Hamilton-Nelson KL; John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida., Wang LS; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia., Kauwe JS; Department of Biology, Brigham Young University, Provo, Utah., Huentelman MJ; Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona., Myers AJ; Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, Florida., Bird TD; Department of Neurology, University of Washington, Seattle15Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington., Boeve BF; Department of Neurology, Mayo Clinic, Rochester, Minnesota., Baldwin CT; Genetics Program, Department of Medicine, Boston University, Boston, Massachusetts., Jarvik GP; Department of Genome Sciences, University of Washington, Seattle18Division of Medical Genetics, Department of Medicine, University of Washington, Seattle., Crane PK; Department of Medicine, University of Washington, Seattle., Rogaeva E; Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada., Barmada MM; Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania., Demirci FY; Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania., Cruchaga C; Department of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration, School of Medicine, Washington University in St Louis, St Louis, Missouri., Kramer PL; Department of Neurology, Oregon Health & Science University, Portland24Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland., Ertekin-Taner N; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida26Department of Neurology, Mayo Clinic, Jacksonville, Florida., Hardy J; Institute of Neurology, University College London, London, England., Graff-Radford NR; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida26Department of Neurology, Mayo Clinic, Jacksonville, Florida., Green RC; Division of Genetics, Department of Medicine, and Partners Center for Personalized Genetic Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts., Larson EB; Department of Medicine, University of Washington, Seattle29Group Health Research Institute, Group Health Cooperative, Seattle, Washington., St George-Hyslop PH; Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada30Cambridge Institute for Medical Research, Department of Clinical Neurosciences, University of Cambridge, Cambridge, England., Buxbaum JD; Department of Neuroscience, Mount Sinai School of Medicine, New York, New York32Department of Psychiatry, Mount Sinai School of Medicine, New York, New York33Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York., Evans DA; Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois., Schneider JA; Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois36Neuropathology, Department of Pathology, Rush University Medical Center, Chicago, Illinois., Lunetta KL; Department of Biostatistics, Boston University, Boston, Massachusetts., Kamboh MI; Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania37Alheimer Disease Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania., Saykin AJ; Department of Medical and Molecular Genetics, Indiana University, Indianapolis39Department of Radiology and Imaging Sciences, Indiana University, Indianapolis., Reiman EM; Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona40Arizona Alzheimer's Consortium, Phoenix41Department of Psychiatry, University of Arizona, Phoenix42Banner Alzheimer's Institute, Phoenix, Arizona., De Jager PL; Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology and Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts44Program in Medical and Population Genetics, Broad Ins., Bennett DA; Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois45Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois., Morris JC; Department of Pathology and Immunology, Washington University in St Louis, St Louis, Missouri47Department of Neurology, Washington University in St Louis, St Louis, Missouri., Montine TJ; Department of Pathology, University of Washington, Seattle., Goate AM; Department of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration, School of Medicine, Washington University in St Louis, St Louis, Missouri., Blacker D; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts50Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston., Tsuang DW; Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington51Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle., Hakonarson H; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Kukull WA; Department of Epidemiology, University of Washington, Seattle., Foroud TM; Department of Medical and Molecular Genetics, Indiana University, Indianapolis., Martin ER; John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida9The Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida., Haines JL; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee55Vanderbilit Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee., Mayeux RP; Taub Institute on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York57Gertrude H. Sergievsky Center, Columbia University, New York, New York58Department of Neurology, Columbia University, New York, New York., Farrer LA; Genetics Program, Department of Medicine, Boston University, Boston, Massachusetts4Department of Biostatistics, Boston University, Boston, Massachusetts5Department of Ophthalmology, Boston University, Boston, Massachusetts59Department of Epidemiology, Bos., Schellenberg GD; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia., Pericak-Vance MA; John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida9The Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida., Albert MS; Department of Neurology, Johns Hopkins University, Baltimore, Maryland., Albin RL; Department of Neurology, University of Michigan, Ann Arbor63Geriatric Research, Education and Clinical Center (GRECC), VA Ann Arbor Healthcare System (VAAAHS), Ann Arbor, Michigan64Michigan Alzheimer Disease Center, Ann Arbor., Apostolova LG; Department of Neurology, University of California Los Angeles, Los Angeles., Arnold SE; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia., Barber R; Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth., Barnes LL; Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois68Department of Behavioral Sciences, Rush University Medical Center, Chicago, Illinois., Beach TG; Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Phoenix, Arizona., Becker JT; Departments of Psychiatry, Neurology, and Psychology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Beekly D; National Alzheimer's Coordinating Center, University of Washington, Seattle., Bigio EH; Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois73Cognitive Neurology and Alzheimer's Disease Center, Northwestern University, Chicago, Illinois., Bowen JD; Swedish Medical Center, Seattle, Washington., Boxer A; Department of Neurology, University of California San Francisco, San Francisco., Burke JR; Department of Medicine, Duke University, Durham, North Carolina., Cairns NJ; Department of Pathology and Immunology, Washington University in St Louis, St Louis, Missouri., Cantwell LB; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia., Cao C; USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa., Carlson CS; Fred Hutchinson Cancer Research Center, Seattle, Washington., Carney RM; Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, Florida., Carrasquillo MM; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida., Carroll SL; Department of Pathology, University of Alabama at Birmingham, Birmingham., Chui HC; Department of Neurology, University of Southern California, Los Angeles., Clark DG; Department of Neurology, University of Alabama at Birmingham, Birmingham., Corneveaux J; Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona., Cribbs DH; Department of Neurology, University of California Irvine, Irvine., Crocco EA; Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, Florida., DeCarli C; Department of Neurology, University of California Davis, Sacramento., DeKosky ST; University of Virginia School of Medicine, Charlottesville., Dick M; Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine., Dickson DW; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida., Duara R; Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, Florida., Faber KM; Department of Medical and Molecular Genetics, Indiana University, Indianapolis., Fallon KB; Department of Pathology, University of Alabama at Birmingham, Birmingham., Farlow MR; Department of Neurology, Indiana University, Indianapolis., Ferris S; Department of Psychiatry, New York University, New York., Frosch MP; C.S. Kubik Laboratory for Neuropathology, Massachusetts General Hospital, Charlestown., Galasko DR; Department of Neurosciences, University of California San Diego, La Jolla., Ganguli M; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania., Gearing M; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia93Emory Alzheimer's Disease Center, Emory University, Atlanta, Georgia., Geschwind DH; Neurogenetics Program, University of California Los Angeles, Los Angeles., Ghetti B; Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis., Gilbert JR; John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida9The Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida., Glass JD; Department of Neurology, Emory University, Atlanta, Georgia., Growdon JH; Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston., Hamilton RL; Department of Pathology (Neuropathology), University of Pittsburgh, Pittsburgh, Pennsylvania., Harrell LE; Department of Neurology, University of Alabama at Birmingham, Birmingham., Head E; Sanders-Brown Center on Aging, Department of Molecular and Biomedical Pharmacology, University of Kentucky, Lexington., Honig LS; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, New York., Hulette CM; Department of Pathology, Duke University, Durham, North Carolina., Hyman BT; Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston., Jicha GA; Sanders-Brown Center on Aging, Department Neurology, University of Kentucky, Lexington., Jin LW; Department of Pathology and Laboratory Medicine, University of California Davis, Sacramento., Karydas A; Department of Neurology, University of California San Francisco, San Francisco., Kaye JA; Department of Neurology, Oregon Health & Science University, Portland103Department of Neurology, Portland Veterans Affairs Medical Center, Portland, Oregon., Kim R; Department of Pathology and Laboratory Medicine, University of California Irvine, Irvine., Koo EH; Department of Neurosciences, University of California San Diego, La Jolla., Kowall NW; Department of Neurology, Boston University, Boston, Massachusetts105Department of Pathology, Boston University, Boston, Massachusetts., Kramer JH; Department of Neuropsychology, University of California San Francisco, San Francisco., LaFerla FM; Department of Neurobiology and Behavior, University of California Irvine, Irvine., Lah JJ; Department of Neurology, Emory University, Atlanta, Georgia., Leverenz JB; Department of Pathology, University of Washington, Seattle., Levey AI; Department of Neurology, Emory University, Atlanta, Georgia., Li G; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle., Lieberman AP; Department of Pathology, University of Michigan, Ann Arbor., Lin CF; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia., Lopez OL; Alheimer Disease Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania., Lyketsos CG; Department of Psychiatry, Johns Hopkins University, Baltimore, Maryland., Mack WJ; Department of Preventive Medicine, University of Southern California, Los Angeles., Martiniuk F; Department of Medicine - Pulmonary, New York University, New York., Mash DC; Department of Neurology, University of Miami, Miami, Florida., Masliah E; Department of Neurosciences, University of California San Diego, La Jolla113Department of Pathology, University of California San Diego, La Jolla., McCormick WC; Department of Medicine, University of Washington, Seattle., McCurry SM; School of Nursing Northwest Research Group on Aging, University of Washington, Seattle., McDavid AN; Fred Hutchinson Cancer Research Center, Seattle, Washington., McKee AC; Department of Neurology, Boston University, Boston, Massachusetts105Department of Pathology, Boston University, Boston, Massachusetts., Mesulam M; Cognitive Neurology and Alzheimer's Disease Center, Northwestern University, Chicago, Illinois115Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois., Miller BL; Department of Neurology, University of California San Francisco, San Francisco., Miller CA; Department of Pathology, University of Southern California, Los Angeles., Miller JW; Department of Pathology and Laboratory Medicine, University of California Davis, Sacramento., Murrell JR; Department of Medical and Molecular Genetics, Indiana University, Indianapolis95Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis., Olichney JM; Department of Neurology, University of California Davis, Sacramento., Pankratz VS; Department of Biostatistics, Mayo Clinic, Rochester, Minnesota., Parisi JE; Department of Anatomic Pathology, Mayo Clinic, Rochester, Minnesota119Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota., Paulson HL; Department of Neurology, University of Michigan, Ann Arbor., Peskind E; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle., Petersen RC; Department of Neurology, Mayo Clinic, Rochester, Minnesota., Pierce A; Department of Neurology, University of California Irvine, Irvine., Poon WW; Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine., Potter H; USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa., Quinn JF; Department of Neurology, Oregon Health & Science University, Portland., Raj A; USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa., Raskind M; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle., Reisberg B; Department of Psychiatry, New York University, New York120Alzheimer's Disease Center, New York University, New York., Ringman JM; Department of Neurology, University of California Los Angeles, Los Angeles., Roberson ED; Department of Neurology, University of Alabama at Birmingham, Birmingham., Rosen HJ; Department of Neurology, University of California San Francisco, San Francisco., Rosenberg RN; Department of Neurology, University of Texas Southwestern, Dallas., Sano M; Department of Psychiatry, Mount Sinai School of Medicine, New York, New York., Schneider LS; Department of Neurology, University of Southern California, Los Angeles122Department of Psychiatry, University of Southern California, Los Angeles., Seeley WW; Department of Neurology, University of California San Francisco, San Francisco., Smith AG; USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa., Sonnen JA; Department of Pathology, University of Washington, Seattle., Spina S; Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis., Stern RA; Department of Neurology, Boston University, Boston, Massachusetts., Tanzi RE; Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston., Thornton-Wells TA; Vanderbilit Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee., Trojanowski JQ; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia., Troncoso JC; Department of Pathology, Johns Hopkins University, Baltimore, Maryland., Valladares O; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia., Van Deerlin VM; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia., Van Eldik LJ; Sanders-Brown Center on Aging, Department of Anatomy and Neurobiology, University of Kentucky, Lexington., Vardarajan BN; Department of Neurology, Columbia University, New York, New York., Vinters HV; Department of Neurology, University of California Los Angeles, Los Angeles125Department of Pathology & Laboratory Medicine, University of California Los Angeles, Los Angeles., Vonsattel JP; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Pathology, Columbia University, New York, New York., Weintraub S; Cognitive Neurology and Alzheimer's Disease Center, Northwestern University, Chicago, Illinois127Department of Psychiatry, Northwestern University Feinberg School of Medicine, Chicago, Illinois., Welsh-Bohmer KA; Department of Medicine, Duke University, Durham, North Carolina128Department of Psychiatry & Behavioral Sciences, Duke University, Durham, North Carolina., Williamson J; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, New York., Wishnek S; John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida., Woltjer RL; Department of Pathology, Oregon Health & Science University, Portland., Wright CB; Evelyn F. McKnight Brain Institute, Department of Neurology, Miller School of Medicine, University of Miami, Miami, Florida., Younkin SG; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida., Yu CE; Department of Medicine, University of Washington, Seattle., Yu L; Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois.
Corporate Authors: Alzheimer Disease Genetics Consortium
Source: JAMA neurology [JAMA Neurol] 2014 Nov; Vol. 71 (11), pp. 1394-404.
Publication Type: Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 101589536 Publication Model: Print Cited Medium: Internet ISSN: 2168-6157 (Electronic) Linking ISSN: 21686149 NLM ISO Abbreviation: JAMA Neurol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Label: Title
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  Data: Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study.
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  Label: Authors
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  Data: <searchLink fieldCode="AU" term="%22Naj+AC%22">Naj AC</searchLink>; Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia.<br /><searchLink fieldCode="AU" term="%22Jun+G%22">Jun G</searchLink>; Genetics Program, Department of Medicine, Boston University, Boston, Massachusetts4Department of Biostatistics, Boston University, Boston, Massachusetts5Department of Ophthalmology, Boston University, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Reitz+C%22">Reitz C</searchLink>; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, New York7Gertrude H. Sergievsky Center, Columbia University, New York, New York8Department of Neurology, Columbia University, New York, New.<br /><searchLink fieldCode="AU" term="%22Kunkle+BW%22">Kunkle BW</searchLink>; John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida.<br /><searchLink fieldCode="AU" term="%22Perry+W%22">Perry W</searchLink>; John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida.<br /><searchLink fieldCode="AU" term="%22Park+YS%22">Park YS</searchLink>; The Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida.<br /><searchLink fieldCode="AU" term="%22Beecham+GW%22">Beecham GW</searchLink>; John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida9The Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida.<br /><searchLink fieldCode="AU" term="%22Rajbhandary+RA%22">Rajbhandary RA</searchLink>; John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida.<br /><searchLink fieldCode="AU" term="%22Hamilton-Nelson+KL%22">Hamilton-Nelson KL</searchLink>; John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida.<br /><searchLink fieldCode="AU" term="%22Wang+LS%22">Wang LS</searchLink>; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia.<br /><searchLink fieldCode="AU" term="%22Kauwe+JS%22">Kauwe JS</searchLink>; Department of Biology, Brigham Young University, Provo, Utah.<br /><searchLink fieldCode="AU" term="%22Huentelman+MJ%22">Huentelman MJ</searchLink>; Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona.<br /><searchLink fieldCode="AU" term="%22Myers+AJ%22">Myers AJ</searchLink>; Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, Florida.<br /><searchLink fieldCode="AU" term="%22Bird+TD%22">Bird TD</searchLink>; Department of Neurology, University of Washington, Seattle15Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington.<br /><searchLink fieldCode="AU" term="%22Boeve+BF%22">Boeve BF</searchLink>; Department of Neurology, Mayo Clinic, Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Baldwin+CT%22">Baldwin CT</searchLink>; Genetics Program, Department of Medicine, Boston University, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Jarvik+GP%22">Jarvik GP</searchLink>; Department of Genome Sciences, University of Washington, Seattle18Division of Medical Genetics, Department of Medicine, University of Washington, Seattle.<br /><searchLink fieldCode="AU" term="%22Crane+PK%22">Crane PK</searchLink>; Department of Medicine, University of Washington, Seattle.<br /><searchLink fieldCode="AU" term="%22Rogaeva+E%22">Rogaeva E</searchLink>; Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Barmada+MM%22">Barmada MM</searchLink>; Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Demirci+FY%22">Demirci FY</searchLink>; Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Cruchaga+C%22">Cruchaga C</searchLink>; Department of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration, School of Medicine, Washington University in St Louis, St Louis, Missouri.<br /><searchLink fieldCode="AU" term="%22Kramer+PL%22">Kramer PL</searchLink>; Department of Neurology, Oregon Health & Science University, Portland24Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland.<br /><searchLink fieldCode="AU" term="%22Ertekin-Taner+N%22">Ertekin-Taner N</searchLink>; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida26Department of Neurology, Mayo Clinic, Jacksonville, Florida.<br /><searchLink fieldCode="AU" term="%22Hardy+J%22">Hardy J</searchLink>; Institute of Neurology, University College London, London, England.<br /><searchLink fieldCode="AU" term="%22Graff-Radford+NR%22">Graff-Radford NR</searchLink>; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida26Department of Neurology, Mayo Clinic, Jacksonville, Florida.<br /><searchLink fieldCode="AU" term="%22Green+RC%22">Green RC</searchLink>; Division of Genetics, Department of Medicine, and Partners Center for Personalized Genetic Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Larson+EB%22">Larson EB</searchLink>; Department of Medicine, University of Washington, Seattle29Group Health Research Institute, Group Health Cooperative, Seattle, Washington.<br /><searchLink fieldCode="AU" term="%22St+George-Hyslop+PH%22">St George-Hyslop PH</searchLink>; Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada30Cambridge Institute for Medical Research, Department of Clinical Neurosciences, University of Cambridge, Cambridge, England.<br /><searchLink fieldCode="AU" term="%22Buxbaum+JD%22">Buxbaum JD</searchLink>; Department of Neuroscience, Mount Sinai School of Medicine, New York, New York32Department of Psychiatry, Mount Sinai School of Medicine, New York, New York33Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York.<br /><searchLink fieldCode="AU" term="%22Evans+DA%22">Evans DA</searchLink>; Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois.<br /><searchLink fieldCode="AU" term="%22Schneider+JA%22">Schneider JA</searchLink>; Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois36Neuropathology, Department of Pathology, Rush University Medical Center, Chicago, Illinois.<br /><searchLink fieldCode="AU" term="%22Lunetta+KL%22">Lunetta KL</searchLink>; Department of Biostatistics, Boston University, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Kamboh+MI%22">Kamboh MI</searchLink>; Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania37Alheimer Disease Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Saykin+AJ%22">Saykin AJ</searchLink>; Department of Medical and Molecular Genetics, Indiana University, Indianapolis39Department of Radiology and Imaging Sciences, Indiana University, Indianapolis.<br /><searchLink fieldCode="AU" term="%22Reiman+EM%22">Reiman EM</searchLink>; Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona40Arizona Alzheimer's Consortium, Phoenix41Department of Psychiatry, University of Arizona, Phoenix42Banner Alzheimer's Institute, Phoenix, Arizona.<br /><searchLink fieldCode="AU" term="%22De+Jager+PL%22">De Jager PL</searchLink>; Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology and Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts44Program in Medical and Population Genetics, Broad Ins.<br /><searchLink fieldCode="AU" term="%22Bennett+DA%22">Bennett DA</searchLink>; Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois45Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois.<br /><searchLink fieldCode="AU" term="%22Morris+JC%22">Morris JC</searchLink>; Department of Pathology and Immunology, Washington University in St Louis, St Louis, Missouri47Department of Neurology, Washington University in St Louis, St Louis, Missouri.<br /><searchLink fieldCode="AU" term="%22Montine+TJ%22">Montine TJ</searchLink>; Department of Pathology, University of Washington, Seattle.<br /><searchLink fieldCode="AU" term="%22Goate+AM%22">Goate AM</searchLink>; Department of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration, School of Medicine, Washington University in St Louis, St Louis, Missouri.<br /><searchLink fieldCode="AU" term="%22Blacker+D%22">Blacker D</searchLink>; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts50Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston.<br /><searchLink fieldCode="AU" term="%22Tsuang+DW%22">Tsuang DW</searchLink>; Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington51Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle.<br /><searchLink fieldCode="AU" term="%22Hakonarson+H%22">Hakonarson H</searchLink>; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Kukull+WA%22">Kukull WA</searchLink>; Department of Epidemiology, University of Washington, Seattle.<br /><searchLink fieldCode="AU" term="%22Foroud+TM%22">Foroud TM</searchLink>; Department of Medical and Molecular Genetics, Indiana University, Indianapolis.<br /><searchLink fieldCode="AU" term="%22Martin+ER%22">Martin ER</searchLink>; John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida9The Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida.<br /><searchLink fieldCode="AU" term="%22Haines+JL%22">Haines JL</searchLink>; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee55Vanderbilit Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Mayeux+RP%22">Mayeux RP</searchLink>; Taub Institute on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York57Gertrude H. Sergievsky Center, Columbia University, New York, New York58Department of Neurology, Columbia University, New York, New York.<br /><searchLink fieldCode="AU" term="%22Farrer+LA%22">Farrer LA</searchLink>; Genetics Program, Department of Medicine, Boston University, Boston, Massachusetts4Department of Biostatistics, Boston University, Boston, Massachusetts5Department of Ophthalmology, Boston University, Boston, Massachusetts59Department of Epidemiology, Bos.<br /><searchLink fieldCode="AU" term="%22Schellenberg+GD%22">Schellenberg GD</searchLink>; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia.<br /><searchLink fieldCode="AU" term="%22Pericak-Vance+MA%22">Pericak-Vance MA</searchLink>; John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida9The Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida.<br /><searchLink fieldCode="AU" term="%22Albert+MS%22">Albert MS</searchLink>; Department of Neurology, Johns Hopkins University, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Albin+RL%22">Albin RL</searchLink>; Department of Neurology, University of Michigan, Ann Arbor63Geriatric Research, Education and Clinical Center (GRECC), VA Ann Arbor Healthcare System (VAAAHS), Ann Arbor, Michigan64Michigan Alzheimer Disease Center, Ann Arbor.<br /><searchLink fieldCode="AU" term="%22Apostolova+LG%22">Apostolova LG</searchLink>; Department of Neurology, University of California Los Angeles, Los Angeles.<br /><searchLink fieldCode="AU" term="%22Arnold+SE%22">Arnold SE</searchLink>; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia.<br /><searchLink fieldCode="AU" term="%22Barber+R%22">Barber R</searchLink>; Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth.<br /><searchLink fieldCode="AU" term="%22Barnes+LL%22">Barnes LL</searchLink>; 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Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, Florida.<br /><searchLink fieldCode="AU" term="%22DeCarli+C%22">DeCarli C</searchLink>; Department of Neurology, University of California Davis, Sacramento.<br /><searchLink fieldCode="AU" term="%22DeKosky+ST%22">DeKosky ST</searchLink>; University of Virginia School of Medicine, Charlottesville.<br /><searchLink fieldCode="AU" term="%22Dick+M%22">Dick M</searchLink>; Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine.<br /><searchLink fieldCode="AU" term="%22Dickson+DW%22">Dickson DW</searchLink>; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida.<br /><searchLink fieldCode="AU" term="%22Duara+R%22">Duara R</searchLink>; Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, Florida.<br /><searchLink fieldCode="AU" term="%22Faber+KM%22">Faber KM</searchLink>; Department of Medical and Molecular Genetics, Indiana University, Indianapolis.<br /><searchLink fieldCode="AU" term="%22Fallon+KB%22">Fallon KB</searchLink>; Department of Pathology, University of Alabama at Birmingham, Birmingham.<br /><searchLink fieldCode="AU" term="%22Farlow+MR%22">Farlow MR</searchLink>; Department of Neurology, Indiana University, Indianapolis.<br /><searchLink fieldCode="AU" term="%22Ferris+S%22">Ferris S</searchLink>; Department of Psychiatry, New York University, New York.<br /><searchLink fieldCode="AU" term="%22Frosch+MP%22">Frosch MP</searchLink>; C.S. Kubik Laboratory for Neuropathology, Massachusetts General Hospital, Charlestown.<br /><searchLink fieldCode="AU" term="%22Galasko+DR%22">Galasko DR</searchLink>; Department of Neurosciences, University of California San Diego, La Jolla.<br /><searchLink fieldCode="AU" term="%22Ganguli+M%22">Ganguli M</searchLink>; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Gearing+M%22">Gearing M</searchLink>; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia93Emory Alzheimer's Disease Center, Emory University, Atlanta, Georgia.<br /><searchLink fieldCode="AU" term="%22Geschwind+DH%22">Geschwind DH</searchLink>; Neurogenetics Program, University of California Los Angeles, Los Angeles.<br /><searchLink fieldCode="AU" term="%22Ghetti+B%22">Ghetti B</searchLink>; Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis.<br /><searchLink fieldCode="AU" term="%22Gilbert+JR%22">Gilbert JR</searchLink>; John P. 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Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida.<br /><searchLink fieldCode="AU" term="%22Glass+JD%22">Glass JD</searchLink>; Department of Neurology, Emory University, Atlanta, Georgia.<br /><searchLink fieldCode="AU" term="%22Growdon+JH%22">Growdon JH</searchLink>; Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston.<br /><searchLink fieldCode="AU" term="%22Hamilton+RL%22">Hamilton RL</searchLink>; Department of Pathology (Neuropathology), University of Pittsburgh, Pittsburgh, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Harrell+LE%22">Harrell LE</searchLink>; Department of Neurology, University of Alabama at Birmingham, Birmingham.<br /><searchLink fieldCode="AU" term="%22Head+E%22">Head E</searchLink>; Sanders-Brown Center on Aging, Department of Molecular and Biomedical Pharmacology, University of Kentucky, Lexington.<br /><searchLink fieldCode="AU" term="%22Honig+LS%22">Honig LS</searchLink>; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, New York.<br /><searchLink fieldCode="AU" term="%22Hulette+CM%22">Hulette CM</searchLink>; Department of Pathology, Duke University, Durham, North Carolina.<br /><searchLink fieldCode="AU" term="%22Hyman+BT%22">Hyman BT</searchLink>; Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston.<br /><searchLink fieldCode="AU" term="%22Jicha+GA%22">Jicha GA</searchLink>; Sanders-Brown Center on Aging, Department Neurology, University of Kentucky, Lexington.<br /><searchLink fieldCode="AU" term="%22Jin+LW%22">Jin LW</searchLink>; Department of Pathology and Laboratory Medicine, University of California Davis, Sacramento.<br /><searchLink fieldCode="AU" term="%22Karydas+A%22">Karydas A</searchLink>; Department of Neurology, University of California San Francisco, San Francisco.<br /><searchLink fieldCode="AU" term="%22Kaye+JA%22">Kaye JA</searchLink>; Department of Neurology, Oregon Health & Science University, Portland103Department of Neurology, Portland Veterans Affairs Medical Center, Portland, Oregon.<br /><searchLink fieldCode="AU" term="%22Kim+R%22">Kim R</searchLink>; 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Department of Neurology, University of California San Francisco, San Francisco.<br /><searchLink fieldCode="AU" term="%22Smith+AG%22">Smith AG</searchLink>; USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa.<br /><searchLink fieldCode="AU" term="%22Sonnen+JA%22">Sonnen JA</searchLink>; Department of Pathology, University of Washington, Seattle.<br /><searchLink fieldCode="AU" term="%22Spina+S%22">Spina S</searchLink>; Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis.<br /><searchLink fieldCode="AU" term="%22Stern+RA%22">Stern RA</searchLink>; Department of Neurology, Boston University, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Tanzi+RE%22">Tanzi RE</searchLink>; Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston.<br /><searchLink fieldCode="AU" term="%22Thornton-Wells+TA%22">Thornton-Wells TA</searchLink>; Vanderbilit Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Trojanowski+JQ%22">Trojanowski JQ</searchLink>; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia.<br /><searchLink fieldCode="AU" term="%22Troncoso+JC%22">Troncoso JC</searchLink>; Department of Pathology, Johns Hopkins University, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Valladares+O%22">Valladares O</searchLink>; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia.<br /><searchLink fieldCode="AU" term="%22Van+Deerlin+VM%22">Van Deerlin VM</searchLink>; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia.<br /><searchLink fieldCode="AU" term="%22Van+Eldik+LJ%22">Van Eldik LJ</searchLink>; Sanders-Brown Center on Aging, Department of Anatomy and Neurobiology, University of Kentucky, Lexington.<br /><searchLink fieldCode="AU" term="%22Vardarajan+BN%22">Vardarajan BN</searchLink>; Department of Neurology, Columbia University, New York, New York.<br /><searchLink fieldCode="AU" term="%22Vinters+HV%22">Vinters HV</searchLink>; 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John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida.<br /><searchLink fieldCode="AU" term="%22Woltjer+RL%22">Woltjer RL</searchLink>; Department of Pathology, Oregon Health & Science University, Portland.<br /><searchLink fieldCode="AU" term="%22Wright+CB%22">Wright CB</searchLink>; Evelyn F. McKnight Brain Institute, Department of Neurology, Miller School of Medicine, University of Miami, Miami, Florida.<br /><searchLink fieldCode="AU" term="%22Younkin+SG%22">Younkin SG</searchLink>; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida.<br /><searchLink fieldCode="AU" term="%22Yu+CE%22">Yu CE</searchLink>; Department of Medicine, University of Washington, Seattle.<br /><searchLink fieldCode="AU" term="%22Yu+L%22">Yu L</searchLink>; Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois.
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  Data: <searchLink fieldCode="JN" term="%22101589536%22">JAMA neurology</searchLink> [JAMA Neurol] 2014 Nov; Vol. 71 (11), pp. 1394-404.
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        Value: 10.1001/jamaneurol.2014.1491
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      – TitleFull: Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study.
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    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 11
              Text: 2014 Nov
              Type: published
              Y: 2014
          Identifiers:
            – Type: issn-electronic
              Value: 2168-6157
          Numbering:
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              Value: 71
            – Type: issue
              Value: 11
          Titles:
            – TitleFull: JAMA neurology
              Type: main
ResultId 1