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Fragment-based screening in tandem with phenotypic screening provides novel antiparasitic hits.

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Title: Fragment-based screening in tandem with phenotypic screening provides novel antiparasitic hits.
Authors: Blaazer AR; Division of Medicinal Chemistry, Faculty of Sciences, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), VU University Amsterdam, Amsterdam, The Netherlands., Orrling KM; Division of Medicinal Chemistry, Faculty of Sciences, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), VU University Amsterdam, Amsterdam, The Netherlands TI Pharma, Leiden, The Netherlands., Shanmugham A; IOTA Pharmaceuticals, Cambridge, UK., Jansen C; Division of Medicinal Chemistry, Faculty of Sciences, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), VU University Amsterdam, Amsterdam, The Netherlands University of Dundee, Dundee, UK., Maes L; Laboratory for Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Belgium., Edink E; Division of Medicinal Chemistry, Faculty of Sciences, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), VU University Amsterdam, Amsterdam, The Netherlands., Sterk GJ; Division of Medicinal Chemistry, Faculty of Sciences, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), VU University Amsterdam, Amsterdam, The Netherlands., Siderius M; Division of Medicinal Chemistry, Faculty of Sciences, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), VU University Amsterdam, Amsterdam, The Netherlands., England P; IOTA Pharmaceuticals, Cambridge, UK., Bailey D; IOTA Pharmaceuticals, Cambridge, UK., de Esch IJ; Division of Medicinal Chemistry, Faculty of Sciences, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), VU University Amsterdam, Amsterdam, The Netherlands., Leurs R; Division of Medicinal Chemistry, Faculty of Sciences, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), VU University Amsterdam, Amsterdam, The Netherlands r.leurs@vu.nl.
Source: Journal of biomolecular screening [J Biomol Screen] 2015 Jan; Vol. 20 (1), pp. 131-40. Date of Electronic Publication: 2014 Sep 17.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Sage Publications Country of Publication: United States NLM ID: 9612112 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-454X (Electronic) Linking ISSN: 10870571 NLM ISO Abbreviation: J Biomol Screen Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Fragment-based screening in tandem with phenotypic screening provides novel antiparasitic hits.
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  Data: <searchLink fieldCode="AU" term="%22Blaazer+AR%22">Blaazer AR</searchLink>; Division of Medicinal Chemistry, Faculty of Sciences, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), VU University Amsterdam, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Orrling+KM%22">Orrling KM</searchLink>; Division of Medicinal Chemistry, Faculty of Sciences, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), VU University Amsterdam, Amsterdam, The Netherlands TI Pharma, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Shanmugham+A%22">Shanmugham A</searchLink>; IOTA Pharmaceuticals, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Jansen+C%22">Jansen C</searchLink>; Division of Medicinal Chemistry, Faculty of Sciences, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), VU University Amsterdam, Amsterdam, The Netherlands University of Dundee, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Maes+L%22">Maes L</searchLink>; Laboratory for Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Belgium.<br /><searchLink fieldCode="AU" term="%22Edink+E%22">Edink E</searchLink>; Division of Medicinal Chemistry, Faculty of Sciences, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), VU University Amsterdam, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Sterk+GJ%22">Sterk GJ</searchLink>; Division of Medicinal Chemistry, Faculty of Sciences, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), VU University Amsterdam, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Siderius+M%22">Siderius M</searchLink>; Division of Medicinal Chemistry, Faculty of Sciences, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), VU University Amsterdam, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22England+P%22">England P</searchLink>; IOTA Pharmaceuticals, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Bailey+D%22">Bailey D</searchLink>; IOTA Pharmaceuticals, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22de+Esch+IJ%22">de Esch IJ</searchLink>; Division of Medicinal Chemistry, Faculty of Sciences, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), VU University Amsterdam, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Leurs+R%22">Leurs R</searchLink>; Division of Medicinal Chemistry, Faculty of Sciences, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), VU University Amsterdam, Amsterdam, The Netherlands r.leurs@vu.nl.
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  Data: <searchLink fieldCode="JN" term="%229612112%22">Journal of biomolecular screening</searchLink> [J Biomol Screen] 2015 Jan; Vol. 20 (1), pp. 131-40. <i>Date of Electronic Publication: </i>2014 Sep 17.
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              Text: 2015 Jan
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