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Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands.

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Title: Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands.
Authors: Weinreb I; Department of Pathology, University Health Network, Toronto, Ontario, Canada., Piscuoglio S; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Martelotto LG; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Waggott D; 1] Informatics and Bio-Computing Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada. [2] Ontario Cancer Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Onatrio, Canada. [3] Campbell Family Institute for Cancer Research, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Ng CK; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Perez-Ordonez B; Department of Pathology, University Health Network, Toronto, Ontario, Canada., Harding NJ; Informatics and Bio-Computing Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada., Alfaro J; 1] Informatics and Bio-Computing Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada. [2] Ontario Cancer Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Onatrio, Canada. [3] Campbell Family Institute for Cancer Research, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. [4] Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., Chu KC; Informatics and Bio-Computing Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada., Viale A; Integrated Genomics Operation, Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Fusco N; 1] Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA. [2] School of Pathology, University of Milan, Milan, Italy., da Cruz Paula A; 1] Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA. [2] Instituto Português de Oncologia, Oporto, Portugal., Marchio C; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Sakr RA; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Lim R; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Thompson LD; Department of Pathology, Kaiser Permanente, Woodland Hills Medical Center, Woodland Hills, California, USA., Chiosea SI; Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA., Seethala RR; Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA., Skalova A; Department of Pathology and Laboratory Medicine, Charles University in Prague, Plzen, Czech Republic., Stelow EB; Department of Pathology, University of Virginia Medical Center, Charlottesville, Virginia, USA., Fonseca I; 1] Instituto Português de Oncologia Francisco Gentil, Lisbon, Portugal. [2] Faculdade de Medicina de Lisboa, Lisbon, Portugal., Assaad A; Department of Pathology, Virginia Mason Hospital and Seattle Medical Center, Seattle, Washington, USA., How C; 1] Ontario Cancer Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Onatrio, Canada. [2] Campbell Family Institute for Cancer Research, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Wang J; Informatics and Bio-Computing Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada., de Borja R; Informatics and Bio-Computing Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada., Chan-Seng-Yue M; Informatics and Bio-Computing Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada., Howlett CJ; Western University, London, Ontario, Canada., Nichols AC; Western University, London, Ontario, Canada., Wen YH; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Katabi N; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Buchner N; Cancer Genomics Platform, Ontario Institute for Cancer Research, Toronto, Ontario, Canada., Mullen L; Cancer Genomics Platform, Ontario Institute for Cancer Research, Toronto, Ontario, Canada., Kislinger T; 1] Ontario Cancer Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Onatrio, Canada. [2] Campbell Family Institute for Cancer Research, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. [3] Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., Wouters BG; 1] Ontario Cancer Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Onatrio, Canada. [2] Campbell Family Institute for Cancer Research, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. [3] Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., Liu FF; 1] Ontario Cancer Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Onatrio, Canada. [2] Campbell Family Institute for Cancer Research, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. [3] Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. [4] Department of Radiation Oncology, Princess Margaret Hospital and University of Toronto, Toronto, Ontario, Canada., Norton L; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA., McPherson JD; 1] Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. [2] Department of Pathology, Virginia Mason Hospital and Seattle Medical Center, Seattle, Washington, USA., Rubin BP; 1] Department of Molecular Genetics, Lerner Research Institute, Cleveland, Ohio, USA. [2] Robert J. Tomsich Pathology and Laboratory Medicine Institute, Taussig Cancer Center, Cleveland Clinic, Cleveland, Ohio, USA., Clarke BA; Department of Pathology, University Health Network, Toronto, Ontario, Canada., Weigelt B; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Boutros PC; 1] Informatics and Bio-Computing Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada. [2] Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. [3] Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada., Reis-Filho JS; 1] Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA. [2].
Source: Nature genetics [Nat Genet] 2014 Nov; Vol. 46 (11), pp. 1166-9. Date of Electronic Publication: 2014 Sep 21.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
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