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Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development.

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Title: Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development.
Authors: Mayers JR; Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA., Wu C; Department of Etiology and Carcinogenesis, Cancer Institute and Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA.; Department of Epidemiology, Harvard School of Public Health, Boston, MA., Clish CB; Broad Institute of MIT and Harvard University, Cambridge, MA., Kraft P; Department of Epidemiology, Harvard School of Public Health, Boston, MA.; Department of Biostatistics, Harvard School of Public Health, Boston, MA., Torrence ME; Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA., Fiske BP; Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA., Yuan C; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA., Bao Y; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA., Townsend MK; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA., Tworoger SS; Department of Epidemiology, Harvard School of Public Health, Boston, MA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA., Davidson SM; Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA., Papagiannakopoulos T; Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA., Yang A; Division of Genomic Stability and DNA repair, Department of Radiation Oncology, Dana- Farber Cancer Institute, Boston, MA 02215., Dayton TL; Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA., Ogino S; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA.; Department of Epidemiology, Harvard School of Public Health, Boston, MA.; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA., Stampfer MJ; Department of Epidemiology, Harvard School of Public Health, Boston, MA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.; Department of Nutrition, Harvard School of Public Health, Boston, MA., Giovannucci EL; Department of Epidemiology, Harvard School of Public Health, Boston, MA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.; Department of Nutrition, Harvard School of Public Health, Boston, MA., Qian ZR; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA., Rubinson DA; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA., Ma J; Department of Epidemiology, Harvard School of Public Health, Boston, MA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA., Sesso HD; Department of Epidemiology, Harvard School of Public Health, Boston, MA.; Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA., Gaziano JM; Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA.; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System., Cochrane BB; University of Washington School of Nursing, Seattle, WA., Liu S; Departments of Epidemiology and Medicine, Brown University, Providence, RI., Wactawski-Wende J; Department of Social and Preventive Medicine, University at Buffalo, SUNY, Buffalo, NY., Manson JE; Department of Epidemiology, Harvard School of Public Health, Boston, MA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.; Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA., Pollak MN; Departments of Oncology and Medicine, McGill University, Montreal, QC, Canada., Kimmelman AC; Division of Genomic Stability and DNA repair, Department of Radiation Oncology, Dana- Farber Cancer Institute, Boston, MA 02215., Souza A; Broad Institute of MIT and Harvard University, Cambridge, MA., Pierce K; Broad Institute of MIT and Harvard University, Cambridge, MA., Wang TJ; Division of Cardiovascular Medicine, Vanderbilt University, Nashville, TN., Gerszten RE; Broad Institute of MIT and Harvard University, Cambridge, MA.; Cardiology Division, Massachusetts General Hospital, and Harvard Medical School, Boston, MA., Fuchs CS; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA., Vander Heiden MG; Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA.; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA.; Broad Institute of MIT and Harvard University, Cambridge, MA., Wolpin BM; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA.; Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA.
Source: Nature medicine [Nat Med] 2014 Oct; Vol. 20 (10), pp. 1193-1198. Date of Electronic Publication: 2014 Sep 28.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
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