Identification of a novel drug lead that inhibits HCV infection and cell-to-cell transmission by targeting the HCV E2 glycoprotein.

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Title: Identification of a novel drug lead that inhibits HCV infection and cell-to-cell transmission by targeting the HCV E2 glycoprotein.
Authors: Al Olaby RR; Department of Chemistry, The American University in Cairo, New Cairo, Egypt., Cocquerel L; Center for Infection and Immunity of Lille, CNRS-UMR8204/Inserm-U1019, Pasteur Institute of Lille, University of Lille North of France, Lille, France., Zemla A; Pathogen Bioinformatics, Lawrence Livermore National Laboratory, Livermore, CA, United States of America., Saas L; Center for Infection and Immunity of Lille, CNRS-UMR8204/Inserm-U1019, Pasteur Institute of Lille, University of Lille North of France, Lille, France., Dubuisson J; Center for Infection and Immunity of Lille, CNRS-UMR8204/Inserm-U1019, Pasteur Institute of Lille, University of Lille North of France, Lille, France., Vielmetter J; Protein Expression Center, Beckman Institute, California Institute of Technology, Pasadena, CA, United States of America., Marcotrigiano J; Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ, United States of America., Khan AG; Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ, United States of America., Vences Catalan F; Department of Medicine, Stanford University Medical Center, Stanford, CA, United States of America., Perryman AL; Department of Medicine, Division of Infectious Diseases, Center for Emerging & Re-emerging Pathogens, Rutgers University-New Jersey Medical School, Newark, NJ, United States of America., Freundlich JS; Department of Medicine, Division of Infectious Diseases, Center for Emerging & Re-emerging Pathogens, Rutgers University-New Jersey Medical School, Newark, NJ, United States of America; Department of Pharmacology and Physiology, Rutgers University-New Jersey Medical School, Newark, NJ, United States of America., Forli S; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, United States of America., Levy S; Department of Medicine, Stanford University Medical Center, Stanford, CA, United States of America., Balhorn R; Department of Applied Science, University of California Davis, Davis, CA, United States of America., Azzazy HM; Department of Chemistry, The American University in Cairo, New Cairo, Egypt.
Source: PloS one [PLoS One] 2014 Oct 30; Vol. 9 (10), pp. e111333. Date of Electronic Publication: 2014 Oct 30 (Print Publication: 2014).
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Identification of a novel drug lead that inhibits HCV infection and cell-to-cell transmission by targeting the HCV E2 glycoprotein.
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  Data: <searchLink fieldCode="AU" term="%22Al+Olaby+RR%22">Al Olaby RR</searchLink>; Department of Chemistry, The American University in Cairo, New Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Cocquerel+L%22">Cocquerel L</searchLink>; Center for Infection and Immunity of Lille, CNRS-UMR8204/Inserm-U1019, Pasteur Institute of Lille, University of Lille North of France, Lille, France.<br /><searchLink fieldCode="AU" term="%22Zemla+A%22">Zemla A</searchLink>; Pathogen Bioinformatics, Lawrence Livermore National Laboratory, Livermore, CA, United States of America.<br /><searchLink fieldCode="AU" term="%22Saas+L%22">Saas L</searchLink>; Center for Infection and Immunity of Lille, CNRS-UMR8204/Inserm-U1019, Pasteur Institute of Lille, University of Lille North of France, Lille, France.<br /><searchLink fieldCode="AU" term="%22Dubuisson+J%22">Dubuisson J</searchLink>; Center for Infection and Immunity of Lille, CNRS-UMR8204/Inserm-U1019, Pasteur Institute of Lille, University of Lille North of France, Lille, France.<br /><searchLink fieldCode="AU" term="%22Vielmetter+J%22">Vielmetter J</searchLink>; Protein Expression Center, Beckman Institute, California Institute of Technology, Pasadena, CA, United States of America.<br /><searchLink fieldCode="AU" term="%22Marcotrigiano+J%22">Marcotrigiano J</searchLink>; Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ, United States of America.<br /><searchLink fieldCode="AU" term="%22Khan+AG%22">Khan AG</searchLink>; Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ, United States of America.<br /><searchLink fieldCode="AU" term="%22Vences+Catalan+F%22">Vences Catalan F</searchLink>; Department of Medicine, Stanford University Medical Center, Stanford, CA, United States of America.<br /><searchLink fieldCode="AU" term="%22Perryman+AL%22">Perryman AL</searchLink>; Department of Medicine, Division of Infectious Diseases, Center for Emerging & Re-emerging Pathogens, Rutgers University-New Jersey Medical School, Newark, NJ, United States of America.<br /><searchLink fieldCode="AU" term="%22Freundlich+JS%22">Freundlich JS</searchLink>; Department of Medicine, Division of Infectious Diseases, Center for Emerging & Re-emerging Pathogens, Rutgers University-New Jersey Medical School, Newark, NJ, United States of America; Department of Pharmacology and Physiology, Rutgers University-New Jersey Medical School, Newark, NJ, United States of America.<br /><searchLink fieldCode="AU" term="%22Forli+S%22">Forli S</searchLink>; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, United States of America.<br /><searchLink fieldCode="AU" term="%22Levy+S%22">Levy S</searchLink>; Department of Medicine, Stanford University Medical Center, Stanford, CA, United States of America.<br /><searchLink fieldCode="AU" term="%22Balhorn+R%22">Balhorn R</searchLink>; Department of Applied Science, University of California Davis, Davis, CA, United States of America.<br /><searchLink fieldCode="AU" term="%22Azzazy+HM%22">Azzazy HM</searchLink>; Department of Chemistry, The American University in Cairo, New Cairo, Egypt.
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