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Negamycin induces translational stalling and miscoding by binding to the small subunit head domain of the Escherichia coli ribosome.

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Title: Negamycin induces translational stalling and miscoding by binding to the small subunit head domain of the Escherichia coli ribosome.
Authors: Olivier NB; Discovery Sciences, AstraZeneca R&D Boston, Waltham, MA 02451;, Altman RB; Department of Physiology and Biophysics & the Tri-Institutional PhD Program in Chemical Biology, Weill Cornell Medical College, New York, NY 10065;, Noeske J; Department of Molecular Cell Biology, California Institute of Quantitative Biosciences, University of California, Berkeley, CA 94720; and., Basarab GS; Departments of Chemistry and., Code E; Discovery Sciences, AstraZeneca R&D Boston, Waltham, MA 02451;, Ferguson AD; Discovery Sciences, AstraZeneca R&D Boston, Waltham, MA 02451;, Gao N; Discovery Sciences, AstraZeneca R&D Boston, Waltham, MA 02451;, Huang J; Discovery Sciences, AstraZeneca R&D Boston, Waltham, MA 02451;, Juette MF; Department of Physiology and Biophysics & the Tri-Institutional PhD Program in Chemical Biology, Weill Cornell Medical College, New York, NY 10065;, Livchak S; Discovery Sciences, AstraZeneca R&D Boston, Waltham, MA 02451;, Miller MD; Departments of Chemistry and., Prince DB; Discovery Sciences, AstraZeneca R&D Boston, Waltham, MA 02451;, Cate JH; Department of Molecular Cell Biology, California Institute of Quantitative Biosciences, University of California, Berkeley, CA 94720; and., Buurman ET; Biosciences, Infection Innovative Medicines Unit, AstraZeneca R&D Boston, Waltham, MA 02451 scb2005@med.cornell.edu Ed.Buurman@astrazeneca.com., Blanchard SC; Department of Physiology and Biophysics & the Tri-Institutional PhD Program in Chemical Biology, Weill Cornell Medical College, New York, NY 10065; scb2005@med.cornell.edu Ed.Buurman@astrazeneca.com.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2014 Nov 18; Vol. 111 (46), pp. 16274-9. Date of Electronic Publication: 2014 Nov 03.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Negamycin induces translational stalling and miscoding by binding to the small subunit head domain of the Escherichia coli ribosome.
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