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Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS.

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Title: Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS.
Authors: Chouchani ET; MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK.; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, UK., Pell VR; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, UK., Gaude E; MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Box 197, Cambridge Biomedical Campus, Cambridge, CB2 0XZ, UK., Aksentijević D; King's College London, British Heart Foundation Centre of Excellence, The Rayne Institute, St Thomas' Hospital, London SE1 7EH, UK., Sundier SY; Department of Cell and Developmental Biology and UCL Consortium for Mitochondrial Biology, University College London, Gower Street, London WC1E 6BT, UK., Robb EL; MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK., Logan A; MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK., Nadtochiy SM; Department of Anesthesiology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA., Ord ENJ; Institute of Cardiovascular & Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA, UK., Smith AC; MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK., Eyassu F; MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK., Shirley R; Institute of Cardiovascular & Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA, UK., Hu CH; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, UK., Dare AJ; MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK., James AM; MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK., Rogatti S; MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK., Hartley RC; School of Chemistry, University of Glasgow, Glasgow, G12 8TA, UK., Eaton S; Unit of Paediatric Surgery, UCL Institute of Child Health, London, WC1N 1EH, UK., Costa ASH; MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Box 197, Cambridge Biomedical Campus, Cambridge, CB2 0XZ, UK., Brookes PS; Department of Anesthesiology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA., Davidson SM; Hatter Cardiovascular Institute, University College London, 67 Chenies Mews, London, WC1E 6HX, UK., Duchen MR; Department of Cell and Developmental Biology and UCL Consortium for Mitochondrial Biology, University College London, Gower Street, London WC1E 6BT, UK., Saeb-Parsy K; University Department of Surgery and Cambridge NIHR Biomedical Research Centre, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK., Shattock MJ; King's College London, British Heart Foundation Centre of Excellence, The Rayne Institute, St Thomas' Hospital, London SE1 7EH, UK., Robinson AJ; MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK., Work LM; Institute of Cardiovascular & Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA, UK., Frezza C; MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Box 197, Cambridge Biomedical Campus, Cambridge, CB2 0XZ, UK., Krieg T; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, UK., Murphy MP; MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK.
Source: Nature [Nature] 2014 Nov 20; Vol. 515 (7527), pp. 431-435. Date of Electronic Publication: 2014 Nov 05.
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Chouchani+ET%22">Chouchani ET</searchLink>; MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK.; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, UK.<br /><searchLink fieldCode="AU" term="%22Pell+VR%22">Pell VR</searchLink>; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, UK.<br /><searchLink fieldCode="AU" term="%22Gaude+E%22">Gaude E</searchLink>; MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Box 197, Cambridge Biomedical Campus, Cambridge, CB2 0XZ, UK.<br /><searchLink fieldCode="AU" term="%22Aksentijević+D%22">Aksentijević D</searchLink>; King's College London, British Heart Foundation Centre of Excellence, The Rayne Institute, St Thomas' Hospital, London SE1 7EH, UK.<br /><searchLink fieldCode="AU" term="%22Sundier+SY%22">Sundier SY</searchLink>; Department of Cell and Developmental Biology and UCL Consortium for Mitochondrial Biology, University College London, Gower Street, London WC1E 6BT, UK.<br /><searchLink fieldCode="AU" term="%22Robb+EL%22">Robb EL</searchLink>; MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK.<br /><searchLink fieldCode="AU" term="%22Logan+A%22">Logan A</searchLink>; MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK.<br /><searchLink fieldCode="AU" term="%22Nadtochiy+SM%22">Nadtochiy SM</searchLink>; Department of Anesthesiology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA.<br /><searchLink fieldCode="AU" term="%22Ord+ENJ%22">Ord ENJ</searchLink>; Institute of Cardiovascular & Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA, UK.<br /><searchLink fieldCode="AU" term="%22Smith+AC%22">Smith AC</searchLink>; MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK.<br /><searchLink fieldCode="AU" term="%22Eyassu+F%22">Eyassu F</searchLink>; MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK.<br /><searchLink fieldCode="AU" term="%22Shirley+R%22">Shirley R</searchLink>; Institute of Cardiovascular & Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA, UK.<br /><searchLink fieldCode="AU" term="%22Hu+CH%22">Hu CH</searchLink>; 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Department of Anesthesiology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA.<br /><searchLink fieldCode="AU" term="%22Davidson+SM%22">Davidson SM</searchLink>; Hatter Cardiovascular Institute, University College London, 67 Chenies Mews, London, WC1E 6HX, UK.<br /><searchLink fieldCode="AU" term="%22Duchen+MR%22">Duchen MR</searchLink>; Department of Cell and Developmental Biology and UCL Consortium for Mitochondrial Biology, University College London, Gower Street, London WC1E 6BT, UK.<br /><searchLink fieldCode="AU" term="%22Saeb-Parsy+K%22">Saeb-Parsy K</searchLink>; University Department of Surgery and Cambridge NIHR Biomedical Research Centre, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.<br /><searchLink fieldCode="AU" term="%22Shattock+MJ%22">Shattock MJ</searchLink>; King's College London, British Heart Foundation Centre of Excellence, The Rayne Institute, St Thomas' Hospital, London SE1 7EH, UK.<br /><searchLink fieldCode="AU" term="%22Robinson+AJ%22">Robinson AJ</searchLink>; MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK.<br /><searchLink fieldCode="AU" term="%22Work+LM%22">Work LM</searchLink>; Institute of Cardiovascular & Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA, UK.<br /><searchLink fieldCode="AU" term="%22Frezza+C%22">Frezza C</searchLink>; MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Box 197, Cambridge Biomedical Campus, Cambridge, CB2 0XZ, UK.<br /><searchLink fieldCode="AU" term="%22Krieg+T%22">Krieg T</searchLink>; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, UK.<br /><searchLink fieldCode="AU" term="%22Murphy+MP%22">Murphy MP</searchLink>; MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK.
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