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A cryo-electron microscopy study identifies the complete H16.V5 epitope and reveals global conformational changes initiated by binding of the neutralizing antibody fragment.

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Title: A cryo-electron microscopy study identifies the complete H16.V5 epitope and reveals global conformational changes initiated by binding of the neutralizing antibody fragment.
Authors: Lee H; Department of Medicine, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA., Brendle SA; Department of Pathology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA., Bywaters SM; Department of Pathology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA., Guan J; Department of Medicine, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA., Ashley RE; Department of Medicine, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA., Yoder JD; Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Makhov AM; Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Conway JF; Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Christensen ND; Department of Pathology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA., Hafenstein S; Department of Medicine, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA shafenstein@hmc.psu.edu.
Source: Journal of virology [J Virol] 2015 Jan 15; Vol. 89 (2), pp. 1428-38. Date of Electronic Publication: 2014 Nov 12.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0113724 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5514 (Electronic) Linking ISSN: 0022538X NLM ISO Abbreviation: J Virol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A cryo-electron microscopy study identifies the complete H16.V5 epitope and reveals global conformational changes initiated by binding of the neutralizing antibody fragment.
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  Data: <searchLink fieldCode="AU" term="%22Lee+H%22">Lee H</searchLink>; Department of Medicine, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Brendle+SA%22">Brendle SA</searchLink>; Department of Pathology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Bywaters+SM%22">Bywaters SM</searchLink>; Department of Pathology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Guan+J%22">Guan J</searchLink>; Department of Medicine, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Ashley+RE%22">Ashley RE</searchLink>; Department of Medicine, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Yoder+JD%22">Yoder JD</searchLink>; Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Makhov+AM%22">Makhov AM</searchLink>; Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Conway+JF%22">Conway JF</searchLink>; Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Christensen+ND%22">Christensen ND</searchLink>; Department of Pathology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Hafenstein+S%22">Hafenstein S</searchLink>; Department of Medicine, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA shafenstein@hmc.psu.edu.
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              Text: 2015 Jan 15
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