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Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis.

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Title: Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis.
Authors: Crane JD; 1] Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada. [2] Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada., Palanivel R; 1] Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada. [2] Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada. [3] Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada., Mottillo EP; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada., Bujak AL; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada., Wang H; 1] Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada. [2] Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada., Ford RJ; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada., Collins A; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada., Blümer RM; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada., Fullerton MD; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada., Yabut JM; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada., Kim JJ; 1] Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada. [2] Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada., Ghia JE; Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada., Hamza SM; Cardiovascular Research Centre, Alberta Diabetes Institute, Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada., Morrison KM; Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada., Schertzer JD; 1] Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada. [2] Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Dyck JR; Cardiovascular Research Centre, Alberta Diabetes Institute, Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada., Khan WI; 1] Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada. [2] Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada., Steinberg GR; 1] Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada. [2] Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.
Source: Nature medicine [Nat Med] 2015 Feb; Vol. 21 (2), pp. 166-72. Date of Electronic Publication: 2014 Dec 08.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Crane+JD%22">Crane JD</searchLink>; 1] Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada. [2] Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Palanivel+R%22">Palanivel R</searchLink>; 1] Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada. [2] Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada. [3] Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Mottillo+EP%22">Mottillo EP</searchLink>; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Bujak+AL%22">Bujak AL</searchLink>; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; 1] Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada. [2] Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Ford+RJ%22">Ford RJ</searchLink>; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Collins+A%22">Collins A</searchLink>; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Blümer+RM%22">Blümer RM</searchLink>; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Fullerton+MD%22">Fullerton MD</searchLink>; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Yabut+JM%22">Yabut JM</searchLink>; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Kim+JJ%22">Kim JJ</searchLink>; 1] Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada. [2] Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Ghia+JE%22">Ghia JE</searchLink>; Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Hamza+SM%22">Hamza SM</searchLink>; Cardiovascular Research Centre, Alberta Diabetes Institute, Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Morrison+KM%22">Morrison KM</searchLink>; Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Schertzer+JD%22">Schertzer JD</searchLink>; 1] Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada. [2] Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Dyck+JR%22">Dyck JR</searchLink>; Cardiovascular Research Centre, Alberta Diabetes Institute, Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Khan+WI%22">Khan WI</searchLink>; 1] Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada. [2] Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Steinberg+GR%22">Steinberg GR</searchLink>; 1] Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada. [2] Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.
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