An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA.

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Title: An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA.
Authors: Demaria M; Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA., Ohtani N; Division of Cancer Biology, The Japanese Foundation for Cancer Research, Koto-ku, Tokyo 135-8550, Japan., Youssef SA; Department of Pathobiology, Dutch Molecular Pathology Center, Faculty of Veterinary Medicine, Utrecht University, Utrecht 3509, the Netherlands., Rodier F; Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA., Toussaint W; CGC Department of Genetics, Erasmus Medical Center, Rotterdam 12306, the Netherlands., Mitchell JR; CGC Department of Genetics, Erasmus Medical Center, Rotterdam 12306, the Netherlands., Laberge RM; Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA., Vijg J; Department of Genetics, Albert Einstein College of Medicine, 1301 Morris Park Avenue, Bronx, NY 10461, USA., Van Steeg H; Department of Toxicogenetics, Leiden University Medical Center, Leiden 2318 NN, the Netherlands; National Institute of Public Health and the Environment (RIVM), Antonie van Leeuwenhoeklaan 9, Bilthoven 3721 MA, the Netherlands., Dollé ME; National Institute of Public Health and the Environment (RIVM), Antonie van Leeuwenhoeklaan 9, Bilthoven 3721 MA, the Netherlands., Hoeijmakers JH; CGC Department of Genetics, Erasmus Medical Center, Rotterdam 12306, the Netherlands., de Bruin A; Department of Pathobiology, Dutch Molecular Pathology Center, Faculty of Veterinary Medicine, Utrecht University, Utrecht 3509, the Netherlands., Hara E; Division of Cancer Biology, The Japanese Foundation for Cancer Research, Koto-ku, Tokyo 135-8550, Japan., Campisi J; Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA; Lawrence Berkeley National Laboratory, Life Sciences Division, 1 Cyclotron Road, Berkeley, CA 94720, USA. Electronic address: jcampisi@lbl.gov.
Source: Developmental cell [Dev Cell] 2014 Dec 22; Vol. 31 (6), pp. 722-33. Date of Electronic Publication: 2014 Dec 11.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101120028 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1551 (Electronic) Linking ISSN: 15345807 NLM ISO Abbreviation: Dev Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1878-1551
DOI:10.1016/j.devcel.2014.11.012