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Discovery of indole-derived pyridopyrazine-1,6-dione γ-secretase modulators that target presenilin.

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Title: Discovery of indole-derived pyridopyrazine-1,6-dione γ-secretase modulators that target presenilin.
Authors: Pettersson M; Pfizer Worldwide Research & Development, 610 Main Street, Cambridge, MA 02139, USA. Electronic address: martin.pettersson@pfizer.com., Johnson DS; Pfizer Worldwide Research & Development, 610 Main Street, Cambridge, MA 02139, USA., Humphrey JM; Eastern Point Road, Groton, CT 06340, USA., Am Ende CW; Eastern Point Road, Groton, CT 06340, USA., Evrard E; Pfizer Worldwide Research & Development, 610 Main Street, Cambridge, MA 02139, USA., Efremov I; Pfizer Worldwide Research & Development, 610 Main Street, Cambridge, MA 02139, USA., Kauffman GW; Pfizer Worldwide Research & Development, 610 Main Street, Cambridge, MA 02139, USA., Stepan AF; Pfizer Worldwide Research & Development, 610 Main Street, Cambridge, MA 02139, USA., Stiff CM; Eastern Point Road, Groton, CT 06340, USA., Xie L; Eastern Point Road, Groton, CT 06340, USA., Bales KR; Pfizer Worldwide Research & Development, 610 Main Street, Cambridge, MA 02139, USA., Hajos-Korcsok E; Pfizer Worldwide Research & Development, 610 Main Street, Cambridge, MA 02139, USA., Murrey HE; Pfizer Worldwide Research & Development, 610 Main Street, Cambridge, MA 02139, USA., Pustilnik LR; Eastern Point Road, Groton, CT 06340, USA., Steyn SJ; Pfizer Worldwide Research & Development, 610 Main Street, Cambridge, MA 02139, USA., Wood KM; Pfizer Worldwide Research & Development, 610 Main Street, Cambridge, MA 02139, USA., Verhoest PR; Pfizer Worldwide Research & Development, 610 Main Street, Cambridge, MA 02139, USA.
Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2015 Feb 15; Vol. 25 (4), pp. 908-13. Date of Electronic Publication: 2014 Dec 25.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Discovery of indole-derived pyridopyrazine-1,6-dione γ-secretase modulators that target presenilin.
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  Data: <searchLink fieldCode="AU" term="%22Pettersson+M%22">Pettersson M</searchLink>; Pfizer Worldwide Research & Development, 610 Main Street, Cambridge, MA 02139, USA. Electronic address: martin.pettersson@pfizer.com.<br /><searchLink fieldCode="AU" term="%22Johnson+DS%22">Johnson DS</searchLink>; Pfizer Worldwide Research & Development, 610 Main Street, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Humphrey+JM%22">Humphrey JM</searchLink>; Eastern Point Road, Groton, CT 06340, USA.<br /><searchLink fieldCode="AU" term="%22Am+Ende+CW%22">Am Ende CW</searchLink>; Eastern Point Road, Groton, CT 06340, USA.<br /><searchLink fieldCode="AU" term="%22Evrard+E%22">Evrard E</searchLink>; Pfizer Worldwide Research & Development, 610 Main Street, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Efremov+I%22">Efremov I</searchLink>; Pfizer Worldwide Research & Development, 610 Main Street, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Kauffman+GW%22">Kauffman GW</searchLink>; Pfizer Worldwide Research & Development, 610 Main Street, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Stepan+AF%22">Stepan AF</searchLink>; Pfizer Worldwide Research & Development, 610 Main Street, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Stiff+CM%22">Stiff CM</searchLink>; Eastern Point Road, Groton, CT 06340, USA.<br /><searchLink fieldCode="AU" term="%22Xie+L%22">Xie L</searchLink>; Eastern Point Road, Groton, CT 06340, USA.<br /><searchLink fieldCode="AU" term="%22Bales+KR%22">Bales KR</searchLink>; Pfizer Worldwide Research & Development, 610 Main Street, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Hajos-Korcsok+E%22">Hajos-Korcsok E</searchLink>; Pfizer Worldwide Research & Development, 610 Main Street, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Murrey+HE%22">Murrey HE</searchLink>; Pfizer Worldwide Research & Development, 610 Main Street, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Pustilnik+LR%22">Pustilnik LR</searchLink>; Eastern Point Road, Groton, CT 06340, USA.<br /><searchLink fieldCode="AU" term="%22Steyn+SJ%22">Steyn SJ</searchLink>; Pfizer Worldwide Research & Development, 610 Main Street, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Wood+KM%22">Wood KM</searchLink>; Pfizer Worldwide Research & Development, 610 Main Street, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Verhoest+PR%22">Verhoest PR</searchLink>; Pfizer Worldwide Research & Development, 610 Main Street, Cambridge, MA 02139, USA.
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