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Discovery of AZD3147: a potent, selective dual inhibitor of mTORC1 and mTORC2.

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Title: Discovery of AZD3147: a potent, selective dual inhibitor of mTORC1 and mTORC2.
Authors: Pike KG; Oncology Innovative Medicines, AstraZeneca , Alderley Park, Macclesfield, Cheshire SK10 4TG, U.K., Morris J, Ruston L, Pass SL, Greenwood R, Williams EJ, Demeritt J, Culshaw JD, Gill K, Pass M, Finlay MR, Good CJ, Roberts CA, Currie GS, Blades K, Eden JM, Pearson SE
Source: Journal of medicinal chemistry [J Med Chem] 2015 Mar 12; Vol. 58 (5), pp. 2326-49. Date of Electronic Publication: 2015 Feb 18.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Discovery of AZD3147: a potent, selective dual inhibitor of mTORC1 and mTORC2.
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  Data: <searchLink fieldCode="AU" term="%22Pike+KG%22">Pike KG</searchLink>; Oncology Innovative Medicines, AstraZeneca , Alderley Park, Macclesfield, Cheshire SK10 4TG, U.K.<br /><searchLink fieldCode="AU" term="%22Morris+J%22">Morris J</searchLink><br /><searchLink fieldCode="AU" term="%22Ruston+L%22">Ruston L</searchLink><br /><searchLink fieldCode="AU" term="%22Pass+SL%22">Pass SL</searchLink><br /><searchLink fieldCode="AU" term="%22Greenwood+R%22">Greenwood R</searchLink><br /><searchLink fieldCode="AU" term="%22Williams+EJ%22">Williams EJ</searchLink><br /><searchLink fieldCode="AU" term="%22Demeritt+J%22">Demeritt J</searchLink><br /><searchLink fieldCode="AU" term="%22Culshaw+JD%22">Culshaw JD</searchLink><br /><searchLink fieldCode="AU" term="%22Gill+K%22">Gill K</searchLink><br /><searchLink fieldCode="AU" term="%22Pass+M%22">Pass M</searchLink><br /><searchLink fieldCode="AU" term="%22Finlay+MR%22">Finlay MR</searchLink><br /><searchLink fieldCode="AU" term="%22Good+CJ%22">Good CJ</searchLink><br /><searchLink fieldCode="AU" term="%22Roberts+CA%22">Roberts CA</searchLink><br /><searchLink fieldCode="AU" term="%22Currie+GS%22">Currie GS</searchLink><br /><searchLink fieldCode="AU" term="%22Blades+K%22">Blades K</searchLink><br /><searchLink fieldCode="AU" term="%22Eden+JM%22">Eden JM</searchLink><br /><searchLink fieldCode="AU" term="%22Pearson+SE%22">Pearson SE</searchLink>
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2015 Mar 12; Vol. 58 (5), pp. 2326-49. <i>Date of Electronic Publication: </i>2015 Feb 18.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1021/jm501778s
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        Text: English
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      – TitleFull: Discovery of AZD3147: a potent, selective dual inhibitor of mTORC1 and mTORC2.
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              Text: 2015 Mar 12
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