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A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.

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Title: A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.
Authors: Coll RC; 1] School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland. [2] Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia., Robertson AA; Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia., Chae JJ; Inflammatory Disease Section, Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA., Higgins SC; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Muñoz-Planillo R; Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan, USA., Inserra MC; 1] Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia. [2] School of Pharmacy, University of Queensland, Brisbane, Australia., Vetter I; 1] Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia. [2] School of Pharmacy, University of Queensland, Brisbane, Australia., Dungan LS; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Monks BG; Institute of Innate Immunity, University Hospital, University of Bonn, Bonn, Germany., Stutz A; Institute of Innate Immunity, University Hospital, University of Bonn, Bonn, Germany., Croker DE; Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia., Butler MS; Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia., Haneklaus M; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Sutton CE; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Núñez G; Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan, USA., Latz E; 1] Institute of Innate Immunity, University Hospital, University of Bonn, Bonn, Germany. [2] Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, USA. [3] German Center for Neurodegenerative Diseases, Bonn, Germany., Kastner DL; Inflammatory Disease Section, Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA., Mills KH; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Masters SL; The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia., Schroder K; Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia., Cooper MA; Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia., O'Neill LA; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
Source: Nature medicine [Nat Med] 2015 Mar; Vol. 21 (3), pp. 248-55. Date of Electronic Publication: 2015 Feb 16.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.
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  Data: <searchLink fieldCode="AU" term="%22Coll+RC%22">Coll RC</searchLink>; 1] School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland. [2] Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia.<br /><searchLink fieldCode="AU" term="%22Robertson+AA%22">Robertson AA</searchLink>; Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia.<br /><searchLink fieldCode="AU" term="%22Chae+JJ%22">Chae JJ</searchLink>; Inflammatory Disease Section, Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Higgins+SC%22">Higgins SC</searchLink>; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Muñoz-Planillo+R%22">Muñoz-Planillo R</searchLink>; Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Inserra+MC%22">Inserra MC</searchLink>; 1] Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia. [2] School of Pharmacy, University of Queensland, Brisbane, Australia.<br /><searchLink fieldCode="AU" term="%22Vetter+I%22">Vetter I</searchLink>; 1] Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia. [2] School of Pharmacy, University of Queensland, Brisbane, Australia.<br /><searchLink fieldCode="AU" term="%22Dungan+LS%22">Dungan LS</searchLink>; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Monks+BG%22">Monks BG</searchLink>; Institute of Innate Immunity, University Hospital, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Stutz+A%22">Stutz A</searchLink>; Institute of Innate Immunity, University Hospital, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Croker+DE%22">Croker DE</searchLink>; Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia.<br /><searchLink fieldCode="AU" term="%22Butler+MS%22">Butler MS</searchLink>; Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia.<br /><searchLink fieldCode="AU" term="%22Haneklaus+M%22">Haneklaus M</searchLink>; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Sutton+CE%22">Sutton CE</searchLink>; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Núñez+G%22">Núñez G</searchLink>; Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Latz+E%22">Latz E</searchLink>; 1] Institute of Innate Immunity, University Hospital, University of Bonn, Bonn, Germany. [2] Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, USA. [3] German Center for Neurodegenerative Diseases, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Kastner+DL%22">Kastner DL</searchLink>; Inflammatory Disease Section, Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Mills+KH%22">Mills KH</searchLink>; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Masters+SL%22">Masters SL</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.<br /><searchLink fieldCode="AU" term="%22Schroder+K%22">Schroder K</searchLink>; Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia.<br /><searchLink fieldCode="AU" term="%22Cooper+MA%22">Cooper MA</searchLink>; Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia.<br /><searchLink fieldCode="AU" term="%22O'Neill+LA%22">O'Neill LA</searchLink>; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
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  Data: <searchLink fieldCode="JN" term="%229502015%22">Nature medicine</searchLink> [Nat Med] 2015 Mar; Vol. 21 (3), pp. 248-55. <i>Date of Electronic Publication: </i>2015 Feb 16.
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