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Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers.

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Title: Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers.
Authors: Onengut-Gumuscu S; 1] Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA. [2] Department of Medicine, Division of Endocrinology, University of Virginia, Charlottesville, Virginia, USA., Chen WM; 1] Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA. [2] Department of Public Health Sciences, Division of Biostatistics and Epidemiology, University of Virginia, Charlottesville, Virginia, USA., Burren O; Juvenile Diabetes Research Foundation (JDRF)/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research (NIHR) Biomedical Research Centre, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., Cooper NJ; Juvenile Diabetes Research Foundation (JDRF)/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research (NIHR) Biomedical Research Centre, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., Quinlan AR; 1] Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA. [2] Department of Public Health Sciences, Division of Biostatistics and Epidemiology, University of Virginia, Charlottesville, Virginia, USA., Mychaleckyj JC; 1] Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA. [2] Department of Public Health Sciences, Division of Biostatistics and Epidemiology, University of Virginia, Charlottesville, Virginia, USA., Farber E; Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA., Bonnie JK; Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA., Szpak M; Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA., Schofield E; Juvenile Diabetes Research Foundation (JDRF)/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research (NIHR) Biomedical Research Centre, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., Achuthan P; Juvenile Diabetes Research Foundation (JDRF)/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research (NIHR) Biomedical Research Centre, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., Guo H; Juvenile Diabetes Research Foundation (JDRF)/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research (NIHR) Biomedical Research Centre, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., Fortune MD; Juvenile Diabetes Research Foundation (JDRF)/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research (NIHR) Biomedical Research Centre, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., Stevens H; Juvenile Diabetes Research Foundation (JDRF)/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research (NIHR) Biomedical Research Centre, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., Walker NM; Juvenile Diabetes Research Foundation (JDRF)/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research (NIHR) Biomedical Research Centre, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., Ward LD; 1] Department of Computer Science, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA. [2] Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Kundaje A; 1] Department of Computer Science, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA. [2] Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. [3] Department of Genetics, Stanford University, Stanford, California, USA. [4] Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA., Kellis M; 1] Department of Computer Science, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA. [2] Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Daly MJ; 1] Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. [2] Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA., Barrett JC; Wellcome Trust Sanger Institute, Hinxton, UK., Cooper JD; Juvenile Diabetes Research Foundation (JDRF)/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research (NIHR) Biomedical Research Centre, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., Deloukas P; Wellcome Trust Sanger Institute, Hinxton, UK., Todd JA; Juvenile Diabetes Research Foundation (JDRF)/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research (NIHR) Biomedical Research Centre, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., Wallace C; 1] Juvenile Diabetes Research Foundation (JDRF)/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research (NIHR) Biomedical Research Centre, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK. [2] Medical Research Council (MRC) Biostatistics Unit, Institute of Public Health, University Forvie Site, Cambridge, UK., Concannon P; Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA., Rich SS; 1] Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA. [2] Department of Public Health Sciences, Division of Biostatistics and Epidemiology, University of Virginia, Charlottesville, Virginia, USA.
Corporate Authors: Type 1 Diabetes Genetics Consortium
Source: Nature genetics [Nat Genet] 2015 Apr; Vol. 47 (4), pp. 381-6. Date of Electronic Publication: 2015 Mar 09.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
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  Data: Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers.
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  Data: <searchLink fieldCode="AU" term="%22Onengut-Gumuscu+S%22">Onengut-Gumuscu S</searchLink>; 1] Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA. [2] Department of Medicine, Division of Endocrinology, University of Virginia, Charlottesville, Virginia, USA.<br /><searchLink fieldCode="AU" term="%22Chen+WM%22">Chen WM</searchLink>; 1] Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA. [2] Department of Public Health Sciences, Division of Biostatistics and Epidemiology, University of Virginia, Charlottesville, Virginia, USA.<br /><searchLink fieldCode="AU" term="%22Burren+O%22">Burren O</searchLink>; Juvenile Diabetes Research Foundation (JDRF)/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research (NIHR) Biomedical Research Centre, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Cooper+NJ%22">Cooper NJ</searchLink>; Juvenile Diabetes Research Foundation (JDRF)/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research (NIHR) Biomedical Research Centre, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Quinlan+AR%22">Quinlan AR</searchLink>; 1] Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA. [2] Department of Public Health Sciences, Division of Biostatistics and Epidemiology, University of Virginia, Charlottesville, Virginia, USA.<br /><searchLink fieldCode="AU" term="%22Mychaleckyj+JC%22">Mychaleckyj JC</searchLink>; 1] Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA. 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[2] Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Kundaje+A%22">Kundaje A</searchLink>; 1] Department of Computer Science, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA. [2] Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. [3] Department of Genetics, Stanford University, Stanford, California, USA. [4] Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Kellis+M%22">Kellis M</searchLink>; 1] Department of Computer Science, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA. [2] Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Daly+MJ%22">Daly MJ</searchLink>; 1] Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. [2] Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Barrett+JC%22">Barrett JC</searchLink>; Wellcome Trust Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Cooper+JD%22">Cooper JD</searchLink>; Juvenile Diabetes Research Foundation (JDRF)/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research (NIHR) Biomedical Research Centre, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Deloukas+P%22">Deloukas P</searchLink>; Wellcome Trust Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Todd+JA%22">Todd JA</searchLink>; Juvenile Diabetes Research Foundation (JDRF)/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research (NIHR) Biomedical Research Centre, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Wallace+C%22">Wallace C</searchLink>; 1] Juvenile Diabetes Research Foundation (JDRF)/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research (NIHR) Biomedical Research Centre, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK. [2] Medical Research Council (MRC) Biostatistics Unit, Institute of Public Health, University Forvie Site, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Concannon+P%22">Concannon P</searchLink>; Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA.<br /><searchLink fieldCode="AU" term="%22Rich+SS%22">Rich SS</searchLink>; 1] Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA. [2] Department of Public Health Sciences, Division of Biostatistics and Epidemiology, University of Virginia, Charlottesville, Virginia, USA.
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