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Development of a LC-MS/MS method for simultaneous determination of metoprolol and its metabolites, α-hydroxymetoprolol and O-desmethylmetoprolol, in rat plasma: application to the herb-drug interaction study of metoprolol and breviscapine.

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Title: Development of a LC-MS/MS method for simultaneous determination of metoprolol and its metabolites, α-hydroxymetoprolol and O-desmethylmetoprolol, in rat plasma: application to the herb-drug interaction study of metoprolol and breviscapine.
Authors: Rao Z; Department of Pharmacy, the First Hospital of Lanzhou University, Lanzhou, 730000, China., Ma YR; Department of Pharmacy, the First Hospital of Lanzhou University, Lanzhou, 730000, China.; School of Pharmacy, Lanzhou University, Lanzhou, 730000, China., Qin HY; Department of Pharmacy, the First Hospital of Lanzhou University, Lanzhou, 730000, China., Wang YF; Department of Pharmacy, the First Hospital of Lanzhou University, Lanzhou, 730000, China.; School of Pharmacy, Lanzhou University, Lanzhou, 730000, China.; Department of Pharmacy, Qinhai Provincial Hospital, Xining, 810007, China., Wei YH; Department of Pharmacy, the First Hospital of Lanzhou University, Lanzhou, 730000, China., Zhou Y; Department of Pharmacy, the First Hospital of Lanzhou University, Lanzhou, 730000, China., Zhang GQ; Department of Pharmacy, the First Hospital of Lanzhou University, Lanzhou, 730000, China., Wang XD; Department of Pharmacy, the First Hospital of Lanzhou University, Lanzhou, 730000, China.; School of Pharmacy, Lanzhou University, Lanzhou, 730000, China., Wu XA; Department of Pharmacy, the First Hospital of Lanzhou University, Lanzhou, 730000, China.
Source: Biomedical chromatography : BMC [Biomed Chromatogr] 2015 Sep; Vol. 29 (9), pp. 1453-60. Date of Electronic Publication: 2015 Mar 04.
Publication Type: Evaluation Study; Journal Article
Journal Info: Publisher: Wiley Country of Publication: England NLM ID: 8610241 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1099-0801 (Electronic) Linking ISSN: 02693879 NLM ISO Abbreviation: Biomed Chromatogr Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Development of a LC-MS/MS method for simultaneous determination of metoprolol and its metabolites, α-hydroxymetoprolol and O-desmethylmetoprolol, in rat plasma: application to the herb-drug interaction study of metoprolol and breviscapine.
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  Data: <searchLink fieldCode="AU" term="%22Rao+Z%22">Rao Z</searchLink>; Department of Pharmacy, the First Hospital of Lanzhou University, Lanzhou, 730000, China.<br /><searchLink fieldCode="AU" term="%22Ma+YR%22">Ma YR</searchLink>; Department of Pharmacy, the First Hospital of Lanzhou University, Lanzhou, 730000, China.; School of Pharmacy, Lanzhou University, Lanzhou, 730000, China.<br /><searchLink fieldCode="AU" term="%22Qin+HY%22">Qin HY</searchLink>; Department of Pharmacy, the First Hospital of Lanzhou University, Lanzhou, 730000, China.<br /><searchLink fieldCode="AU" term="%22Wang+YF%22">Wang YF</searchLink>; Department of Pharmacy, the First Hospital of Lanzhou University, Lanzhou, 730000, China.; School of Pharmacy, Lanzhou University, Lanzhou, 730000, China.; Department of Pharmacy, Qinhai Provincial Hospital, Xining, 810007, China.<br /><searchLink fieldCode="AU" term="%22Wei+YH%22">Wei YH</searchLink>; Department of Pharmacy, the First Hospital of Lanzhou University, Lanzhou, 730000, China.<br /><searchLink fieldCode="AU" term="%22Zhou+Y%22">Zhou Y</searchLink>; Department of Pharmacy, the First Hospital of Lanzhou University, Lanzhou, 730000, China.<br /><searchLink fieldCode="AU" term="%22Zhang+GQ%22">Zhang GQ</searchLink>; Department of Pharmacy, the First Hospital of Lanzhou University, Lanzhou, 730000, China.<br /><searchLink fieldCode="AU" term="%22Wang+XD%22">Wang XD</searchLink>; Department of Pharmacy, the First Hospital of Lanzhou University, Lanzhou, 730000, China.; School of Pharmacy, Lanzhou University, Lanzhou, 730000, China.<br /><searchLink fieldCode="AU" term="%22Wu+XA%22">Wu XA</searchLink>; Department of Pharmacy, the First Hospital of Lanzhou University, Lanzhou, 730000, China.
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  Data: <searchLink fieldCode="JN" term="%228610241%22">Biomedical chromatography : BMC</searchLink> [Biomed Chromatogr] 2015 Sep; Vol. 29 (9), pp. 1453-60. <i>Date of Electronic Publication: </i>2015 Mar 04.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley%22">Wiley </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>8610241 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1099-0801 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2202693879%22">02693879 </searchLink><i>NLM ISO Abbreviation: </i>Biomed Chromatogr <i>Subsets: </i>MEDLINE
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        Value: 10.1002/bmc.3445
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      – Code: eng
        Text: English
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        StartPage: 1453
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      – TitleFull: Development of a LC-MS/MS method for simultaneous determination of metoprolol and its metabolites, α-hydroxymetoprolol and O-desmethylmetoprolol, in rat plasma: application to the herb-drug interaction study of metoprolol and breviscapine.
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            NameFull: Rao Z
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            – D: 01
              M: 09
              Text: 2015 Sep
              Type: published
              Y: 2015
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            – TitleFull: Biomedical chromatography : BMC
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