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Development of a LC-MS/MS method for simultaneous determination of metoprolol and its metabolites, α-hydroxymetoprolol and O-desmethylmetoprolol, in rat plasma: application to the herb-drug interaction study of metoprolol and breviscapine.

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Title: Development of a LC-MS/MS method for simultaneous determination of metoprolol and its metabolites, α-hydroxymetoprolol and O-desmethylmetoprolol, in rat plasma: application to the herb-drug interaction study of metoprolol and breviscapine.
Authors: Rao Z; Department of Pharmacy, the First Hospital of Lanzhou University, Lanzhou, 730000, China., Ma YR; Department of Pharmacy, the First Hospital of Lanzhou University, Lanzhou, 730000, China.; School of Pharmacy, Lanzhou University, Lanzhou, 730000, China., Qin HY; Department of Pharmacy, the First Hospital of Lanzhou University, Lanzhou, 730000, China., Wang YF; Department of Pharmacy, the First Hospital of Lanzhou University, Lanzhou, 730000, China.; School of Pharmacy, Lanzhou University, Lanzhou, 730000, China.; Department of Pharmacy, Qinhai Provincial Hospital, Xining, 810007, China., Wei YH; Department of Pharmacy, the First Hospital of Lanzhou University, Lanzhou, 730000, China., Zhou Y; Department of Pharmacy, the First Hospital of Lanzhou University, Lanzhou, 730000, China., Zhang GQ; Department of Pharmacy, the First Hospital of Lanzhou University, Lanzhou, 730000, China., Wang XD; Department of Pharmacy, the First Hospital of Lanzhou University, Lanzhou, 730000, China.; School of Pharmacy, Lanzhou University, Lanzhou, 730000, China., Wu XA; Department of Pharmacy, the First Hospital of Lanzhou University, Lanzhou, 730000, China.
Source: Biomedical chromatography : BMC [Biomed Chromatogr] 2015 Sep; Vol. 29 (9), pp. 1453-60. Date of Electronic Publication: 2015 Mar 04.
Publication Type: Evaluation Study; Journal Article
Journal Info: Publisher: Wiley Country of Publication: England NLM ID: 8610241 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1099-0801 (Electronic) Linking ISSN: 02693879 NLM ISO Abbreviation: Biomed Chromatogr Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1099-0801
DOI:10.1002/bmc.3445