View in EDS PDF Full Text

A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models.

Saved in:
Bibliographic Details
Title: A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models.
Authors: Chan-Penebre E; Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, Massachusetts, USA., Kuplast KG; Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, Massachusetts, USA., Majer CR; Warp Drive Bio, Cambridge, Massachusetts, USA., Boriack-Sjodin PA; Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, Massachusetts, USA., Wigle TJ; Warp Drive Bio, Cambridge, Massachusetts, USA., Johnston LD; Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, Massachusetts, USA., Rioux N; Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, Massachusetts, USA., Munchhof MJ; Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, Massachusetts, USA., Jin L; Agile Biostructure Solutions, Cambridge, Massachusetts, USA., Jacques SL; Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, Massachusetts, USA., West KA; Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, Massachusetts, USA., Lingaraj T; Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, Massachusetts, USA., Stickland K; Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, Massachusetts, USA., Ribich SA; Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, Massachusetts, USA., Raimondi A; Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, Massachusetts, USA., Scott MP; Genentech, San Francisco, California, USA., Waters NJ; Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, Massachusetts, USA., Pollock RM; Warp Drive Bio, Cambridge, Massachusetts, USA., Smith JJ; Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, Massachusetts, USA., Barbash O; Cancer Epigenetics DPU, GlaxoSmithKline, Collegeville, Pennsylvania, USA., Pappalardi M; Cancer Epigenetics DPU, GlaxoSmithKline, Collegeville, Pennsylvania, USA., Ho TF; Department of Biological Reagents and Assay Development, GlaxoSmithKline, Collegeville, Pennsylvania, USA., Nurse K; Department of Biological Reagents and Assay Development, GlaxoSmithKline, Collegeville, Pennsylvania, USA., Oza KP; Department of Biological Reagents and Assay Development, GlaxoSmithKline, Collegeville, Pennsylvania, USA., Gallagher KT; Discovery Core Technologies and Capabilities, GlaxoSmithKline, Collegeville, Pennsylvania, USA., Kruger R; Cancer Epigenetics DPU, GlaxoSmithKline, Collegeville, Pennsylvania, USA., Moyer MP; Raze Therapeutics, Cambridge, Massachusetts, USA., Copeland RA; Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, Massachusetts, USA., Chesworth R; Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, Massachusetts, USA., Duncan KW; Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, Massachusetts, USA.
Source: Nature chemical biology [Nat Chem Biol] 2015 Jun; Vol. 11 (6), pp. 432-7. Date of Electronic Publication: 2015 Apr 27.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Links:
  – Type: pdflink
Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 25915199
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Chan-Penebre+E%22">Chan-Penebre E</searchLink>; Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Kuplast+KG%22">Kuplast KG</searchLink>; Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Majer+CR%22">Majer CR</searchLink>; Warp Drive Bio, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Boriack-Sjodin+PA%22">Boriack-Sjodin PA</searchLink>; Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Wigle+TJ%22">Wigle TJ</searchLink>; Warp Drive Bio, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Johnston+LD%22">Johnston LD</searchLink>; Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Rioux+N%22">Rioux N</searchLink>; Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Munchhof+MJ%22">Munchhof MJ</searchLink>; Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Jin+L%22">Jin L</searchLink>; Agile Biostructure Solutions, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Jacques+SL%22">Jacques SL</searchLink>; Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22West+KA%22">West KA</searchLink>; Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Lingaraj+T%22">Lingaraj T</searchLink>; Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Stickland+K%22">Stickland K</searchLink>; Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Ribich+SA%22">Ribich SA</searchLink>; Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Raimondi+A%22">Raimondi A</searchLink>; Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Scott+MP%22">Scott MP</searchLink>; Genentech, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Waters+NJ%22">Waters NJ</searchLink>; Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Pollock+RM%22">Pollock RM</searchLink>; Warp Drive Bio, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Smith+JJ%22">Smith JJ</searchLink>; Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Barbash+O%22">Barbash O</searchLink>; Cancer Epigenetics DPU, GlaxoSmithKline, Collegeville, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Pappalardi+M%22">Pappalardi M</searchLink>; Cancer Epigenetics DPU, GlaxoSmithKline, Collegeville, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Ho+TF%22">Ho TF</searchLink>; Department of Biological Reagents and Assay Development, GlaxoSmithKline, Collegeville, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Nurse+K%22">Nurse K</searchLink>; Department of Biological Reagents and Assay Development, GlaxoSmithKline, Collegeville, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Oza+KP%22">Oza KP</searchLink>; Department of Biological Reagents and Assay Development, GlaxoSmithKline, Collegeville, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Gallagher+KT%22">Gallagher KT</searchLink>; Discovery Core Technologies and Capabilities, GlaxoSmithKline, Collegeville, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Kruger+R%22">Kruger R</searchLink>; Cancer Epigenetics DPU, GlaxoSmithKline, Collegeville, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Moyer+MP%22">Moyer MP</searchLink>; Raze Therapeutics, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Copeland+RA%22">Copeland RA</searchLink>; Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Chesworth+R%22">Chesworth R</searchLink>; Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Duncan+KW%22">Duncan KW</searchLink>; Departments of Biology and Molecular Discovery, Epizyme, Inc., Cambridge, Massachusetts, USA.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101231976%22">Nature chemical biology</searchLink> [Nat Chem Biol] 2015 Jun; Vol. 11 (6), pp. 432-7. <i>Date of Electronic Publication: </i>2015 Apr 27.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101231976 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1552-4469 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215524450%22">15524450 </searchLink><i>NLM ISO Abbreviation: </i>Nat Chem Biol <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=25915199
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/nchembio.1810
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 432
    Titles:
      – TitleFull: A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Chan-Penebre E
      – PersonEntity:
          Name:
            NameFull: Kuplast KG
      – PersonEntity:
          Name:
            NameFull: Majer CR
      – PersonEntity:
          Name:
            NameFull: Boriack-Sjodin PA
      – PersonEntity:
          Name:
            NameFull: Wigle TJ
      – PersonEntity:
          Name:
            NameFull: Johnston LD
      – PersonEntity:
          Name:
            NameFull: Rioux N
      – PersonEntity:
          Name:
            NameFull: Munchhof MJ
      – PersonEntity:
          Name:
            NameFull: Jin L
      – PersonEntity:
          Name:
            NameFull: Jacques SL
      – PersonEntity:
          Name:
            NameFull: West KA
      – PersonEntity:
          Name:
            NameFull: Lingaraj T
      – PersonEntity:
          Name:
            NameFull: Stickland K
      – PersonEntity:
          Name:
            NameFull: Ribich SA
      – PersonEntity:
          Name:
            NameFull: Raimondi A
      – PersonEntity:
          Name:
            NameFull: Scott MP
      – PersonEntity:
          Name:
            NameFull: Waters NJ
      – PersonEntity:
          Name:
            NameFull: Pollock RM
      – PersonEntity:
          Name:
            NameFull: Smith JJ
      – PersonEntity:
          Name:
            NameFull: Barbash O
      – PersonEntity:
          Name:
            NameFull: Pappalardi M
      – PersonEntity:
          Name:
            NameFull: Ho TF
      – PersonEntity:
          Name:
            NameFull: Nurse K
      – PersonEntity:
          Name:
            NameFull: Oza KP
      – PersonEntity:
          Name:
            NameFull: Gallagher KT
      – PersonEntity:
          Name:
            NameFull: Kruger R
      – PersonEntity:
          Name:
            NameFull: Moyer MP
      – PersonEntity:
          Name:
            NameFull: Copeland RA
      – PersonEntity:
          Name:
            NameFull: Chesworth R
      – PersonEntity:
          Name:
            NameFull: Duncan KW
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 06
              Text: 2015 Jun
              Type: published
              Y: 2015
          Identifiers:
            – Type: issn-electronic
              Value: 1552-4469
          Numbering:
            – Type: volume
              Value: 11
            – Type: issue
              Value: 6
          Titles:
            – TitleFull: Nature chemical biology
              Type: main
ResultId 1