Activation of MET via diverse exon 14 splicing alterations occurs in multiple tumor types and confers clinical sensitivity to MET inhibitors.
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| Title: | Activation of MET via diverse exon 14 splicing alterations occurs in multiple tumor types and confers clinical sensitivity to MET inhibitors. |
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| Authors: | Frampton GM; Foundation Medicine Inc., Cambridge, Massachusetts. gframpton@foundationmedicine.com., Ali SM; Foundation Medicine Inc., Cambridge, Massachusetts., Rosenzweig M; Foundation Medicine Inc., Cambridge, Massachusetts., Chmielecki J; Foundation Medicine Inc., Cambridge, Massachusetts., Lu X; Division of Hematology and Oncology, Department of Medicine, University of California, San Francisco, San Francisco, California., Bauer TM; Sarah Cannon Research Institute/Tennessee Oncology, PLLC, Nashville, Tennessee., Akimov M; Novartis Pharma AG, Basel, Switzerland., Bufill JA; Michiana Hematology-Oncology, PC, Mishawaka, Indiana., Lee C; University of North Carolina School of Medicine, Clinical Research, Thoracic Oncology Program, Chapel Hill, North Carolina., Jentz D; South Bend Medical Foundation, South Bend, Indiana., Hoover R; South Bend Medical Foundation, South Bend, Indiana., Ou SH; Division of Hematology-Oncology, Department of Medicine, University of California Irvine School of Medicine, Irvine, California., Salgia R; The University of Chicago School of Medicine, Chicago, Illinois., Brennan T; Foundation Medicine Inc., Cambridge, Massachusetts., Chalmers ZR; Foundation Medicine Inc., Cambridge, Massachusetts., Jaeger S; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts., Huang A; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts., Elvin JA; Foundation Medicine Inc., Cambridge, Massachusetts., Erlich R; Foundation Medicine Inc., Cambridge, Massachusetts., Fichtenholtz A; Foundation Medicine Inc., Cambridge, Massachusetts., Gowen KA; Foundation Medicine Inc., Cambridge, Massachusetts., Greenbowe J; Foundation Medicine Inc., Cambridge, Massachusetts., Johnson A; Foundation Medicine Inc., Cambridge, Massachusetts., Khaira D; Foundation Medicine Inc., Cambridge, Massachusetts., McMahon C; Foundation Medicine Inc., Cambridge, Massachusetts., Sanford EM; Foundation Medicine Inc., Cambridge, Massachusetts., Roels S; Foundation Medicine Inc., Cambridge, Massachusetts., White J; Foundation Medicine Inc., Cambridge, Massachusetts., Greshock J; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts., Schlegel R; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts., Lipson D; Foundation Medicine Inc., Cambridge, Massachusetts., Yelensky R; Foundation Medicine Inc., Cambridge, Massachusetts., Morosini D; Foundation Medicine Inc., Cambridge, Massachusetts., Ross JS; Foundation Medicine Inc., Cambridge, Massachusetts., Collisson E; Division of Hematology and Oncology, Department of Medicine, University of California, San Francisco, San Francisco, California., Peters M; Novartis Pharma AG, Basel, Switzerland., Stephens PJ; Foundation Medicine Inc., Cambridge, Massachusetts., Miller VA; Foundation Medicine Inc., Cambridge, Massachusetts. |
| Source: | Cancer discovery [Cancer Discov] 2015 Aug; Vol. 5 (8), pp. 850-9. Date of Electronic Publication: 2015 May 13. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 25971938 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Activation of MET via diverse exon 14 splicing alterations occurs in multiple tumor types and confers clinical sensitivity to MET inhibitors. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Frampton+GM%22">Frampton GM</searchLink>; Foundation Medicine Inc., Cambridge, Massachusetts. gframpton@foundationmedicine.com.<br /><searchLink fieldCode="AU" term="%22Ali+SM%22">Ali SM</searchLink>; Foundation Medicine Inc., Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Rosenzweig+M%22">Rosenzweig M</searchLink>; Foundation Medicine Inc., Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Chmielecki+J%22">Chmielecki J</searchLink>; Foundation Medicine Inc., Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Lu+X%22">Lu X</searchLink>; Division of Hematology and Oncology, Department of Medicine, University of California, San Francisco, San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Bauer+TM%22">Bauer TM</searchLink>; Sarah Cannon Research Institute/Tennessee Oncology, PLLC, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Akimov+M%22">Akimov M</searchLink>; Novartis Pharma AG, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Bufill+JA%22">Bufill JA</searchLink>; Michiana Hematology-Oncology, PC, Mishawaka, Indiana.<br /><searchLink fieldCode="AU" term="%22Lee+C%22">Lee C</searchLink>; University of North Carolina School of Medicine, Clinical Research, Thoracic Oncology Program, Chapel Hill, North Carolina.<br /><searchLink fieldCode="AU" term="%22Jentz+D%22">Jentz D</searchLink>; South Bend Medical Foundation, South Bend, Indiana.<br /><searchLink fieldCode="AU" term="%22Hoover+R%22">Hoover R</searchLink>; South Bend Medical Foundation, South Bend, Indiana.<br /><searchLink fieldCode="AU" term="%22Ou+SH%22">Ou SH</searchLink>; Division of Hematology-Oncology, Department of Medicine, University of California Irvine School of Medicine, Irvine, California.<br /><searchLink fieldCode="AU" term="%22Salgia+R%22">Salgia R</searchLink>; The University of Chicago School of Medicine, Chicago, Illinois.<br /><searchLink fieldCode="AU" term="%22Brennan+T%22">Brennan T</searchLink>; Foundation Medicine Inc., Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Chalmers+ZR%22">Chalmers ZR</searchLink>; Foundation Medicine Inc., Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Jaeger+S%22">Jaeger S</searchLink>; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Huang+A%22">Huang A</searchLink>; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Elvin+JA%22">Elvin JA</searchLink>; Foundation Medicine Inc., Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Erlich+R%22">Erlich R</searchLink>; Foundation Medicine Inc., Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Fichtenholtz+A%22">Fichtenholtz A</searchLink>; Foundation Medicine Inc., Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Gowen+KA%22">Gowen KA</searchLink>; Foundation Medicine Inc., Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Greenbowe+J%22">Greenbowe J</searchLink>; Foundation Medicine Inc., Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Johnson+A%22">Johnson A</searchLink>; Foundation Medicine Inc., Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Khaira+D%22">Khaira D</searchLink>; Foundation Medicine Inc., Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22McMahon+C%22">McMahon C</searchLink>; Foundation Medicine Inc., Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Sanford+EM%22">Sanford EM</searchLink>; Foundation Medicine Inc., Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Roels+S%22">Roels S</searchLink>; Foundation Medicine Inc., Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22White+J%22">White J</searchLink>; Foundation Medicine Inc., Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Greshock+J%22">Greshock J</searchLink>; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Schlegel+R%22">Schlegel R</searchLink>; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Lipson+D%22">Lipson D</searchLink>; Foundation Medicine Inc., Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Yelensky+R%22">Yelensky R</searchLink>; Foundation Medicine Inc., Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Morosini+D%22">Morosini D</searchLink>; Foundation Medicine Inc., Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Ross+JS%22">Ross JS</searchLink>; Foundation Medicine Inc., Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Collisson+E%22">Collisson E</searchLink>; Division of Hematology and Oncology, Department of Medicine, University of California, San Francisco, San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Peters+M%22">Peters M</searchLink>; Novartis Pharma AG, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Stephens+PJ%22">Stephens PJ</searchLink>; Foundation Medicine Inc., Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Miller+VA%22">Miller VA</searchLink>; Foundation Medicine Inc., Cambridge, Massachusetts. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101561693%22">Cancer discovery</searchLink> [Cancer Discov] 2015 Aug; Vol. 5 (8), pp. 850-9. <i>Date of Electronic Publication: </i>2015 May 13. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Research Support, Non-U.S. Gov't – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+Cancer+Research%22">American Association for Cancer Research </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101561693 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2159-8290 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2221598274%22">21598274 </searchLink><i>NLM ISO Abbreviation: </i>Cancer Discov <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=25971938 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1158/2159-8290.CD-15-0285 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 850 Titles: – TitleFull: Activation of MET via diverse exon 14 splicing alterations occurs in multiple tumor types and confers clinical sensitivity to MET inhibitors. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Frampton GM – PersonEntity: Name: NameFull: Ali SM – PersonEntity: Name: NameFull: Rosenzweig M – PersonEntity: Name: NameFull: Chmielecki J – PersonEntity: Name: NameFull: Lu X – PersonEntity: Name: NameFull: Bauer TM – PersonEntity: Name: NameFull: Akimov M – PersonEntity: Name: NameFull: Bufill JA – PersonEntity: Name: NameFull: Lee C – PersonEntity: Name: NameFull: Jentz D – PersonEntity: Name: NameFull: Hoover R – PersonEntity: Name: NameFull: Ou SH – PersonEntity: Name: NameFull: Salgia R – PersonEntity: Name: NameFull: Brennan T – PersonEntity: Name: NameFull: Chalmers ZR – PersonEntity: Name: NameFull: Jaeger S – PersonEntity: Name: NameFull: Huang A – PersonEntity: Name: NameFull: Elvin JA – PersonEntity: Name: NameFull: Erlich R – PersonEntity: Name: NameFull: Fichtenholtz A – PersonEntity: Name: NameFull: Gowen KA – PersonEntity: Name: NameFull: Greenbowe J – PersonEntity: Name: NameFull: Johnson A – PersonEntity: Name: NameFull: Khaira D – PersonEntity: Name: NameFull: McMahon C – PersonEntity: Name: NameFull: Sanford EM – PersonEntity: Name: NameFull: Roels S – PersonEntity: Name: NameFull: White J – PersonEntity: Name: NameFull: Greshock J – PersonEntity: Name: NameFull: Schlegel R – PersonEntity: Name: NameFull: Lipson D – PersonEntity: Name: NameFull: Yelensky R – PersonEntity: Name: NameFull: Morosini D – PersonEntity: Name: NameFull: Ross JS – PersonEntity: Name: NameFull: Collisson E – PersonEntity: Name: NameFull: Peters M – PersonEntity: Name: NameFull: Stephens PJ – PersonEntity: Name: NameFull: Miller VA IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 08 Text: 2015 Aug Type: published Y: 2015 Identifiers: – Type: issn-electronic Value: 2159-8290 Numbering: – Type: volume Value: 5 – Type: issue Value: 8 Titles: – TitleFull: Cancer discovery Type: main |
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