View in EDS

Design of selective PI3Kα inhibitors starting from a promiscuous pan kinase scaffold.

Saved in:
Bibliographic Details
Title: Design of selective PI3Kα inhibitors starting from a promiscuous pan kinase scaffold.
Authors: Barlaam B; AstraZeneca, Oncology iMed, Alderley Park, Macclesfield, Cheshire SK10 4TG, United Kingdom. Electronic address: bernard.barlaam2@astrazeneca.com., Cosulich S; AstraZeneca, Oncology iMed, Alderley Park, Macclesfield, Cheshire SK10 4TG, United Kingdom., Fitzek M; AstraZeneca, Oncology iMed, Alderley Park, Macclesfield, Cheshire SK10 4TG, United Kingdom., Green S; AstraZeneca, Oncology iMed, Alderley Park, Macclesfield, Cheshire SK10 4TG, United Kingdom., Harris CS; AstraZeneca, Centre de Recherches, Z.I. La Pompelle, B.P. 1050, Chemin de Vrilly, 51689 Reims Cedex 2, France., Hudson K; AstraZeneca, Oncology iMed, Alderley Park, Macclesfield, Cheshire SK10 4TG, United Kingdom., Lambert-van der Brempt C; AstraZeneca, Centre de Recherches, Z.I. La Pompelle, B.P. 1050, Chemin de Vrilly, 51689 Reims Cedex 2, France., Ouvry G; AstraZeneca, Centre de Recherches, Z.I. La Pompelle, B.P. 1050, Chemin de Vrilly, 51689 Reims Cedex 2, France., Page K; AstraZeneca, Oncology iMed, Alderley Park, Macclesfield, Cheshire SK10 4TG, United Kingdom., Ruston L; AstraZeneca, Oncology iMed, Alderley Park, Macclesfield, Cheshire SK10 4TG, United Kingdom., Ward L; AstraZeneca, Oncology iMed, Alderley Park, Macclesfield, Cheshire SK10 4TG, United Kingdom., Delouvrié B; AstraZeneca, Centre de Recherches, Z.I. La Pompelle, B.P. 1050, Chemin de Vrilly, 51689 Reims Cedex 2, France.
Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2015 Jul 01; Vol. 25 (13), pp. 2679-85. Date of Electronic Publication: 2015 Apr 29.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 25980912
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Design of selective PI3Kα inhibitors starting from a promiscuous pan kinase scaffold.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Barlaam+B%22">Barlaam B</searchLink>; AstraZeneca, Oncology iMed, Alderley Park, Macclesfield, Cheshire SK10 4TG, United Kingdom. Electronic address: bernard.barlaam2@astrazeneca.com.<br /><searchLink fieldCode="AU" term="%22Cosulich+S%22">Cosulich S</searchLink>; AstraZeneca, Oncology iMed, Alderley Park, Macclesfield, Cheshire SK10 4TG, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Fitzek+M%22">Fitzek M</searchLink>; AstraZeneca, Oncology iMed, Alderley Park, Macclesfield, Cheshire SK10 4TG, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Green+S%22">Green S</searchLink>; AstraZeneca, Oncology iMed, Alderley Park, Macclesfield, Cheshire SK10 4TG, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Harris+CS%22">Harris CS</searchLink>; AstraZeneca, Centre de Recherches, Z.I. La Pompelle, B.P. 1050, Chemin de Vrilly, 51689 Reims Cedex 2, France.<br /><searchLink fieldCode="AU" term="%22Hudson+K%22">Hudson K</searchLink>; AstraZeneca, Oncology iMed, Alderley Park, Macclesfield, Cheshire SK10 4TG, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Lambert-van+der+Brempt+C%22">Lambert-van der Brempt C</searchLink>; AstraZeneca, Centre de Recherches, Z.I. La Pompelle, B.P. 1050, Chemin de Vrilly, 51689 Reims Cedex 2, France.<br /><searchLink fieldCode="AU" term="%22Ouvry+G%22">Ouvry G</searchLink>; AstraZeneca, Centre de Recherches, Z.I. La Pompelle, B.P. 1050, Chemin de Vrilly, 51689 Reims Cedex 2, France.<br /><searchLink fieldCode="AU" term="%22Page+K%22">Page K</searchLink>; AstraZeneca, Oncology iMed, Alderley Park, Macclesfield, Cheshire SK10 4TG, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Ruston+L%22">Ruston L</searchLink>; AstraZeneca, Oncology iMed, Alderley Park, Macclesfield, Cheshire SK10 4TG, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Ward+L%22">Ward L</searchLink>; AstraZeneca, Oncology iMed, Alderley Park, Macclesfield, Cheshire SK10 4TG, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Delouvrié+B%22">Delouvrié B</searchLink>; AstraZeneca, Centre de Recherches, Z.I. La Pompelle, B.P. 1050, Chemin de Vrilly, 51689 Reims Cedex 2, France.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%229107377%22">Bioorganic & medicinal chemistry letters</searchLink> [Bioorg Med Chem Lett] 2015 Jul 01; Vol. 25 (13), pp. 2679-85. <i>Date of Electronic Publication: </i>2015 Apr 29.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science+Ltd%22">Elsevier Science Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9107377 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1464-3405 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220960894X%22">0960894X </searchLink><i>NLM ISO Abbreviation: </i>Bioorg Med Chem Lett <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=25980912
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.bmcl.2015.04.084
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 2679
    Titles:
      – TitleFull: Design of selective PI3Kα inhibitors starting from a promiscuous pan kinase scaffold.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Barlaam B
      – PersonEntity:
          Name:
            NameFull: Cosulich S
      – PersonEntity:
          Name:
            NameFull: Fitzek M
      – PersonEntity:
          Name:
            NameFull: Green S
      – PersonEntity:
          Name:
            NameFull: Harris CS
      – PersonEntity:
          Name:
            NameFull: Hudson K
      – PersonEntity:
          Name:
            NameFull: Lambert-van der Brempt C
      – PersonEntity:
          Name:
            NameFull: Ouvry G
      – PersonEntity:
          Name:
            NameFull: Page K
      – PersonEntity:
          Name:
            NameFull: Ruston L
      – PersonEntity:
          Name:
            NameFull: Ward L
      – PersonEntity:
          Name:
            NameFull: Delouvrié B
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 07
              Text: 2015 Jul 01
              Type: published
              Y: 2015
          Identifiers:
            – Type: issn-electronic
              Value: 1464-3405
          Numbering:
            – Type: volume
              Value: 25
            – Type: issue
              Value: 13
          Titles:
            – TitleFull: Bioorganic & medicinal chemistry letters
              Type: main
ResultId 1