Increased stiffness is the major early abnormality in a pig model of severe aortic stenosis and predisposes to congestive heart failure in the absence of systolic dysfunction. - Ishikawa K; Aguero J; Oh JG; Hammoudi N; Fish LA; Leonardson L; Picatoste B; Santos-Gallego CG; Fish KM; Hajjar RJ (Journal of the American Heart Association, 2015)