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Crystal Structure of Antagonist Bound Human Lysophosphatidic Acid Receptor 1.

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Title: Crystal Structure of Antagonist Bound Human Lysophosphatidic Acid Receptor 1.
Authors: Chrencik JE; Department of Structural Discovery, Receptos, San Diego, CA 92121, USA., Roth CB; Department of Structural Discovery, Receptos, San Diego, CA 92121, USA., Terakado M; Medicinal Chemistry Research Laboratories, Ono Pharmaceutical Co., Ltd., Osaka 618-8585, Japan., Kurata H; Medicinal Chemistry Research Laboratories, Ono Pharmaceutical Co., Ltd., Osaka 618-8585, Japan., Omi R; Medicinal Chemistry Research Laboratories, Ono Pharmaceutical Co., Ltd., Osaka 618-8585, Japan., Kihara Y; Department of Molecular and Cellular Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA., Warshaviak D; Schrödinger Inc., 120 West 45th Street, New York, NY 10036, USA., Nakade S; Exploratory Research Laboratories, Ono Pharmaceutical Co., Ltd., Ibaraki 300-4247, Japan., Asmar-Rovira G; Department of Structural Discovery, Receptos, San Diego, CA 92121, USA., Mileni M; Department of Structural Discovery, Receptos, San Diego, CA 92121, USA., Mizuno H; Department of Molecular and Cellular Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA; Exploratory Research Laboratories, Ono Pharmaceutical Co., Ltd., Ibaraki 300-4247, Japan., Griffith MT; Department of Structural Discovery, Receptos, San Diego, CA 92121, USA., Rodgers C; Department of Structural Discovery, Receptos, San Diego, CA 92121, USA., Han GW; Departments of Biological Sciences and Chemistry, Bridge Institute, University of Southern California, Los Angeles, Los Angeles, CA 90089, USA., Velasquez J; Departments of Biological Sciences and Chemistry, Bridge Institute, University of Southern California, Los Angeles, Los Angeles, CA 90089, USA., Chun J; Department of Molecular and Cellular Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA., Stevens RC; Departments of Biological Sciences and Chemistry, Bridge Institute, University of Southern California, Los Angeles, Los Angeles, CA 90089, USA; iHuman Institute, ShanghaiTech University, 2F Building 6, 99 Haike Road, Pudong New District, Shanghai, 201210, China., Hanson MA; Department of Structural Discovery, Receptos, San Diego, CA 92121, USA. Electronic address: mhanson@gpcrconsortium.org.
Source: Cell [Cell] 2015 Jun 18; Vol. 161 (7), pp. 1633-43.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Crystal Structure of Antagonist Bound Human Lysophosphatidic Acid Receptor 1.
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  Data: <searchLink fieldCode="AU" term="%22Chrencik+JE%22">Chrencik JE</searchLink>; Department of Structural Discovery, Receptos, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Roth+CB%22">Roth CB</searchLink>; Department of Structural Discovery, Receptos, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Terakado+M%22">Terakado M</searchLink>; Medicinal Chemistry Research Laboratories, Ono Pharmaceutical Co., Ltd., Osaka 618-8585, Japan.<br /><searchLink fieldCode="AU" term="%22Kurata+H%22">Kurata H</searchLink>; Medicinal Chemistry Research Laboratories, Ono Pharmaceutical Co., Ltd., Osaka 618-8585, Japan.<br /><searchLink fieldCode="AU" term="%22Omi+R%22">Omi R</searchLink>; Medicinal Chemistry Research Laboratories, Ono Pharmaceutical Co., Ltd., Osaka 618-8585, Japan.<br /><searchLink fieldCode="AU" term="%22Kihara+Y%22">Kihara Y</searchLink>; Department of Molecular and Cellular Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Warshaviak+D%22">Warshaviak D</searchLink>; Schrödinger Inc., 120 West 45th Street, New York, NY 10036, USA.<br /><searchLink fieldCode="AU" term="%22Nakade+S%22">Nakade S</searchLink>; Exploratory Research Laboratories, Ono Pharmaceutical Co., Ltd., Ibaraki 300-4247, Japan.<br /><searchLink fieldCode="AU" term="%22Asmar-Rovira+G%22">Asmar-Rovira G</searchLink>; Department of Structural Discovery, Receptos, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Mileni+M%22">Mileni M</searchLink>; Department of Structural Discovery, Receptos, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Mizuno+H%22">Mizuno H</searchLink>; Department of Molecular and Cellular Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA; Exploratory Research Laboratories, Ono Pharmaceutical Co., Ltd., Ibaraki 300-4247, Japan.<br /><searchLink fieldCode="AU" term="%22Griffith+MT%22">Griffith MT</searchLink>; Department of Structural Discovery, Receptos, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Rodgers+C%22">Rodgers C</searchLink>; Department of Structural Discovery, Receptos, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Han+GW%22">Han GW</searchLink>; Departments of Biological Sciences and Chemistry, Bridge Institute, University of Southern California, Los Angeles, Los Angeles, CA 90089, USA.<br /><searchLink fieldCode="AU" term="%22Velasquez+J%22">Velasquez J</searchLink>; Departments of Biological Sciences and Chemistry, Bridge Institute, University of Southern California, Los Angeles, Los Angeles, CA 90089, USA.<br /><searchLink fieldCode="AU" term="%22Chun+J%22">Chun J</searchLink>; Department of Molecular and Cellular Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Stevens+RC%22">Stevens RC</searchLink>; Departments of Biological Sciences and Chemistry, Bridge Institute, University of Southern California, Los Angeles, Los Angeles, CA 90089, USA; iHuman Institute, ShanghaiTech University, 2F Building 6, 99 Haike Road, Pudong New District, Shanghai, 201210, China.<br /><searchLink fieldCode="AU" term="%22Hanson+MA%22">Hanson MA</searchLink>; Department of Structural Discovery, Receptos, San Diego, CA 92121, USA. Electronic address: mhanson@gpcrconsortium.org.
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