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Validation of a quantitative cerebrospinal fluid alpha-synuclein assay in a European-wide interlaboratory study.

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Title: Validation of a quantitative cerebrospinal fluid alpha-synuclein assay in a European-wide interlaboratory study.
Authors: Kruse N; Department of Neuropathology, University Medical Center, Göttingen, Germany. Electronic address: n.kruse@med.uni-goettingen.de., Persson S; Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital, Mölndal, Sweden., Alcolea D; Department of Neurology, Institut Investigacions Biomediques, Hospital de Sant Pau, Barcelona, Spain; Centro de Investigación Biomédica en Red en enfermedades Neurodegenerativas-CIBERNED, Madrid, Spain., Bahl JM; Department of Autoimmunology & Biomarkers, Statens Serum Institut, Copenhagen S, Denmark., Baldeiras I; Neurochemistry Laboratory, Department of Neurology, Faculty of Medicine, CHUC-Centro Hospitalar e Universitário de Coimbra, CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal., Capello E; Department of Neuroscience (DINOGMI), Clinical Neurology Unit, Genoa, Italy., Chiasserini D; Centre for Memory Disturbances and Alzheimer's Centre-Laboratory of Clinical Neurochemistry, Department of Medicine, Section of Neurology, University of Perugia, Perugia, Italy., Bocchio Chiavetto L; Neuropsychopharmacology Unit, IRCCS Cento S. Giovanni di Dio Fatebenefratelli, Brescia, Italy; Faculty of Psychology, eCampus University, Novedrate (Como), Italy., Emersic A; Department of Neurology, University Medical Centre, Ljubljana, Slovenia., Engelborghs S; Reference Centre for Biological Markers of Dementia (BIODEM), Institute Born-Bunge, University of Antwerp, Antwerp, Belgium., Eren E; Department of Neuroscience, Health Science Institute, Dokuz Eylül University, Izmir, Turkey., Fladby T; Department of Neurology, Akershus University Hospital, Lørenskog, Norway., Frisoni G; Laboratory of Alzheimer´s Neuroimaging and Epidemiology, IRCCS Centro S. Giovanni di Dio Fatebenefratelli, Brescia, Italy; Departments of Psychiatry and Internal Medicine, University Hospitals and University of Geneva, Geneva, Switzerland., García-Ayllón MS; Centro de Investigación Biomédica en Red en enfermedades Neurodegenerativas-CIBERNED, Madrid, Spain; Instituto de Neurociencias de Alicante, Universidad Miguel Hernández-CSIC, Sant Joan d´Alcant, Spain., Genc S; Department of Neuroscience, Health Science Institute, Dokuz Eylül University, Izmir, Turkey., Gkatzima O; 3rd Neurology Department, Aristotle University of Thessaloniki, Thessaloniki, Greece., Heegaard NH; Department of Autoimmunology & Biomarkers, Statens Serum Institut, Copenhagen S, Denmark; Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense C, Denmark., Janeiro AM; Genomed, Diagnósticos de Medicina Molecular, Instituto de Medicina Molecular, Edificio Egas Moniz, Lisbon, Portugal., Kováčech B; Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovakia., Kuiperij HB; Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands; Department of Laboratory Medicine, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands., Leitão MJ; Neurochemistry Laboratory, Department of Neurology, Faculty of Medicine, CHUC-Centro Hospitalar e Universitário de Coimbra, CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal., Lleó A; Department of Neurology, Institut Investigacions Biomediques, Hospital de Sant Pau, Barcelona, Spain; Centro de Investigación Biomédica en Red en enfermedades Neurodegenerativas-CIBERNED, Madrid, Spain., Martins M; Instituto de Medicina Molecular, Edificio Egas Moniz, Lisbon, Portugal; Instituto Gulbenkian de Ciência, Oeiras, Portugal., Matos M; Instituto de Medicina Molecular, Edificio Egas Moniz, Lisbon, Portugal., Mollergard HM; Department of Neurology, Akershus University Hospital, Lørenskog, Norway., Nobili F; Department of Neuroscience (DINOGMI), Clinical Neurology Unit, Genoa, Italy., Öhrfelt A; Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital, Mölndal, Sweden., Parnetti L; Centre for Memory Disturbances and Alzheimer's Centre-Laboratory of Clinical Neurochemistry, Department of Medicine, Section of Neurology, University of Perugia, Perugia, Italy., de Oliveira CR; Neurochemistry Laboratory, Department of Neurology, Faculty of Medicine, CHUC-Centro Hospitalar e Universitário de Coimbra, CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal., Rot U; Department of Neurology, University Medical Centre, Ljubljana, Slovenia., Sáez-Valero J; Centro de Investigación Biomédica en Red en enfermedades Neurodegenerativas-CIBERNED, Madrid, Spain; Instituto de Neurociencias de Alicante, Universidad Miguel Hernández-CSIC, Sant Joan d´Alcant, Spain., Struyfs H; Reference Centre for Biological Markers of Dementia (BIODEM), Institute Born-Bunge, University of Antwerp, Antwerp, Belgium., Tanassi JT; Department of Autoimmunology & Biomarkers, Statens Serum Institut, Copenhagen S, Denmark., Taylor P; BioLegend, Inc., Dedham, MA, USA., Tsolaki M; 3rd Neurology Department, Aristotle University of Thessaloniki, Thessaloniki, Greece., Vanmechelen E; ADx NeuroSciences NV, Gent, Belgium., Verbeek MM; Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands; Department of Laboratory Medicine, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands., Zilka N; Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovakia., Blennow K; Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital, Mölndal, Sweden., Zetterberg H; Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital, Mölndal, Sweden; Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK., Mollenhauer B; Department of Neuropathology, University Medical Center, Göttingen, Germany; Paracelsus-Elena-Klinik, Kassel, Germany; Department of Neurosurgery, University Medical Center, Göttingen, Germany.
Source: Neurobiology of aging [Neurobiol Aging] 2015 Sep; Vol. 36 (9), pp. 2587-96. Date of Electronic Publication: 2015 May 15.
Publication Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 8100437 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1558-1497 (Electronic) Linking ISSN: 01974580 NLM ISO Abbreviation: Neurobiol Aging Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Kruse+N%22">Kruse N</searchLink>; Department of Neuropathology, University Medical Center, Göttingen, Germany. Electronic address: n.kruse@med.uni-goettingen.de.<br /><searchLink fieldCode="AU" term="%22Persson+S%22">Persson S</searchLink>; Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital, Mölndal, Sweden.<br /><searchLink fieldCode="AU" term="%22Alcolea+D%22">Alcolea D</searchLink>; Department of Neurology, Institut Investigacions Biomediques, Hospital de Sant Pau, Barcelona, Spain; Centro de Investigación Biomédica en Red en enfermedades Neurodegenerativas-CIBERNED, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Bahl+JM%22">Bahl JM</searchLink>; Department of Autoimmunology & Biomarkers, Statens Serum Institut, Copenhagen S, Denmark.<br /><searchLink fieldCode="AU" term="%22Baldeiras+I%22">Baldeiras I</searchLink>; Neurochemistry Laboratory, Department of Neurology, Faculty of Medicine, CHUC-Centro Hospitalar e Universitário de Coimbra, CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.<br /><searchLink fieldCode="AU" term="%22Capello+E%22">Capello E</searchLink>; Department of Neuroscience (DINOGMI), Clinical Neurology Unit, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Chiasserini+D%22">Chiasserini D</searchLink>; Centre for Memory Disturbances and Alzheimer's Centre-Laboratory of Clinical Neurochemistry, Department of Medicine, Section of Neurology, University of Perugia, Perugia, Italy.<br /><searchLink fieldCode="AU" term="%22Bocchio+Chiavetto+L%22">Bocchio Chiavetto L</searchLink>; Neuropsychopharmacology Unit, IRCCS Cento S. 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Giovanni di Dio Fatebenefratelli, Brescia, Italy; Departments of Psychiatry and Internal Medicine, University Hospitals and University of Geneva, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22García-Ayllón+MS%22">García-Ayllón MS</searchLink>; Centro de Investigación Biomédica en Red en enfermedades Neurodegenerativas-CIBERNED, Madrid, Spain; Instituto de Neurociencias de Alicante, Universidad Miguel Hernández-CSIC, Sant Joan d´Alcant, Spain.<br /><searchLink fieldCode="AU" term="%22Genc+S%22">Genc S</searchLink>; Department of Neuroscience, Health Science Institute, Dokuz Eylül University, Izmir, Turkey.<br /><searchLink fieldCode="AU" term="%22Gkatzima+O%22">Gkatzima O</searchLink>; 3rd Neurology Department, Aristotle University of Thessaloniki, Thessaloniki, Greece.<br /><searchLink fieldCode="AU" term="%22Heegaard+NH%22">Heegaard NH</searchLink>; Department of Autoimmunology & Biomarkers, Statens Serum Institut, Copenhagen S, Denmark; Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense C, Denmark.<br /><searchLink fieldCode="AU" term="%22Janeiro+AM%22">Janeiro AM</searchLink>; Genomed, Diagnósticos de Medicina Molecular, Instituto de Medicina Molecular, Edificio Egas Moniz, Lisbon, Portugal.<br /><searchLink fieldCode="AU" term="%22Kováčech+B%22">Kováčech B</searchLink>; Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovakia.<br /><searchLink fieldCode="AU" term="%22Kuiperij+HB%22">Kuiperij HB</searchLink>; Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands; Department of Laboratory Medicine, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Leitão+MJ%22">Leitão MJ</searchLink>; Neurochemistry Laboratory, Department of Neurology, Faculty of Medicine, CHUC-Centro Hospitalar e Universitário de Coimbra, CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.<br /><searchLink fieldCode="AU" term="%22Lleó+A%22">Lleó A</searchLink>; 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Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital, Mölndal, Sweden.<br /><searchLink fieldCode="AU" term="%22Zetterberg+H%22">Zetterberg H</searchLink>; Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital, Mölndal, Sweden; Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22Mollenhauer+B%22">Mollenhauer B</searchLink>; Department of Neuropathology, University Medical Center, Göttingen, Germany; Paracelsus-Elena-Klinik, Kassel, Germany; Department of Neurosurgery, University Medical Center, Göttingen, Germany.
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