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Pre- and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection.

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Title: Pre- and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection.
Authors: Pascal KE; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591;, Coleman CM; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201;, Mujica AO; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591;, Kamat V; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591;, Badithe A; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591;, Fairhurst J; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591;, Hunt C; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591;, Strein J; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591;, Berrebi A; Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201., Sisk JM; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201;, Matthews KL; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201;, Babb R; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591;, Chen G; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591;, Lai KM; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591;, Huang TT; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591;, Olson W; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591;, Yancopoulos GD; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591; george@regeneron.com christos.kyratsous@regeneron.com., Stahl N; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591;, Frieman MB; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201;, Kyratsous CA; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591; george@regeneron.com christos.kyratsous@regeneron.com.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2015 Jul 14; Vol. 112 (28), pp. 8738-43. Date of Electronic Publication: 2015 Jun 29.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: Pre- and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection.
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  Data: <searchLink fieldCode="AU" term="%22Pascal+KE%22">Pascal KE</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591;<br /><searchLink fieldCode="AU" term="%22Coleman+CM%22">Coleman CM</searchLink>; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201;<br /><searchLink fieldCode="AU" term="%22Mujica+AO%22">Mujica AO</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591;<br /><searchLink fieldCode="AU" term="%22Kamat+V%22">Kamat V</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591;<br /><searchLink fieldCode="AU" term="%22Badithe+A%22">Badithe A</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591;<br /><searchLink fieldCode="AU" term="%22Fairhurst+J%22">Fairhurst J</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591;<br /><searchLink fieldCode="AU" term="%22Hunt+C%22">Hunt C</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591;<br /><searchLink fieldCode="AU" term="%22Strein+J%22">Strein J</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591;<br /><searchLink fieldCode="AU" term="%22Berrebi+A%22">Berrebi A</searchLink>; Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201.<br /><searchLink fieldCode="AU" term="%22Sisk+JM%22">Sisk JM</searchLink>; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201;<br /><searchLink fieldCode="AU" term="%22Matthews+KL%22">Matthews KL</searchLink>; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201;<br /><searchLink fieldCode="AU" term="%22Babb+R%22">Babb R</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591;<br /><searchLink fieldCode="AU" term="%22Chen+G%22">Chen G</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591;<br /><searchLink fieldCode="AU" term="%22Lai+KM%22">Lai KM</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591;<br /><searchLink fieldCode="AU" term="%22Huang+TT%22">Huang TT</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591;<br /><searchLink fieldCode="AU" term="%22Olson+W%22">Olson W</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591;<br /><searchLink fieldCode="AU" term="%22Yancopoulos+GD%22">Yancopoulos GD</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591; george@regeneron.com christos.kyratsous@regeneron.com.<br /><searchLink fieldCode="AU" term="%22Stahl+N%22">Stahl N</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591;<br /><searchLink fieldCode="AU" term="%22Frieman+MB%22">Frieman MB</searchLink>; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201;<br /><searchLink fieldCode="AU" term="%22Kyratsous+CA%22">Kyratsous CA</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591; george@regeneron.com christos.kyratsous@regeneron.com.
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  Data: <searchLink fieldCode="JN" term="%227505876%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink> [Proc Natl Acad Sci U S A] 2015 Jul 14; Vol. 112 (28), pp. 8738-43. <i>Date of Electronic Publication: </i>2015 Jun 29.
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