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Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk.

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Title: Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk.
Authors: Hu X; 1] Department of Medicine, Brigham and Women's Hospital, Division of Rheumatology, Immunology and Allergy, Boston, Massachusetts, USA. [2] Department of Medicine, Brigham and Women's Hospital, Division of Genetics, Harvard Medical School, Boston, Massachusetts, USA. [3] Partners Center for Personalized Genetic Medicine, Boston, Massachusetts, USA. [4] Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA. [5] Harvard-MIT Division of Health Sciences and Technology, Boston, Massachusetts, USA. [6] Division of Medical Sciences, Harvard Medical School, Boston, Massachusetts, USA., Deutsch AJ; 1] Department of Medicine, Brigham and Women's Hospital, Division of Rheumatology, Immunology and Allergy, Boston, Massachusetts, USA. [2] Department of Medicine, Brigham and Women's Hospital, Division of Genetics, Harvard Medical School, Boston, Massachusetts, USA. [3] Partners Center for Personalized Genetic Medicine, Boston, Massachusetts, USA. [4] Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA. [5] Harvard-MIT Division of Health Sciences and Technology, Boston, Massachusetts, USA., Lenz TL; 1] Department of Medicine, Brigham and Women's Hospital, Division of Genetics, Harvard Medical School, Boston, Massachusetts, USA. [2] Evolutionary Immunogenomics, Department of Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Plön, Germany., Onengut-Gumuscu S; Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA., Han B; 1] Department of Medicine, Brigham and Women's Hospital, Division of Genetics, Harvard Medical School, Boston, Massachusetts, USA. [2] Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA. [3] Asan Institute for Life Sciences, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea., Chen WM; Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA., Howson JM; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Todd JA; Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK., de Bakker PI; 1] Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands. [2] Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands., Rich SS; Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA., Raychaudhuri S; 1] Department of Medicine, Brigham and Women's Hospital, Division of Rheumatology, Immunology and Allergy, Boston, Massachusetts, USA. [2] Department of Medicine, Brigham and Women's Hospital, Division of Genetics, Harvard Medical School, Boston, Massachusetts, USA. [3] Partners Center for Personalized Genetic Medicine, Boston, Massachusetts, USA. [4] Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA. [5] Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK.
Source: Nature genetics [Nat Genet] 2015 Aug; Vol. 47 (8), pp. 898-905. Date of Electronic Publication: 2015 Jul 13.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
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  Data: Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk.
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  Data: <searchLink fieldCode="AU" term="%22Hu+X%22">Hu X</searchLink>; 1] Department of Medicine, Brigham and Women's Hospital, Division of Rheumatology, Immunology and Allergy, Boston, Massachusetts, USA. [2] Department of Medicine, Brigham and Women's Hospital, Division of Genetics, Harvard Medical School, Boston, Massachusetts, USA. [3] Partners Center for Personalized Genetic Medicine, Boston, Massachusetts, USA. [4] Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA. [5] Harvard-MIT Division of Health Sciences and Technology, Boston, Massachusetts, USA. [6] Division of Medical Sciences, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Deutsch+AJ%22">Deutsch AJ</searchLink>; 1] Department of Medicine, Brigham and Women's Hospital, Division of Rheumatology, Immunology and Allergy, Boston, Massachusetts, USA. [2] Department of Medicine, Brigham and Women's Hospital, Division of Genetics, Harvard Medical School, Boston, Massachusetts, USA. [3] Partners Center for Personalized Genetic Medicine, Boston, Massachusetts, USA. [4] Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA. [5] Harvard-MIT Division of Health Sciences and Technology, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Lenz+TL%22">Lenz TL</searchLink>; 1] Department of Medicine, Brigham and Women's Hospital, Division of Genetics, Harvard Medical School, Boston, Massachusetts, USA. [2] Evolutionary Immunogenomics, Department of Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Plön, Germany.<br /><searchLink fieldCode="AU" term="%22Onengut-Gumuscu+S%22">Onengut-Gumuscu S</searchLink>; Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA.<br /><searchLink fieldCode="AU" term="%22Han+B%22">Han B</searchLink>; 1] Department of Medicine, Brigham and Women's Hospital, Division of Genetics, Harvard Medical School, Boston, Massachusetts, USA. [2] Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA. [3] Asan Institute for Life Sciences, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Chen+WM%22">Chen WM</searchLink>; Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA.<br /><searchLink fieldCode="AU" term="%22Howson+JM%22">Howson JM</searchLink>; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Todd+JA%22">Todd JA</searchLink>; Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22de+Bakker+PI%22">de Bakker PI</searchLink>; 1] Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands. [2] Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Rich+SS%22">Rich SS</searchLink>; Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA.<br /><searchLink fieldCode="AU" term="%22Raychaudhuri+S%22">Raychaudhuri S</searchLink>; 1] Department of Medicine, Brigham and Women's Hospital, Division of Rheumatology, Immunology and Allergy, Boston, Massachusetts, USA. [2] Department of Medicine, Brigham and Women's Hospital, Division of Genetics, Harvard Medical School, Boston, Massachusetts, USA. [3] Partners Center for Personalized Genetic Medicine, Boston, Massachusetts, USA. [4] Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA. [5] Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK.
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