Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseases.
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| Title: | Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseases. |
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| Authors: | Lenz TL; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Division of Medical Sciences, Harvard Medical School, Boston, Massachusetts, USA.; Evolutionary Immunogenomics, Department of Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Ploen, Germany., Deutsch AJ; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Division of Medical Sciences, Harvard Medical School, Boston, Massachusetts, USA.; Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Partners Center for Personalized Genetic Medicine, Boston, Massachusetts, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.; Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Boston, Massachusetts, USA., Han B; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Division of Medical Sciences, Harvard Medical School, Boston, Massachusetts, USA.; Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Partners Center for Personalized Genetic Medicine, Boston, Massachusetts, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.; Asan Institute for Life Sciences, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea., Hu X; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Division of Medical Sciences, Harvard Medical School, Boston, Massachusetts, USA.; Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Partners Center for Personalized Genetic Medicine, Boston, Massachusetts, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.; Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Boston, Massachusetts, USA., Okada Y; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Division of Medical Sciences, Harvard Medical School, Boston, Massachusetts, USA.; Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Partners Center for Personalized Genetic Medicine, Boston, Massachusetts, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.; Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Eyre S; Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Sciences Centre, Manchester, UK.; National Institute for Health Research (NIHR) Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals National Health Service (NHS) Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, UK., Knapp M; Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany., Zhernakova A; Genetics Department, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands., Huizinga TW; Department of Rheumatology, Leiden University Medical Centre, Leiden, the Netherlands., Abecasis G; Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.; Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Becker J; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany., Boeckxstaens GE; Translational Research Center for Gastrointestinal Disorders, KU Leuven, Leuven, Belgium., Chen WM; Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA., Franke A; Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany., Gladman DD; Division of Rheumatology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.; Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Research Institute, University of Toronto, Toronto, Ontario, Canada.; Toronto Western Research Institute, University of Toronto, Toronto, Ontario, Canada., Gockel I; Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, Leipzig, Germany., Gutierrez-Achury J; Genetics Department, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands., Martin J; Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas, Granada, Spain., Nair RP; Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA., Nöthen MM; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany., Onengut-Gumuscu S; Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA., Rahman P; Department of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland and Labrador, Canada., Rantapää-Dahlqvist S; Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.; Department of Rheumatology, Umeå University, Umeå, Sweden., Stuart PE; Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA., Tsoi LC; Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.; Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., van Heel DA; Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Worthington J; Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Sciences Centre, Manchester, UK.; National Institute for Health Research (NIHR) Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals National Health Service (NHS) Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, UK., Wouters MM; Translational Research Center for Gastrointestinal Disorders, KU Leuven, Leuven, Belgium., Klareskog L; Rheumatology Unit, Department of Medicine, Karolinska Institutet and Karolinska University Hospital Solna, Stockholm, Sweden., Elder JT; Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA.; Ann Arbor Veterans Affairs Hospital, Ann Arbor, Michigan, USA., Gregersen PK; Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System, Manhasset, New York, USA., Schumacher J; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany., Rich SS; Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA., Wijmenga C; Genetics Department, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands., Sunyaev SR; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Division of Medical Sciences, Harvard Medical School, Boston, Massachusetts, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., de Bakker PI; Department of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands.; Department of Epidemiology, University Medical Center Utrecht, Utrecht, the Netherlands., Raychaudhuri S; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Division of Medical Sciences, Harvard Medical School, Boston, Massachusetts, USA.; Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Partners Center for Personalized Genetic Medicine, Boston, Massachusetts, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.; Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Sciences Centre, Manchester, UK.; Rheumatology Unit, Department of Medicine, Karolinska Institutet and Karolinska University Hospital Solna, Stockholm, Sweden. |
| Source: | Nature genetics [Nat Genet] 2015 Sep; Vol. 47 (9), pp. 1085-90. Date of Electronic Publication: 2015 Aug 10. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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