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Characterization of 2,4-Diamino-6-oxo-1,6-dihydropyrimidin-5-yl Ureido Based Inhibitors of Trypanosoma brucei FolD and Testing for Antiparasitic Activity.

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Title: Characterization of 2,4-Diamino-6-oxo-1,6-dihydropyrimidin-5-yl Ureido Based Inhibitors of Trypanosoma brucei FolD and Testing for Antiparasitic Activity.
Authors: Eadsforth TC; Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee , Dow Street, Dundee DD1 5EH, U.K., Pinto A; Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano , Via Mangiagalli 25, 20133 Milano, Italy., Luciani R; Department of Life Science, University of Modena and Reggio Emilia , Via Campi 103, 41125, Modena, Italy., Tamborini L; Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano , Via Mangiagalli 25, 20133 Milano, Italy., Cullia G; Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano , Via Mangiagalli 25, 20133 Milano, Italy., De Micheli C; Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano , Via Mangiagalli 25, 20133 Milano, Italy., Marinelli L; Dipartimento di Farmacia, Università degli Studi di Napoli 'Federico II' , Via Montesano 49, 80131 Napoli, Italy., Cosconati S; DiSTABiF, Seconda Università di Napoli , Via Vivaldi 43, 81100 Caserta, Italy., Novellino E; Dipartimento di Farmacia, Università degli Studi di Napoli 'Federico II' , Via Montesano 49, 80131 Napoli, Italy., Lo Presti L; Dipartimento di Chimica, Università degli Studi di Milano , Via Golgi 19, 20133 Milano, Italy., Cordeiro da Silva A; Instituto de Investigação e Inovação em Saúde, Instituto de Biologia Molecular e Cellular da Universidade do Porto, Departamento de Ciências Biológicas, Universidade do Porto , Porto, Portugal., Conti P; Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano , Via Mangiagalli 25, 20133 Milano, Italy., Hunter WN; Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee , Dow Street, Dundee DD1 5EH, U.K., Costi MP; Department of Life Science, University of Modena and Reggio Emilia , Via Campi 103, 41125, Modena, Italy.
Source: Journal of medicinal chemistry [J Med Chem] 2015 Oct 22; Vol. 58 (20), pp. 7938-48. Date of Electronic Publication: 2015 Sep 16.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Characterization of 2,4-Diamino-6-oxo-1,6-dihydropyrimidin-5-yl Ureido Based Inhibitors of Trypanosoma brucei FolD and Testing for Antiparasitic Activity.
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  Data: <searchLink fieldCode="AU" term="%22Eadsforth+TC%22">Eadsforth TC</searchLink>; Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee , Dow Street, Dundee DD1 5EH, U.K.<br /><searchLink fieldCode="AU" term="%22Pinto+A%22">Pinto A</searchLink>; Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano , Via Mangiagalli 25, 20133 Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Luciani+R%22">Luciani R</searchLink>; Department of Life Science, University of Modena and Reggio Emilia , Via Campi 103, 41125, Modena, Italy.<br /><searchLink fieldCode="AU" term="%22Tamborini+L%22">Tamborini L</searchLink>; Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano , Via Mangiagalli 25, 20133 Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Cullia+G%22">Cullia G</searchLink>; Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano , Via Mangiagalli 25, 20133 Milano, Italy.<br /><searchLink fieldCode="AU" term="%22De+Micheli+C%22">De Micheli C</searchLink>; Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano , Via Mangiagalli 25, 20133 Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Marinelli+L%22">Marinelli L</searchLink>; Dipartimento di Farmacia, Università degli Studi di Napoli 'Federico II' , Via Montesano 49, 80131 Napoli, Italy.<br /><searchLink fieldCode="AU" term="%22Cosconati+S%22">Cosconati S</searchLink>; DiSTABiF, Seconda Università di Napoli , Via Vivaldi 43, 81100 Caserta, Italy.<br /><searchLink fieldCode="AU" term="%22Novellino+E%22">Novellino E</searchLink>; Dipartimento di Farmacia, Università degli Studi di Napoli 'Federico II' , Via Montesano 49, 80131 Napoli, Italy.<br /><searchLink fieldCode="AU" term="%22Lo+Presti+L%22">Lo Presti L</searchLink>; Dipartimento di Chimica, Università degli Studi di Milano , Via Golgi 19, 20133 Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Cordeiro+da+Silva+A%22">Cordeiro da Silva A</searchLink>; Instituto de Investigação e Inovação em Saúde, Instituto de Biologia Molecular e Cellular da Universidade do Porto, Departamento de Ciências Biológicas, Universidade do Porto , Porto, Portugal.<br /><searchLink fieldCode="AU" term="%22Conti+P%22">Conti P</searchLink>; Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano , Via Mangiagalli 25, 20133 Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Hunter+WN%22">Hunter WN</searchLink>; Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee , Dow Street, Dundee DD1 5EH, U.K.<br /><searchLink fieldCode="AU" term="%22Costi+MP%22">Costi MP</searchLink>; Department of Life Science, University of Modena and Reggio Emilia , Via Campi 103, 41125, Modena, Italy.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2015 Oct 22; Vol. 58 (20), pp. 7938-48. <i>Date of Electronic Publication: </i>2015 Sep 16.
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