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The E3 ligase RNF43 inhibits Wnt signaling downstream of mutated β-catenin by sequestering TCF4 to the nuclear membrane.

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Title: The E3 ligase RNF43 inhibits Wnt signaling downstream of mutated β-catenin by sequestering TCF4 to the nuclear membrane.
Authors: Loregger A; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene, Technische Universität München, Munich 81675, Germany., Grandl M; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene, Technische Universität München, Munich 81675, Germany., Mejías-Luque R; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene, Technische Universität München, Munich 81675, Germany., Allgäuer M; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene, Technische Universität München, Munich 81675, Germany. Medical Department II, Technische Universität München, Munich 81675, Germany., Degenhart K; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene, Technische Universität München, Munich 81675, Germany., Haselmann V; Institute for Clinical Chemistry, University Medical Centre Mannheim, Mannheim 68167, Germany., Oikonomou C; Division of Molecular Biology and Genetics, Biomedical Sciences Research Center 'Alexander Fleming,' Vari 16672, Greece., Hatzis P; Division of Molecular Biology and Genetics, Biomedical Sciences Research Center 'Alexander Fleming,' Vari 16672, Greece., Janssen KP; Department of Surgery, Technische Universität München, Munich 81675, Germany., Nitsche U; Department of Surgery, Technische Universität München, Munich 81675, Germany., Gradl D; Zoologisches Institut II, Karlsruhe Institute of Technology, Karlsruhe 76131, Germany., van den Broek O; Hubrecht Institute, Utrecht 3508, the Netherlands., Destree O; Hubrecht Institute, Utrecht 3508, the Netherlands., Ulm K; Institute of Medical Statistics and Epidemiology, Technische Universität München, Munich 81675, Germany., Neumaier M; Institute for Clinical Chemistry, University Medical Centre Mannheim, Mannheim 68167, Germany., Kalali B; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene, Technische Universität München, Munich 81675, Germany., Jung A; Institute of Pathology, University of Munich, Munich 80337, Germany., Varela I; Instituto de Biomedicina y Biotecnología de Cantabria, Santander 39011, Spain., Schmid RM; Medical Department II, Technische Universität München, Munich 81675, Germany., Rad R; Medical Department II, Technische Universität München, Munich 81675, Germany., Busch DH; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene, Technische Universität München, Munich 81675, Germany., Gerhard M; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene, Technische Universität München, Munich 81675, Germany. markus.gerhard@tum.de.
Source: Science signaling [Sci Signal] 2015 Sep 08; Vol. 8 (393), pp. ra90. Date of Electronic Publication: 2015 Sep 08.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101465400 Publication Model: Electronic Cited Medium: Internet ISSN: 1937-9145 (Electronic) Linking ISSN: 19450877 NLM ISO Abbreviation: Sci Signal Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The E3 ligase RNF43 inhibits Wnt signaling downstream of mutated β-catenin by sequestering TCF4 to the nuclear membrane.
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  Data: <searchLink fieldCode="AU" term="%22Loregger+A%22">Loregger A</searchLink>; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene, Technische Universität München, Munich 81675, Germany.<br /><searchLink fieldCode="AU" term="%22Grandl+M%22">Grandl M</searchLink>; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene, Technische Universität München, Munich 81675, Germany.<br /><searchLink fieldCode="AU" term="%22Mejías-Luque+R%22">Mejías-Luque R</searchLink>; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene, Technische Universität München, Munich 81675, Germany.<br /><searchLink fieldCode="AU" term="%22Allgäuer+M%22">Allgäuer M</searchLink>; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene, Technische Universität München, Munich 81675, Germany. Medical Department II, Technische Universität München, Munich 81675, Germany.<br /><searchLink fieldCode="AU" term="%22Degenhart+K%22">Degenhart K</searchLink>; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene, Technische Universität München, Munich 81675, Germany.<br /><searchLink fieldCode="AU" term="%22Haselmann+V%22">Haselmann V</searchLink>; Institute for Clinical Chemistry, University Medical Centre Mannheim, Mannheim 68167, Germany.<br /><searchLink fieldCode="AU" term="%22Oikonomou+C%22">Oikonomou C</searchLink>; Division of Molecular Biology and Genetics, Biomedical Sciences Research Center 'Alexander Fleming,' Vari 16672, Greece.<br /><searchLink fieldCode="AU" term="%22Hatzis+P%22">Hatzis P</searchLink>; Division of Molecular Biology and Genetics, Biomedical Sciences Research Center 'Alexander Fleming,' Vari 16672, Greece.<br /><searchLink fieldCode="AU" term="%22Janssen+KP%22">Janssen KP</searchLink>; Department of Surgery, Technische Universität München, Munich 81675, Germany.<br /><searchLink fieldCode="AU" term="%22Nitsche+U%22">Nitsche U</searchLink>; Department of Surgery, Technische Universität München, Munich 81675, Germany.<br /><searchLink fieldCode="AU" term="%22Gradl+D%22">Gradl D</searchLink>; Zoologisches Institut II, Karlsruhe Institute of Technology, Karlsruhe 76131, Germany.<br /><searchLink fieldCode="AU" term="%22van+den+Broek+O%22">van den Broek O</searchLink>; Hubrecht Institute, Utrecht 3508, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Destree+O%22">Destree O</searchLink>; Hubrecht Institute, Utrecht 3508, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Ulm+K%22">Ulm K</searchLink>; Institute of Medical Statistics and Epidemiology, Technische Universität München, Munich 81675, Germany.<br /><searchLink fieldCode="AU" term="%22Neumaier+M%22">Neumaier M</searchLink>; Institute for Clinical Chemistry, University Medical Centre Mannheim, Mannheim 68167, Germany.<br /><searchLink fieldCode="AU" term="%22Kalali+B%22">Kalali B</searchLink>; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene, Technische Universität München, Munich 81675, Germany.<br /><searchLink fieldCode="AU" term="%22Jung+A%22">Jung A</searchLink>; Institute of Pathology, University of Munich, Munich 80337, Germany.<br /><searchLink fieldCode="AU" term="%22Varela+I%22">Varela I</searchLink>; Instituto de Biomedicina y Biotecnología de Cantabria, Santander 39011, Spain.<br /><searchLink fieldCode="AU" term="%22Schmid+RM%22">Schmid RM</searchLink>; Medical Department II, Technische Universität München, Munich 81675, Germany.<br /><searchLink fieldCode="AU" term="%22Rad+R%22">Rad R</searchLink>; Medical Department II, Technische Universität München, Munich 81675, Germany.<br /><searchLink fieldCode="AU" term="%22Busch+DH%22">Busch DH</searchLink>; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene, Technische Universität München, Munich 81675, Germany.<br /><searchLink fieldCode="AU" term="%22Gerhard+M%22">Gerhard M</searchLink>; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene, Technische Universität München, Munich 81675, Germany. markus.gerhard@tum.de.
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