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NF2 Loss Promotes Oncogenic RAS-Induced Thyroid Cancers via YAP-Dependent Transactivation of RAS Proteins and Sensitizes Them to MEK Inhibition.

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Title: NF2 Loss Promotes Oncogenic RAS-Induced Thyroid Cancers via YAP-Dependent Transactivation of RAS Proteins and Sensitizes Them to MEK Inhibition.
Authors: Garcia-Rendueles ME; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York., Ricarte-Filho JC; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York., Untch BR; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York. Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York., Landa I; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York., Knauf JA; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York. Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York., Voza F; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York., Smith VE; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York., Ganly I; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York., Taylor BS; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York. Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York., Persaud Y; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York., Oler G; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York., Fang Y; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York., Jhanwar SC; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York., Viale A; Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York., Heguy A; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York., Huberman KH; Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York., Giancotti F; Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York. Department of Medicine, Weill Cornell Medical College, New York, New York., Ghossein R; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York., Fagin JA; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York. Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York. Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York. Department of Medicine, Weill Cornell Medical College, New York, New York. faginj@mskcc.org.
Source: Cancer discovery [Cancer Discov] 2015 Nov; Vol. 5 (11), pp. 1178-93. Date of Electronic Publication: 2015 Sep 10.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: NF2 Loss Promotes Oncogenic RAS-Induced Thyroid Cancers via YAP-Dependent Transactivation of RAS Proteins and Sensitizes Them to MEK Inhibition.
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