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Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase.

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Title: Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase.
Authors: Kung DW; Worldwide Medicinal Chemistry, Groton, CT 06340, United States. Electronic address: daniel.w.kung@pfizer.com., Griffith DA; Worldwide Medicinal Chemistry, Cambridge, MA 02139, United States. Electronic address: david.a.griffith@pfizer.com., Esler WP; Cardiovascular, Metabolic and Endocrine Diseases Research Unit, Cambridge, MA 02139, United States., Vajdos FF; Structural Biology, Groton, CT 06340, United States., Mathiowetz AM; Worldwide Medicinal Chemistry, Cambridge, MA 02139, United States., Doran SD; Pharmacokinetics, Dynamics and Metabolism, Groton, CT 06340, United States., Amor PA; Cardiovascular, Metabolic and Endocrine Diseases Research Unit, Cambridge, MA 02139, United States., Bagley SW; Worldwide Medicinal Chemistry, Groton, CT 06340, United States., Banks T; Worldwide Medicinal Chemistry, Groton, CT 06340, United States., Cabral S; Worldwide Medicinal Chemistry, Groton, CT 06340, United States., Ford K; Primary Pharmacology Group, Groton, CT 06340, United States., Garcia-Irizarry CN; Worldwide Medicinal Chemistry, Groton, CT 06340, United States., Landis MS; Pharmaceutical Sciences Research Formulations, Pfizer Worldwide Research and Development, Cambridge, MA 02139, United States., Loomis K; Cardiovascular, Metabolic and Endocrine Diseases Research Unit, Groton, CT 06340, United States., McPherson K; Cardiovascular, Metabolic and Endocrine Diseases Research Unit, Groton, CT 06340, United States., Niosi M; Pharmacokinetics, Dynamics and Metabolism, Groton, CT 06340, United States., Rockwell KL; Primary Pharmacology Group, Groton, CT 06340, United States., Rose C; Worldwide Medicinal Chemistry, Groton, CT 06340, United States., Smith AC; Worldwide Medicinal Chemistry, Groton, CT 06340, United States., Southers JA; Worldwide Medicinal Chemistry, Groton, CT 06340, United States., Tapley S; Cardiovascular, Metabolic and Endocrine Diseases Research Unit, Groton, CT 06340, United States., Tu M; Worldwide Medicinal Chemistry, Cambridge, MA 02139, United States., Valentine JJ; Primary Pharmacology Group, Groton, CT 06340, United States.
Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2015 Nov 15; Vol. 25 (22), pp. 5352-6. Date of Electronic Publication: 2015 Sep 15.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase.
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  Data: <searchLink fieldCode="AU" term="%22Kung+DW%22">Kung DW</searchLink>; Worldwide Medicinal Chemistry, Groton, CT 06340, United States. Electronic address: daniel.w.kung@pfizer.com.<br /><searchLink fieldCode="AU" term="%22Griffith+DA%22">Griffith DA</searchLink>; Worldwide Medicinal Chemistry, Cambridge, MA 02139, United States. Electronic address: david.a.griffith@pfizer.com.<br /><searchLink fieldCode="AU" term="%22Esler+WP%22">Esler WP</searchLink>; Cardiovascular, Metabolic and Endocrine Diseases Research Unit, Cambridge, MA 02139, United States.<br /><searchLink fieldCode="AU" term="%22Vajdos+FF%22">Vajdos FF</searchLink>; Structural Biology, Groton, CT 06340, United States.<br /><searchLink fieldCode="AU" term="%22Mathiowetz+AM%22">Mathiowetz AM</searchLink>; Worldwide Medicinal Chemistry, Cambridge, MA 02139, United States.<br /><searchLink fieldCode="AU" term="%22Doran+SD%22">Doran SD</searchLink>; Pharmacokinetics, Dynamics and Metabolism, Groton, CT 06340, United States.<br /><searchLink fieldCode="AU" term="%22Amor+PA%22">Amor PA</searchLink>; Cardiovascular, Metabolic and Endocrine Diseases Research Unit, Cambridge, MA 02139, United States.<br /><searchLink fieldCode="AU" term="%22Bagley+SW%22">Bagley SW</searchLink>; Worldwide Medicinal Chemistry, Groton, CT 06340, United States.<br /><searchLink fieldCode="AU" term="%22Banks+T%22">Banks T</searchLink>; Worldwide Medicinal Chemistry, Groton, CT 06340, United States.<br /><searchLink fieldCode="AU" term="%22Cabral+S%22">Cabral S</searchLink>; Worldwide Medicinal Chemistry, Groton, CT 06340, United States.<br /><searchLink fieldCode="AU" term="%22Ford+K%22">Ford K</searchLink>; Primary Pharmacology Group, Groton, CT 06340, United States.<br /><searchLink fieldCode="AU" term="%22Garcia-Irizarry+CN%22">Garcia-Irizarry CN</searchLink>; Worldwide Medicinal Chemistry, Groton, CT 06340, United States.<br /><searchLink fieldCode="AU" term="%22Landis+MS%22">Landis MS</searchLink>; Pharmaceutical Sciences Research Formulations, Pfizer Worldwide Research and Development, Cambridge, MA 02139, United States.<br /><searchLink fieldCode="AU" term="%22Loomis+K%22">Loomis K</searchLink>; Cardiovascular, Metabolic and Endocrine Diseases Research Unit, Groton, CT 06340, United States.<br /><searchLink fieldCode="AU" term="%22McPherson+K%22">McPherson K</searchLink>; Cardiovascular, Metabolic and Endocrine Diseases Research Unit, Groton, CT 06340, United States.<br /><searchLink fieldCode="AU" term="%22Niosi+M%22">Niosi M</searchLink>; Pharmacokinetics, Dynamics and Metabolism, Groton, CT 06340, United States.<br /><searchLink fieldCode="AU" term="%22Rockwell+KL%22">Rockwell KL</searchLink>; Primary Pharmacology Group, Groton, CT 06340, United States.<br /><searchLink fieldCode="AU" term="%22Rose+C%22">Rose C</searchLink>; Worldwide Medicinal Chemistry, Groton, CT 06340, United States.<br /><searchLink fieldCode="AU" term="%22Smith+AC%22">Smith AC</searchLink>; Worldwide Medicinal Chemistry, Groton, CT 06340, United States.<br /><searchLink fieldCode="AU" term="%22Southers+JA%22">Southers JA</searchLink>; Worldwide Medicinal Chemistry, Groton, CT 06340, United States.<br /><searchLink fieldCode="AU" term="%22Tapley+S%22">Tapley S</searchLink>; Cardiovascular, Metabolic and Endocrine Diseases Research Unit, Groton, CT 06340, United States.<br /><searchLink fieldCode="AU" term="%22Tu+M%22">Tu M</searchLink>; Worldwide Medicinal Chemistry, Cambridge, MA 02139, United States.<br /><searchLink fieldCode="AU" term="%22Valentine+JJ%22">Valentine JJ</searchLink>; Primary Pharmacology Group, Groton, CT 06340, United States.
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  Data: <searchLink fieldCode="JN" term="%229107377%22">Bioorganic & medicinal chemistry letters</searchLink> [Bioorg Med Chem Lett] 2015 Nov 15; Vol. 25 (22), pp. 5352-6. <i>Date of Electronic Publication: </i>2015 Sep 15.
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