Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase.
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| Title: | Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase. |
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| Authors: | Kung DW; Worldwide Medicinal Chemistry, Groton, CT 06340, United States. Electronic address: daniel.w.kung@pfizer.com., Griffith DA; Worldwide Medicinal Chemistry, Cambridge, MA 02139, United States. Electronic address: david.a.griffith@pfizer.com., Esler WP; Cardiovascular, Metabolic and Endocrine Diseases Research Unit, Cambridge, MA 02139, United States., Vajdos FF; Structural Biology, Groton, CT 06340, United States., Mathiowetz AM; Worldwide Medicinal Chemistry, Cambridge, MA 02139, United States., Doran SD; Pharmacokinetics, Dynamics and Metabolism, Groton, CT 06340, United States., Amor PA; Cardiovascular, Metabolic and Endocrine Diseases Research Unit, Cambridge, MA 02139, United States., Bagley SW; Worldwide Medicinal Chemistry, Groton, CT 06340, United States., Banks T; Worldwide Medicinal Chemistry, Groton, CT 06340, United States., Cabral S; Worldwide Medicinal Chemistry, Groton, CT 06340, United States., Ford K; Primary Pharmacology Group, Groton, CT 06340, United States., Garcia-Irizarry CN; Worldwide Medicinal Chemistry, Groton, CT 06340, United States., Landis MS; Pharmaceutical Sciences Research Formulations, Pfizer Worldwide Research and Development, Cambridge, MA 02139, United States., Loomis K; Cardiovascular, Metabolic and Endocrine Diseases Research Unit, Groton, CT 06340, United States., McPherson K; Cardiovascular, Metabolic and Endocrine Diseases Research Unit, Groton, CT 06340, United States., Niosi M; Pharmacokinetics, Dynamics and Metabolism, Groton, CT 06340, United States., Rockwell KL; Primary Pharmacology Group, Groton, CT 06340, United States., Rose C; Worldwide Medicinal Chemistry, Groton, CT 06340, United States., Smith AC; Worldwide Medicinal Chemistry, Groton, CT 06340, United States., Southers JA; Worldwide Medicinal Chemistry, Groton, CT 06340, United States., Tapley S; Cardiovascular, Metabolic and Endocrine Diseases Research Unit, Groton, CT 06340, United States., Tu M; Worldwide Medicinal Chemistry, Cambridge, MA 02139, United States., Valentine JJ; Primary Pharmacology Group, Groton, CT 06340, United States. |
| Source: | Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2015 Nov 15; Vol. 25 (22), pp. 5352-6. Date of Electronic Publication: 2015 Sep 15. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. |
| Journal Info: | Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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