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Discovery of an L-alanine ester prodrug of the Hsp90 inhibitor, MPC-3100.

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Title: Discovery of an L-alanine ester prodrug of the Hsp90 inhibitor, MPC-3100.
Authors: Kim SH; Orthobond Corporation, 675 U.S. 1, North Brunswick, NJ 08902, USA. Electronic address: seho.kimkim@gmail.com., Tangallapally R; St Jude Children's Research Hospital, Department of Chemical Biology, 262 Danny Thomas Place, Memphis, TN 38105, USA., Kim IC; New Hope Baptist Church, 149 Highland Ave., East Lansing, MI 48823, USA., Trovato R; Jacobs Engineering, 155 N, 400 W., Suite 550, Salt Lake City, UT 84103, USA., Parker D; AvidXchange, 6415 South, 3000 East, Suite 150, Salt Lake City, UT 84121, USA., Patton JS; Arup Laboratories, 500 Chipeta Way, Salt Lake City, UT 84108, USA., Reeves L; Genysis Labs, 391 Orange St, Salt Lake City, UT 84104, USA., Bradford C; Sera Prognostics, 2749 East Parleys Way, Suite 200, Salt Lake City, UT 84109, USA., Wettstein D; MediProPharma, 419 Wakara Way, #207B, Salt Lake City, UT 84108, USA., Baichwal V; Core Diagnostics, 2458 Embarcadero Way, Palo Alto, CA 94303, USA., Papac D; Navigen, 383 Colorow Dr, Salt Lake City, UT 84108, USA., Bajji A; VioGen Biosciences, 1290 West, 2320 South, Suite E, Salt Lake City, UT 84119, USA., Carlson R; Karyopharm Therapeutics, 85 Wells Ave., 2nd Floor, Newton, MA 02459, USA., Yager KM; Myriad Genetic Laboratories, 320 Wakara Way, Salt Lake City, UT 84108, USA. Electronic address: kraig.yager@gmail.com.
Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2015 Nov 15; Vol. 25 (22), pp. 5254-7. Date of Electronic Publication: 2015 Sep 28.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Discovery of an L-alanine ester prodrug of the Hsp90 inhibitor, MPC-3100.
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  Data: <searchLink fieldCode="AU" term="%22Kim+SH%22">Kim SH</searchLink>; Orthobond Corporation, 675 U.S. 1, North Brunswick, NJ 08902, USA. Electronic address: seho.kimkim@gmail.com.<br /><searchLink fieldCode="AU" term="%22Tangallapally+R%22">Tangallapally R</searchLink>; St Jude Children's Research Hospital, Department of Chemical Biology, 262 Danny Thomas Place, Memphis, TN 38105, USA.<br /><searchLink fieldCode="AU" term="%22Kim+IC%22">Kim IC</searchLink>; New Hope Baptist Church, 149 Highland Ave., East Lansing, MI 48823, USA.<br /><searchLink fieldCode="AU" term="%22Trovato+R%22">Trovato R</searchLink>; Jacobs Engineering, 155 N, 400 W., Suite 550, Salt Lake City, UT 84103, USA.<br /><searchLink fieldCode="AU" term="%22Parker+D%22">Parker D</searchLink>; AvidXchange, 6415 South, 3000 East, Suite 150, Salt Lake City, UT 84121, USA.<br /><searchLink fieldCode="AU" term="%22Patton+JS%22">Patton JS</searchLink>; Arup Laboratories, 500 Chipeta Way, Salt Lake City, UT 84108, USA.<br /><searchLink fieldCode="AU" term="%22Reeves+L%22">Reeves L</searchLink>; Genysis Labs, 391 Orange St, Salt Lake City, UT 84104, USA.<br /><searchLink fieldCode="AU" term="%22Bradford+C%22">Bradford C</searchLink>; Sera Prognostics, 2749 East Parleys Way, Suite 200, Salt Lake City, UT 84109, USA.<br /><searchLink fieldCode="AU" term="%22Wettstein+D%22">Wettstein D</searchLink>; MediProPharma, 419 Wakara Way, #207B, Salt Lake City, UT 84108, USA.<br /><searchLink fieldCode="AU" term="%22Baichwal+V%22">Baichwal V</searchLink>; Core Diagnostics, 2458 Embarcadero Way, Palo Alto, CA 94303, USA.<br /><searchLink fieldCode="AU" term="%22Papac+D%22">Papac D</searchLink>; Navigen, 383 Colorow Dr, Salt Lake City, UT 84108, USA.<br /><searchLink fieldCode="AU" term="%22Bajji+A%22">Bajji A</searchLink>; VioGen Biosciences, 1290 West, 2320 South, Suite E, Salt Lake City, UT 84119, USA.<br /><searchLink fieldCode="AU" term="%22Carlson+R%22">Carlson R</searchLink>; Karyopharm Therapeutics, 85 Wells Ave., 2nd Floor, Newton, MA 02459, USA.<br /><searchLink fieldCode="AU" term="%22Yager+KM%22">Yager KM</searchLink>; Myriad Genetic Laboratories, 320 Wakara Way, Salt Lake City, UT 84108, USA. Electronic address: kraig.yager@gmail.com.
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  Data: <searchLink fieldCode="JN" term="%229107377%22">Bioorganic & medicinal chemistry letters</searchLink> [Bioorg Med Chem Lett] 2015 Nov 15; Vol. 25 (22), pp. 5254-7. <i>Date of Electronic Publication: </i>2015 Sep 28.
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              Text: 2015 Nov 15
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