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Dinaciclib, a Cyclin-Dependent Kinase Inhibitor Promotes Proteasomal Degradation of Mcl-1 and Enhances ABT-737-Mediated Cell Death in Malignant Human Glioma Cell Lines.

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Title: Dinaciclib, a Cyclin-Dependent Kinase Inhibitor Promotes Proteasomal Degradation of Mcl-1 and Enhances ABT-737-Mediated Cell Death in Malignant Human Glioma Cell Lines.
Authors: Jane EP; Department of Neurologic Surgery, Children's Hospital of Pittsburgh (E.P.J., D.R.P., I.F.P.), University of Pittsburgh, School of Medicine (E.P.J., D.R.P., J.M.C., P.A.S., T.R., I.F.P), and University of Pittsburgh Brain Tumor Center (D.R.P., I.F.P.), Pittsburgh, Pennsylvania., Premkumar DR; Department of Neurologic Surgery, Children's Hospital of Pittsburgh (E.P.J., D.R.P., I.F.P.), University of Pittsburgh, School of Medicine (E.P.J., D.R.P., J.M.C., P.A.S., T.R., I.F.P), and University of Pittsburgh Brain Tumor Center (D.R.P., I.F.P.), Pittsburgh, Pennsylvania daniel.premkumar@chp.edu ian.pollack@chp.edu., Cavaleri JM; Department of Neurologic Surgery, Children's Hospital of Pittsburgh (E.P.J., D.R.P., I.F.P.), University of Pittsburgh, School of Medicine (E.P.J., D.R.P., J.M.C., P.A.S., T.R., I.F.P), and University of Pittsburgh Brain Tumor Center (D.R.P., I.F.P.), Pittsburgh, Pennsylvania., Sutera PA; Department of Neurologic Surgery, Children's Hospital of Pittsburgh (E.P.J., D.R.P., I.F.P.), University of Pittsburgh, School of Medicine (E.P.J., D.R.P., J.M.C., P.A.S., T.R., I.F.P), and University of Pittsburgh Brain Tumor Center (D.R.P., I.F.P.), Pittsburgh, Pennsylvania., Rajasekar T; Department of Neurologic Surgery, Children's Hospital of Pittsburgh (E.P.J., D.R.P., I.F.P.), University of Pittsburgh, School of Medicine (E.P.J., D.R.P., J.M.C., P.A.S., T.R., I.F.P), and University of Pittsburgh Brain Tumor Center (D.R.P., I.F.P.), Pittsburgh, Pennsylvania., Pollack IF; Department of Neurologic Surgery, Children's Hospital of Pittsburgh (E.P.J., D.R.P., I.F.P.), University of Pittsburgh, School of Medicine (E.P.J., D.R.P., J.M.C., P.A.S., T.R., I.F.P), and University of Pittsburgh Brain Tumor Center (D.R.P., I.F.P.), Pittsburgh, Pennsylvania daniel.premkumar@chp.edu ian.pollack@chp.edu.
Source: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2016 Feb; Vol. 356 (2), pp. 354-65. Date of Electronic Publication: 2015 Nov 19.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0376362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0103 (Electronic) Linking ISSN: 00223565 NLM ISO Abbreviation: J Pharmacol Exp Ther Subsets: MEDLINE
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