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A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing.

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Title: A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing.
Authors: Alioto TS; CNAG-CRG, Centre for Genomic Regulation, Barcelona Institute of Science and Technology (BIST), Baldiri i Reixac 4, 08028 Barcelona, Spain.; Universitat Pompeu Fabra (UPF), 08002 Barcelona, Spain., Buchhalter I; Division of Theoretical Bioinformatics, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany.; Division of Applied Bioinformatics, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany., Derdak S; CNAG-CRG, Centre for Genomic Regulation, Barcelona Institute of Science and Technology (BIST), Baldiri i Reixac 4, 08028 Barcelona, Spain.; Universitat Pompeu Fabra (UPF), 08002 Barcelona, Spain., Hutter B; Division of Applied Bioinformatics, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany., Eldridge MD; Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK., Hovig E; Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, 0424 Oslo, Norway.; Department of Informatics, University of Oslo, 0373 Oslo, Norway., Heisler LE; Ontario Institute for Cancer Research, 661 University Avenue, Suite 510, Toronto, Ontario, Canada M5G 0A3., Beck TA; Ontario Institute for Cancer Research, 661 University Avenue, Suite 510, Toronto, Ontario, Canada M5G 0A3., Simpson JT; Ontario Institute for Cancer Research, 661 University Avenue, Suite 510, Toronto, Ontario, Canada M5G 0A3., Tonon L; Synergie Lyon Cancer Foundation, Centre Léon Bérard, Cheney C, 28 rue Laennec, Lyon 69373, France., Sertier AS; Synergie Lyon Cancer Foundation, Centre Léon Bérard, Cheney C, 28 rue Laennec, Lyon 69373, France., Patch AM; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.; QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia., Jäger N; Division of Theoretical Bioinformatics, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany.; Department of Genetics, Stanford University, Mail Stop-5120, Stanford, California 94305-5120, USA., Ginsbach P; Division of Theoretical Bioinformatics, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany., Drews R; Division of Theoretical Bioinformatics, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany., Paramasivam N; Division of Theoretical Bioinformatics, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany., Kabbe R; Division of Theoretical Bioinformatics, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany., Chotewutmontri S; Genome and Proteome Core Facility, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg, 69120 Germany., Diessl N; Genome and Proteome Core Facility, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg, 69120 Germany., Previti C; Genome and Proteome Core Facility, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg, 69120 Germany., Schmidt S; Genome and Proteome Core Facility, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg, 69120 Germany., Brors B; Division of Applied Bioinformatics, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany., Feuerbach L; Division of Applied Bioinformatics, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany., Heinold M; Division of Applied Bioinformatics, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany., Gröbner S; Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Im Neuenheimer Feld 430, Heidelberg 69120, Germany., Korshunov A; Department of Neuropathology, Heidelberg University Hospital, Im Neuenheimer Feld 224, Heidelberg 69120, Germany., Tarpey PS; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK., Butler AP; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK., Hinton J; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK., Jones D; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK., Menzies A; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK., Raine K; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK., Shepherd R; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK., Stebbings L; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK., Teague JW; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK., Ribeca P; CNAG-CRG, Centre for Genomic Regulation, Barcelona Institute of Science and Technology (BIST), Baldiri i Reixac 4, 08028 Barcelona, Spain.; Universitat Pompeu Fabra (UPF), 08002 Barcelona, Spain., Giner FC; CNAG-CRG, Centre for Genomic Regulation, Barcelona Institute of Science and Technology (BIST), Baldiri i Reixac 4, 08028 Barcelona, Spain.; Universitat Pompeu Fabra (UPF), 08002 Barcelona, Spain., Beltran S; CNAG-CRG, Centre for Genomic Regulation, Barcelona Institute of Science and Technology (BIST), Baldiri i Reixac 4, 08028 Barcelona, Spain.; Universitat Pompeu Fabra (UPF), 08002 Barcelona, Spain., Raineri E; CNAG-CRG, Centre for Genomic Regulation, Barcelona Institute of Science and Technology (BIST), Baldiri i Reixac 4, 08028 Barcelona, Spain.; Universitat Pompeu Fabra (UPF), 08002 Barcelona, Spain., Dabad M; CNAG-CRG, Centre for Genomic Regulation, Barcelona Institute of Science and Technology (BIST), Baldiri i Reixac 4, 08028 Barcelona, Spain.; Universitat Pompeu Fabra (UPF), 08002 Barcelona, Spain., Heath SC; CNAG-CRG, Centre for Genomic Regulation, Barcelona Institute of Science and Technology (BIST), Baldiri i Reixac 4, 08028 Barcelona, Spain.; Universitat Pompeu Fabra (UPF), 08002 Barcelona, Spain., Gut M; CNAG-CRG, Centre for Genomic Regulation, Barcelona Institute of Science and Technology (BIST), Baldiri i Reixac 4, 08028 Barcelona, Spain.; Universitat Pompeu Fabra (UPF), 08002 Barcelona, Spain., Denroche RE; Ontario Institute for Cancer Research, 661 University Avenue, Suite 510, Toronto, Ontario, Canada M5G 0A3., Harding NJ; Ontario Institute for Cancer Research, 661 University Avenue, Suite 510, Toronto, Ontario, Canada M5G 0A3., Yamaguchi TN; Ontario Institute for Cancer Research, 661 University Avenue, Suite 510, Toronto, Ontario, Canada M5G 0A3., Fujimoto A; RIKEN Center for Integrative Medical Sciences, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan., Nakagawa H; RIKEN Center for Integrative Medical Sciences, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan., Quesada V; Universidad de Oviedo-IUOPA, C/Fernando Bongera s/n, 33006 Oviedo, Spain., Valdés-Mas R; Universidad de Oviedo-IUOPA, C/Fernando Bongera s/n, 33006 Oviedo, Spain., Nakken S; Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, 0424 Oslo, Norway., Vodák D; Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, 0424 Oslo, Norway.; The Bioinformatics Core Facility, Institute for Cancer Genetics and Informatics, Oslo University Hospital, 0310 Oslo, Norway., Bower L; Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK., Lynch AG; Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK., Anderson CL; Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.; Victorian Life Sciences Computation Initiative, The University of Melbourne, Melbourne, Victoria 3053, Australia., Waddell N; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.; QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia., Pearson JV; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.; QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia., Grimmond SM; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.; WolfsonWohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow, Scotland G61 1QH, UK., Peto M; Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon 97239-3098, USA., Spellman P; Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon 97239-3098, USA., He M; BGI-Shenzhen, Shenzhen 518083, China., Kandoth C; The Genome Institute, Washington University, St Louis, Missouri 63108, USA., Lee S; Harvard Medical School, Boston, Massachusetts 02115, USA., Zhang J; Harvard Medical School, Boston, Massachusetts 02115, USA.; MD Anderson Cancer Center, Houston, Texas 77030, USA., Létourneau L; McGill University, Montreal, Quebec, Canada QC H3A 0G4., Ma S; Center for Biomolecular Science and Engineering, University of California, Santa Cruz, California 95064, USA., Seth S; MD Anderson Cancer Center, Houston, Texas 77030, USA., Torrents D; IRB-BSC Joint Research Program on Computational Biology, Barcelona Supercomputing Center, 08034 Barcelona, Spain., Xi L; Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA., Wheeler DA; Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA., López-Otín C; Universidad de Oviedo-IUOPA, C/Fernando Bongera s/n, 33006 Oviedo, Spain., Campo E; Hematopathology Unit, Department of Pathology, Hospital Clinic, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, 08036 Barcelona, Spain., Campbell PJ; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK., Boutros PC; Synergie Lyon Cancer Foundation, Centre Léon Bérard, Cheney C, 28 rue Laennec, Lyon 69373, France.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada M5G 1L7., Puente XS; Universidad de Oviedo-IUOPA, C/Fernando Bongera s/n, 33006 Oviedo, Spain., Gerhard DS; National Cancer Institute, Office of Cancer Genomics, 31 Center Drive, 10A07, Bethesda, Maryland 20892-2580, USA., Pfister SM; Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Im Neuenheimer Feld 430, Heidelberg 69120, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany., McPherson JD; Ontario Institute for Cancer Research, 661 University Avenue, Suite 510, Toronto, Ontario, Canada M5G 0A3.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada M5G 1L7., Hudson TJ; Ontario Institute for Cancer Research, 661 University Avenue, Suite 510, Toronto, Ontario, Canada M5G 0A3.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada M5G 1L7.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada M5S 1A8., Schlesner M; Division of Theoretical Bioinformatics, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany., Lichter P; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120,Germany.; Heidelberg Center for Personalised Oncology (DKFZ-HIPO), German Cancer Research Center (DKFZ), Heidelberg, Germany., Eils R; Division of Theoretical Bioinformatics, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany.; Heidelberg Center for Personalised Oncology (DKFZ-HIPO), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg, Heidelberg 69120, Germany.; Bioquant Center, University of Heidelberg, Im Neuenheimer Feld 267, Heidelberg 69120, Germany., Jones DT; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany., Gut IG; CNAG-CRG, Centre for Genomic Regulation, Barcelona Institute of Science and Technology (BIST), Baldiri i Reixac 4, 08028 Barcelona, Spain.; Universitat Pompeu Fabra (UPF), 08002 Barcelona, Spain.
Source: Nature communications [Nat Commun] 2015 Dec 09; Vol. 6, pp. 10001. Date of Electronic Publication: 2015 Dec 09.
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing.
– Name: Author
  Label: Authors
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  Data: <searchLink fieldCode="AU" term="%22Alioto+TS%22">Alioto TS</searchLink>; CNAG-CRG, Centre for Genomic Regulation, Barcelona Institute of Science and Technology (BIST), Baldiri i Reixac 4, 08028 Barcelona, Spain.; Universitat Pompeu Fabra (UPF), 08002 Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Buchhalter+I%22">Buchhalter I</searchLink>; Division of Theoretical Bioinformatics, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany.; Division of Applied Bioinformatics, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany.<br /><searchLink fieldCode="AU" term="%22Derdak+S%22">Derdak S</searchLink>; CNAG-CRG, Centre for Genomic Regulation, Barcelona Institute of Science and Technology (BIST), Baldiri i Reixac 4, 08028 Barcelona, Spain.; Universitat Pompeu Fabra (UPF), 08002 Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Hutter+B%22">Hutter B</searchLink>; Division of Applied Bioinformatics, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany.<br /><searchLink fieldCode="AU" term="%22Eldridge+MD%22">Eldridge MD</searchLink>; Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.<br /><searchLink fieldCode="AU" term="%22Hovig+E%22">Hovig E</searchLink>; Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, 0424 Oslo, Norway.; Department of Informatics, University of Oslo, 0373 Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Heisler+LE%22">Heisler LE</searchLink>; Ontario Institute for Cancer Research, 661 University Avenue, Suite 510, Toronto, Ontario, Canada M5G 0A3.<br /><searchLink fieldCode="AU" term="%22Beck+TA%22">Beck TA</searchLink>; Ontario Institute for Cancer Research, 661 University Avenue, Suite 510, Toronto, Ontario, Canada M5G 0A3.<br /><searchLink fieldCode="AU" term="%22Simpson+JT%22">Simpson JT</searchLink>; Ontario Institute for Cancer Research, 661 University Avenue, Suite 510, Toronto, Ontario, Canada M5G 0A3.<br /><searchLink fieldCode="AU" term="%22Tonon+L%22">Tonon L</searchLink>; Synergie Lyon Cancer Foundation, Centre Léon Bérard, Cheney C, 28 rue Laennec, Lyon 69373, France.<br /><searchLink fieldCode="AU" term="%22Sertier+AS%22">Sertier AS</searchLink>; Synergie Lyon Cancer Foundation, Centre Léon Bérard, Cheney C, 28 rue Laennec, Lyon 69373, France.<br /><searchLink fieldCode="AU" term="%22Patch+AM%22">Patch AM</searchLink>; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.; QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.<br /><searchLink fieldCode="AU" term="%22Jäger+N%22">Jäger N</searchLink>; Division of Theoretical Bioinformatics, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany.; Department of Genetics, Stanford University, Mail Stop-5120, Stanford, California 94305-5120, USA.<br /><searchLink fieldCode="AU" term="%22Ginsbach+P%22">Ginsbach P</searchLink>; Division of Theoretical Bioinformatics, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany.<br /><searchLink fieldCode="AU" term="%22Drews+R%22">Drews R</searchLink>; Division of Theoretical Bioinformatics, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany.<br /><searchLink fieldCode="AU" term="%22Paramasivam+N%22">Paramasivam N</searchLink>; Division of Theoretical Bioinformatics, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany.<br /><searchLink fieldCode="AU" term="%22Kabbe+R%22">Kabbe R</searchLink>; Division of Theoretical Bioinformatics, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany.<br /><searchLink fieldCode="AU" term="%22Chotewutmontri+S%22">Chotewutmontri S</searchLink>; Genome and Proteome Core Facility, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg, 69120 Germany.<br /><searchLink fieldCode="AU" term="%22Diessl+N%22">Diessl N</searchLink>; Genome and Proteome Core Facility, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg, 69120 Germany.<br /><searchLink fieldCode="AU" term="%22Previti+C%22">Previti C</searchLink>; Genome and Proteome Core Facility, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg, 69120 Germany.<br /><searchLink fieldCode="AU" term="%22Schmidt+S%22">Schmidt S</searchLink>; Genome and Proteome Core Facility, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg, 69120 Germany.<br /><searchLink fieldCode="AU" term="%22Brors+B%22">Brors B</searchLink>; Division of Applied Bioinformatics, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany.<br /><searchLink fieldCode="AU" term="%22Feuerbach+L%22">Feuerbach L</searchLink>; Division of Applied Bioinformatics, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany.<br /><searchLink fieldCode="AU" term="%22Heinold+M%22">Heinold M</searchLink>; Division of Applied Bioinformatics, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany.<br /><searchLink fieldCode="AU" term="%22Gröbner+S%22">Gröbner S</searchLink>; Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Im Neuenheimer Feld 430, Heidelberg 69120, Germany.<br /><searchLink fieldCode="AU" term="%22Korshunov+A%22">Korshunov A</searchLink>; Department of Neuropathology, Heidelberg University Hospital, Im Neuenheimer Feld 224, Heidelberg 69120, Germany.<br /><searchLink fieldCode="AU" term="%22Tarpey+PS%22">Tarpey PS</searchLink>; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.<br /><searchLink fieldCode="AU" term="%22Butler+AP%22">Butler AP</searchLink>; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.<br /><searchLink fieldCode="AU" term="%22Hinton+J%22">Hinton J</searchLink>; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.<br /><searchLink fieldCode="AU" term="%22Jones+D%22">Jones D</searchLink>; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.<br /><searchLink fieldCode="AU" term="%22Menzies+A%22">Menzies A</searchLink>; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.<br /><searchLink fieldCode="AU" term="%22Raine+K%22">Raine K</searchLink>; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.<br /><searchLink fieldCode="AU" term="%22Shepherd+R%22">Shepherd R</searchLink>; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.<br /><searchLink fieldCode="AU" term="%22Stebbings+L%22">Stebbings L</searchLink>; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.<br /><searchLink fieldCode="AU" term="%22Teague+JW%22">Teague JW</searchLink>; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.<br /><searchLink fieldCode="AU" term="%22Ribeca+P%22">Ribeca P</searchLink>; CNAG-CRG, Centre for Genomic Regulation, Barcelona Institute of Science and Technology (BIST), Baldiri i Reixac 4, 08028 Barcelona, Spain.; Universitat Pompeu Fabra (UPF), 08002 Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Giner+FC%22">Giner FC</searchLink>; CNAG-CRG, Centre for Genomic Regulation, Barcelona Institute of Science and Technology (BIST), Baldiri i Reixac 4, 08028 Barcelona, Spain.; Universitat Pompeu Fabra (UPF), 08002 Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Beltran+S%22">Beltran S</searchLink>; CNAG-CRG, Centre for Genomic Regulation, Barcelona Institute of Science and Technology (BIST), Baldiri i Reixac 4, 08028 Barcelona, Spain.; Universitat Pompeu Fabra (UPF), 08002 Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Raineri+E%22">Raineri E</searchLink>; CNAG-CRG, Centre for Genomic Regulation, Barcelona Institute of Science and Technology (BIST), Baldiri i Reixac 4, 08028 Barcelona, Spain.; Universitat Pompeu Fabra (UPF), 08002 Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Dabad+M%22">Dabad M</searchLink>; CNAG-CRG, Centre for Genomic Regulation, Barcelona Institute of Science and Technology (BIST), Baldiri i Reixac 4, 08028 Barcelona, Spain.; Universitat Pompeu Fabra (UPF), 08002 Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Heath+SC%22">Heath SC</searchLink>; CNAG-CRG, Centre for Genomic Regulation, Barcelona Institute of Science and Technology (BIST), Baldiri i Reixac 4, 08028 Barcelona, Spain.; Universitat Pompeu Fabra (UPF), 08002 Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Gut+M%22">Gut M</searchLink>; CNAG-CRG, Centre for Genomic Regulation, Barcelona Institute of Science and Technology (BIST), Baldiri i Reixac 4, 08028 Barcelona, Spain.; Universitat Pompeu Fabra (UPF), 08002 Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Denroche+RE%22">Denroche RE</searchLink>; Ontario Institute for Cancer Research, 661 University Avenue, Suite 510, Toronto, Ontario, Canada M5G 0A3.<br /><searchLink fieldCode="AU" term="%22Harding+NJ%22">Harding NJ</searchLink>; Ontario Institute for Cancer Research, 661 University Avenue, Suite 510, Toronto, Ontario, Canada M5G 0A3.<br /><searchLink fieldCode="AU" term="%22Yamaguchi+TN%22">Yamaguchi TN</searchLink>; Ontario Institute for Cancer Research, 661 University Avenue, Suite 510, Toronto, Ontario, Canada M5G 0A3.<br /><searchLink fieldCode="AU" term="%22Fujimoto+A%22">Fujimoto A</searchLink>; RIKEN Center for Integrative Medical Sciences, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.<br /><searchLink fieldCode="AU" term="%22Nakagawa+H%22">Nakagawa H</searchLink>; RIKEN Center for Integrative Medical Sciences, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.<br /><searchLink fieldCode="AU" term="%22Quesada+V%22">Quesada V</searchLink>; Universidad de Oviedo-IUOPA, C/Fernando Bongera s/n, 33006 Oviedo, Spain.<br /><searchLink fieldCode="AU" term="%22Valdés-Mas+R%22">Valdés-Mas R</searchLink>; Universidad de Oviedo-IUOPA, C/Fernando Bongera s/n, 33006 Oviedo, Spain.<br /><searchLink fieldCode="AU" term="%22Nakken+S%22">Nakken S</searchLink>; Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, 0424 Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Vodák+D%22">Vodák D</searchLink>; Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, 0424 Oslo, Norway.; The Bioinformatics Core Facility, Institute for Cancer Genetics and Informatics, Oslo University Hospital, 0310 Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Bower+L%22">Bower L</searchLink>; Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.<br /><searchLink fieldCode="AU" term="%22Lynch+AG%22">Lynch AG</searchLink>; Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.<br /><searchLink fieldCode="AU" term="%22Anderson+CL%22">Anderson CL</searchLink>; Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.; Victorian Life Sciences Computation Initiative, The University of Melbourne, Melbourne, Victoria 3053, Australia.<br /><searchLink fieldCode="AU" term="%22Waddell+N%22">Waddell N</searchLink>; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.; QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.<br /><searchLink fieldCode="AU" term="%22Pearson+JV%22">Pearson JV</searchLink>; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.; QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.<br /><searchLink fieldCode="AU" term="%22Grimmond+SM%22">Grimmond SM</searchLink>; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.; 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McGill University, Montreal, Quebec, Canada QC H3A 0G4.<br /><searchLink fieldCode="AU" term="%22Ma+S%22">Ma S</searchLink>; Center for Biomolecular Science and Engineering, University of California, Santa Cruz, California 95064, USA.<br /><searchLink fieldCode="AU" term="%22Seth+S%22">Seth S</searchLink>; MD Anderson Cancer Center, Houston, Texas 77030, USA.<br /><searchLink fieldCode="AU" term="%22Torrents+D%22">Torrents D</searchLink>; IRB-BSC Joint Research Program on Computational Biology, Barcelona Supercomputing Center, 08034 Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Xi+L%22">Xi L</searchLink>; Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA.<br /><searchLink fieldCode="AU" term="%22Wheeler+DA%22">Wheeler DA</searchLink>; Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA.<br /><searchLink fieldCode="AU" term="%22López-Otín+C%22">López-Otín C</searchLink>; Universidad de Oviedo-IUOPA, C/Fernando Bongera s/n, 33006 Oviedo, Spain.<br /><searchLink fieldCode="AU" term="%22Campo+E%22">Campo E</searchLink>; Hematopathology Unit, Department of Pathology, Hospital Clinic, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, 08036 Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Campbell+PJ%22">Campbell PJ</searchLink>; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.<br /><searchLink fieldCode="AU" term="%22Boutros+PC%22">Boutros PC</searchLink>; Synergie Lyon Cancer Foundation, Centre Léon Bérard, Cheney C, 28 rue Laennec, Lyon 69373, France.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada M5G 1L7.<br /><searchLink fieldCode="AU" term="%22Puente+XS%22">Puente XS</searchLink>; Universidad de Oviedo-IUOPA, C/Fernando Bongera s/n, 33006 Oviedo, Spain.<br /><searchLink fieldCode="AU" term="%22Gerhard+DS%22">Gerhard DS</searchLink>; National Cancer Institute, Office of Cancer Genomics, 31 Center Drive, 10A07, Bethesda, Maryland 20892-2580, USA.<br /><searchLink fieldCode="AU" term="%22Pfister+SM%22">Pfister SM</searchLink>; Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Im Neuenheimer Feld 430, Heidelberg 69120, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.<br /><searchLink fieldCode="AU" term="%22McPherson+JD%22">McPherson JD</searchLink>; Ontario Institute for Cancer Research, 661 University Avenue, Suite 510, Toronto, Ontario, Canada M5G 0A3.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada M5G 1L7.<br /><searchLink fieldCode="AU" term="%22Hudson+TJ%22">Hudson TJ</searchLink>; Ontario Institute for Cancer Research, 661 University Avenue, Suite 510, Toronto, Ontario, Canada M5G 0A3.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada M5G 1L7.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada M5S 1A8.<br /><searchLink fieldCode="AU" term="%22Schlesner+M%22">Schlesner M</searchLink>; Division of Theoretical Bioinformatics, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany.<br /><searchLink fieldCode="AU" term="%22Lichter+P%22">Lichter P</searchLink>; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120,Germany.; Heidelberg Center for Personalised Oncology (DKFZ-HIPO), German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Eils+R%22">Eils R</searchLink>; Division of Theoretical Bioinformatics, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany.; Heidelberg Center for Personalised Oncology (DKFZ-HIPO), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg, Heidelberg 69120, Germany.; Bioquant Center, University of Heidelberg, Im Neuenheimer Feld 267, Heidelberg 69120, Germany.<br /><searchLink fieldCode="AU" term="%22Jones+DT%22">Jones DT</searchLink>; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.<br /><searchLink fieldCode="AU" term="%22Gut+IG%22">Gut IG</searchLink>; CNAG-CRG, Centre for Genomic Regulation, Barcelona Institute of Science and Technology (BIST), Baldiri i Reixac 4, 08028 Barcelona, Spain.; Universitat Pompeu Fabra (UPF), 08002 Barcelona, Spain.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2015 Dec 09; Vol. 6, pp. 10001. <i>Date of Electronic Publication: </i>2015 Dec 09.
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