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Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice.

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Title: Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice.
Authors: Chang J; Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.; Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA., Wang Y; Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.; Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.; Institute of Radiation Medicine, Peking Union Medical College (PUMC), Chinese Academy of Medical Sciences (CAMS), Tianjin, China., Shao L; Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.; Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA., Laberge RM; Buck Institute for Research on Aging, Novato, California, USA., Demaria M; Buck Institute for Research on Aging, Novato, California, USA., Campisi J; Buck Institute for Research on Aging, Novato, California, USA.; Lawrence Berkeley National Laboratory, Berkeley, California, USA., Janakiraman K; Department of Medicine and Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Sharpless NE; Department of Medicine and Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Ding S; Gladstone Institute of Cardiovascular Disease, San Francisco, California, USA., Feng W; Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.; Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA., Luo Y; Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.; Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA., Wang X; Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.; Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA., Aykin-Burns N; Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.; Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA., Krager K; Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.; Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA., Ponnappan U; Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA., Hauer-Jensen M; Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.; Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA., Meng A; Institute of Radiation Medicine, Peking Union Medical College (PUMC), Chinese Academy of Medical Sciences (CAMS), Tianjin, China., Zhou D; Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.; Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Source: Nature medicine [Nat Med] 2016 Jan; Vol. 22 (1), pp. 78-83. Date of Electronic Publication: 2015 Dec 14.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice.
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  Data: <searchLink fieldCode="AU" term="%22Chang+J%22">Chang J</searchLink>; Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.; Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.; Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.; Institute of Radiation Medicine, Peking Union Medical College (PUMC), Chinese Academy of Medical Sciences (CAMS), Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Shao+L%22">Shao L</searchLink>; Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.; Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.<br /><searchLink fieldCode="AU" term="%22Laberge+RM%22">Laberge RM</searchLink>; Buck Institute for Research on Aging, Novato, California, USA.<br /><searchLink fieldCode="AU" term="%22Demaria+M%22">Demaria M</searchLink>; Buck Institute for Research on Aging, Novato, California, USA.<br /><searchLink fieldCode="AU" term="%22Campisi+J%22">Campisi J</searchLink>; Buck Institute for Research on Aging, Novato, California, USA.; Lawrence Berkeley National Laboratory, Berkeley, California, USA.<br /><searchLink fieldCode="AU" term="%22Janakiraman+K%22">Janakiraman K</searchLink>; Department of Medicine and Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Sharpless+NE%22">Sharpless NE</searchLink>; Department of Medicine and Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Ding+S%22">Ding S</searchLink>; Gladstone Institute of Cardiovascular Disease, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Feng+W%22">Feng W</searchLink>; Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.; Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.<br /><searchLink fieldCode="AU" term="%22Luo+Y%22">Luo Y</searchLink>; Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.; Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.; Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.<br /><searchLink fieldCode="AU" term="%22Aykin-Burns+N%22">Aykin-Burns N</searchLink>; Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.; Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.<br /><searchLink fieldCode="AU" term="%22Krager+K%22">Krager K</searchLink>; Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.; Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.<br /><searchLink fieldCode="AU" term="%22Ponnappan+U%22">Ponnappan U</searchLink>; Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.<br /><searchLink fieldCode="AU" term="%22Hauer-Jensen+M%22">Hauer-Jensen M</searchLink>; Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.; Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.<br /><searchLink fieldCode="AU" term="%22Meng+A%22">Meng A</searchLink>; Institute of Radiation Medicine, Peking Union Medical College (PUMC), Chinese Academy of Medical Sciences (CAMS), Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Zhou+D%22">Zhou D</searchLink>; Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.; Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
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  Data: <searchLink fieldCode="JN" term="%229502015%22">Nature medicine</searchLink> [Nat Med] 2016 Jan; Vol. 22 (1), pp. 78-83. <i>Date of Electronic Publication: </i>2015 Dec 14.
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