Hydroxycarbamide versus chronic transfusion for maintenance of transcranial doppler flow velocities in children with sickle cell anaemia-TCD With Transfusions Changing to Hydroxyurea (TWiTCH): a multicentre, open-label, phase 3, non-inferiority trial.

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Title: Hydroxycarbamide versus chronic transfusion for maintenance of transcranial doppler flow velocities in children with sickle cell anaemia-TCD With Transfusions Changing to Hydroxyurea (TWiTCH): a multicentre, open-label, phase 3, non-inferiority trial.
Authors: Ware RE; Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Electronic address: russell.ware@cchmc.org., Davis BR; University of Texas School of Public Health, Houston, TX, USA., Schultz WH; Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Brown RC; Emory University, Atlanta, GA, USA., Aygun B; Cohen Children's Medical Center, New Hyde Park, NY, USA., Sarnaik S; Wayne State University, Detroit, MI, USA., Odame I; Hospital for Sick Children, Toronto, ON, Canada., Fuh B; East Carolina University, Greenville, NC, USA., George A; Baylor College of Medicine, Houston, TX, USA., Owen W; Children's Hospital of the King's Daughters, Norfolk, VA, USA., Luchtman-Jones L; Children's National Medical Center, Washington, DC, USA., Rogers ZR; UT Southwestern, Dallas, TX, USA., Hilliard L; University of Alabama, Birmingham, AL, USA., Gauger C; Nemours Children's Clinic, Jacksonville, FL, USA., Piccone C; Case Western Reserve University, Cleveland, OH, USA., Lee MT; Columbia University, New York, NY, USA., Kwiatkowski JL; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Jackson S; Medical University of South Carolina, Charleston, SC, USA., Miller ST; State University of New York-Downstate, Brooklyn, NY, USA., Roberts C; University of South Carolina, Columbia, SC, USA., Heeney MM; Boston Children's Hospital, Boston, MA, USA., Kalfa TA; Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Nelson S; Children's Hospitals and Clinics of Minnesota, Minneapolis, MN, USA., Imran H; University of South Alabama, Mobile, AL, USA., Nottage K; St Jude Children's Research Hospital, Memphis, TN, USA., Alvarez O; University of Miami, Miami, FL, USA., Rhodes M; University of Mississippi, Jackson, MS, USA., Thompson AA; Ann and Robert H Lurie Children's Hospital of Chicago, Chicago, IL, USA., Rothman JA; Duke University Medical Center, Durham, NC, USA., Helton KJ; St Jude Children's Research Hospital, Memphis, TN, USA., Roberts D; Medical University of South Carolina, Charleston, SC, USA., Coleman J; St Jude Children's Research Hospital, Memphis, TN, USA., Bonner MJ; Duke University Medical Center, Durham, NC, USA., Kutlar A; Georgia Regents University, Augusta, GA, USA., Patel N; Georgia Regents University, Augusta, GA, USA., Wood J; Children's Hospital of Los Angeles, Los Angeles, CA, USA., Piller L; University of Texas School of Public Health, Houston, TX, USA., Wei P; University of Texas School of Public Health, Houston, TX, USA., Luden J; Medical University of South Carolina, Charleston, SC, USA., Mortier NA; Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Stuber SE; Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Luban NLC; Children's National Medical Center, Washington, DC, USA., Cohen AR; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Pressel S; University of Texas School of Public Health, Houston, TX, USA., Adams RJ; Medical University of South Carolina, Charleston, SC, USA.
Source: Lancet (London, England) [Lancet] 2016 Feb 13; Vol. 387 (10019), pp. 661-670. Date of Electronic Publication: 2015 Dec 06.
Publication Type: Clinical Trial, Phase III; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 2985213R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-547X (Electronic) Linking ISSN: 01406736 NLM ISO Abbreviation: Lancet Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1474-547X
DOI:10.1016/S0140-6736(15)01041-7