Hydroxycarbamide versus chronic transfusion for maintenance of transcranial doppler flow velocities in children with sickle cell anaemia-TCD With Transfusions Changing to Hydroxyurea (TWiTCH): a multicentre, open-label, phase 3, non-inferiority trial.
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| Title: | Hydroxycarbamide versus chronic transfusion for maintenance of transcranial doppler flow velocities in children with sickle cell anaemia-TCD With Transfusions Changing to Hydroxyurea (TWiTCH): a multicentre, open-label, phase 3, non-inferiority trial. |
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| Authors: | Ware RE; Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Electronic address: russell.ware@cchmc.org., Davis BR; University of Texas School of Public Health, Houston, TX, USA., Schultz WH; Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Brown RC; Emory University, Atlanta, GA, USA., Aygun B; Cohen Children's Medical Center, New Hyde Park, NY, USA., Sarnaik S; Wayne State University, Detroit, MI, USA., Odame I; Hospital for Sick Children, Toronto, ON, Canada., Fuh B; East Carolina University, Greenville, NC, USA., George A; Baylor College of Medicine, Houston, TX, USA., Owen W; Children's Hospital of the King's Daughters, Norfolk, VA, USA., Luchtman-Jones L; Children's National Medical Center, Washington, DC, USA., Rogers ZR; UT Southwestern, Dallas, TX, USA., Hilliard L; University of Alabama, Birmingham, AL, USA., Gauger C; Nemours Children's Clinic, Jacksonville, FL, USA., Piccone C; Case Western Reserve University, Cleveland, OH, USA., Lee MT; Columbia University, New York, NY, USA., Kwiatkowski JL; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Jackson S; Medical University of South Carolina, Charleston, SC, USA., Miller ST; State University of New York-Downstate, Brooklyn, NY, USA., Roberts C; University of South Carolina, Columbia, SC, USA., Heeney MM; Boston Children's Hospital, Boston, MA, USA., Kalfa TA; Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Nelson S; Children's Hospitals and Clinics of Minnesota, Minneapolis, MN, USA., Imran H; University of South Alabama, Mobile, AL, USA., Nottage K; St Jude Children's Research Hospital, Memphis, TN, USA., Alvarez O; University of Miami, Miami, FL, USA., Rhodes M; University of Mississippi, Jackson, MS, USA., Thompson AA; Ann and Robert H Lurie Children's Hospital of Chicago, Chicago, IL, USA., Rothman JA; Duke University Medical Center, Durham, NC, USA., Helton KJ; St Jude Children's Research Hospital, Memphis, TN, USA., Roberts D; Medical University of South Carolina, Charleston, SC, USA., Coleman J; St Jude Children's Research Hospital, Memphis, TN, USA., Bonner MJ; Duke University Medical Center, Durham, NC, USA., Kutlar A; Georgia Regents University, Augusta, GA, USA., Patel N; Georgia Regents University, Augusta, GA, USA., Wood J; Children's Hospital of Los Angeles, Los Angeles, CA, USA., Piller L; University of Texas School of Public Health, Houston, TX, USA., Wei P; University of Texas School of Public Health, Houston, TX, USA., Luden J; Medical University of South Carolina, Charleston, SC, USA., Mortier NA; Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Stuber SE; Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Luban NLC; Children's National Medical Center, Washington, DC, USA., Cohen AR; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Pressel S; University of Texas School of Public Health, Houston, TX, USA., Adams RJ; Medical University of South Carolina, Charleston, SC, USA. |
| Source: | Lancet (London, England) [Lancet] 2016 Feb 13; Vol. 387 (10019), pp. 661-670. Date of Electronic Publication: 2015 Dec 06. |
| Publication Type: | Clinical Trial, Phase III; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural |
| Journal Info: | Publisher: Elsevier Country of Publication: England NLM ID: 2985213R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-547X (Electronic) Linking ISSN: 01406736 NLM ISO Abbreviation: Lancet Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 26670617 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Hydroxycarbamide versus chronic transfusion for maintenance of transcranial doppler flow velocities in children with sickle cell anaemia-TCD With Transfusions Changing to Hydroxyurea (TWiTCH): a multicentre, open-label, phase 3, non-inferiority trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Ware+RE%22">Ware RE</searchLink>; Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Electronic address: russell.ware@cchmc.org.<br /><searchLink fieldCode="AU" term="%22Davis+BR%22">Davis BR</searchLink>; University of Texas School of Public Health, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Schultz+WH%22">Schultz WH</searchLink>; Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Brown+RC%22">Brown RC</searchLink>; Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Aygun+B%22">Aygun B</searchLink>; Cohen Children's Medical Center, New Hyde Park, NY, USA.<br /><searchLink fieldCode="AU" term="%22Sarnaik+S%22">Sarnaik S</searchLink>; Wayne State University, Detroit, MI, USA.<br /><searchLink fieldCode="AU" term="%22Odame+I%22">Odame I</searchLink>; Hospital for Sick Children, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Fuh+B%22">Fuh B</searchLink>; East Carolina University, Greenville, NC, USA.<br /><searchLink fieldCode="AU" term="%22George+A%22">George A</searchLink>; Baylor College of Medicine, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Owen+W%22">Owen W</searchLink>; Children's Hospital of the King's Daughters, Norfolk, VA, USA.<br /><searchLink fieldCode="AU" term="%22Luchtman-Jones+L%22">Luchtman-Jones L</searchLink>; Children's National Medical Center, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Rogers+ZR%22">Rogers ZR</searchLink>; UT Southwestern, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Hilliard+L%22">Hilliard L</searchLink>; University of Alabama, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Gauger+C%22">Gauger C</searchLink>; Nemours Children's Clinic, Jacksonville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Piccone+C%22">Piccone C</searchLink>; Case Western Reserve University, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Lee+MT%22">Lee MT</searchLink>; Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Kwiatkowski+JL%22">Kwiatkowski JL</searchLink>; Children's Hospital of Philadelphia, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Jackson+S%22">Jackson S</searchLink>; Medical University of South Carolina, Charleston, SC, USA.<br /><searchLink fieldCode="AU" term="%22Miller+ST%22">Miller ST</searchLink>; State University of New York-Downstate, Brooklyn, NY, USA.<br /><searchLink fieldCode="AU" term="%22Roberts+C%22">Roberts C</searchLink>; University of South Carolina, Columbia, SC, USA.<br /><searchLink fieldCode="AU" term="%22Heeney+MM%22">Heeney MM</searchLink>; Boston Children's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kalfa+TA%22">Kalfa TA</searchLink>; Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Nelson+S%22">Nelson S</searchLink>; Children's Hospitals and Clinics of Minnesota, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Imran+H%22">Imran H</searchLink>; University of South Alabama, Mobile, AL, USA.<br /><searchLink fieldCode="AU" term="%22Nottage+K%22">Nottage K</searchLink>; St Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Alvarez+O%22">Alvarez O</searchLink>; University of Miami, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Rhodes+M%22">Rhodes M</searchLink>; University of Mississippi, Jackson, MS, USA.<br /><searchLink fieldCode="AU" term="%22Thompson+AA%22">Thompson AA</searchLink>; Ann and Robert H Lurie Children's Hospital of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Rothman+JA%22">Rothman JA</searchLink>; Duke University Medical Center, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Helton+KJ%22">Helton KJ</searchLink>; St Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Roberts+D%22">Roberts D</searchLink>; Medical University of South Carolina, Charleston, SC, USA.<br /><searchLink fieldCode="AU" term="%22Coleman+J%22">Coleman J</searchLink>; St Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Bonner+MJ%22">Bonner MJ</searchLink>; Duke University Medical Center, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Kutlar+A%22">Kutlar A</searchLink>; Georgia Regents University, Augusta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Patel+N%22">Patel N</searchLink>; Georgia Regents University, Augusta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Wood+J%22">Wood J</searchLink>; Children's Hospital of Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Piller+L%22">Piller L</searchLink>; University of Texas School of Public Health, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Wei+P%22">Wei P</searchLink>; University of Texas School of Public Health, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Luden+J%22">Luden J</searchLink>; Medical University of South Carolina, Charleston, SC, USA.<br /><searchLink fieldCode="AU" term="%22Mortier+NA%22">Mortier NA</searchLink>; Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Stuber+SE%22">Stuber SE</searchLink>; Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Luban+NLC%22">Luban NLC</searchLink>; Children's National Medical Center, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Cohen+AR%22">Cohen AR</searchLink>; Children's Hospital of Philadelphia, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Pressel+S%22">Pressel S</searchLink>; University of Texas School of Public Health, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Adams+RJ%22">Adams RJ</searchLink>; Medical University of South Carolina, Charleston, SC, USA. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%222985213R%22">Lancet (London, England)</searchLink> [Lancet] 2016 Feb 13; Vol. 387 (10019), pp. 661-670. <i>Date of Electronic Publication: </i>2015 Dec 06. – Name: TypePub Label: Publication Type Group: TypPub Data: Clinical Trial, Phase III; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>2985213R <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1474-547X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201406736%22">01406736 </searchLink><i>NLM ISO Abbreviation: </i>Lancet <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=26670617 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/S0140-6736(15)01041-7 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 661 Titles: – TitleFull: Hydroxycarbamide versus chronic transfusion for maintenance of transcranial doppler flow velocities in children with sickle cell anaemia-TCD With Transfusions Changing to Hydroxyurea (TWiTCH): a multicentre, open-label, phase 3, non-inferiority trial. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Ware RE – PersonEntity: Name: NameFull: Davis BR – PersonEntity: Name: NameFull: Schultz WH – PersonEntity: Name: NameFull: Brown RC – PersonEntity: Name: NameFull: Aygun B – PersonEntity: Name: NameFull: Sarnaik S – PersonEntity: Name: NameFull: Odame I – PersonEntity: Name: NameFull: Fuh B – PersonEntity: Name: NameFull: George A – PersonEntity: Name: NameFull: Owen W – PersonEntity: Name: NameFull: Luchtman-Jones L – PersonEntity: Name: NameFull: Rogers ZR – PersonEntity: Name: NameFull: Hilliard L – PersonEntity: Name: NameFull: Gauger C – PersonEntity: Name: NameFull: Piccone C – PersonEntity: Name: NameFull: Lee MT – PersonEntity: Name: NameFull: Kwiatkowski JL – PersonEntity: Name: NameFull: Jackson S – PersonEntity: Name: NameFull: Miller ST – PersonEntity: Name: NameFull: Roberts C – PersonEntity: Name: NameFull: Heeney MM – PersonEntity: Name: NameFull: Kalfa TA – PersonEntity: Name: NameFull: Nelson S – PersonEntity: Name: NameFull: Imran H – PersonEntity: Name: NameFull: Nottage K – PersonEntity: Name: NameFull: Alvarez O – PersonEntity: Name: NameFull: Rhodes M – PersonEntity: Name: NameFull: Thompson AA – PersonEntity: Name: NameFull: Rothman JA – PersonEntity: Name: NameFull: Helton KJ – PersonEntity: Name: NameFull: Roberts D – PersonEntity: Name: NameFull: Coleman J – PersonEntity: Name: NameFull: Bonner MJ – PersonEntity: Name: NameFull: Kutlar A – PersonEntity: Name: NameFull: Patel N – PersonEntity: Name: NameFull: Wood J – PersonEntity: Name: NameFull: Piller L – PersonEntity: Name: NameFull: Wei P – PersonEntity: Name: NameFull: Luden J – PersonEntity: Name: NameFull: Mortier NA – PersonEntity: Name: NameFull: Stuber SE – PersonEntity: Name: NameFull: Luban NLC – PersonEntity: Name: NameFull: Cohen AR – PersonEntity: Name: NameFull: Pressel S – PersonEntity: Name: NameFull: Adams RJ IsPartOfRelationships: – BibEntity: Dates: – D: 13 M: 02 Text: 2016 Feb 13 Type: published Y: 2016 Identifiers: – Type: issn-electronic Value: 1474-547X Numbering: – Type: volume Value: 387 – Type: issue Value: 10019 Titles: – TitleFull: Lancet (London, England) Type: main |
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