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TarO-specific inhibitors of wall teichoic acid biosynthesis restore β-lactam efficacy against methicillin-resistant staphylococci.

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Title: TarO-specific inhibitors of wall teichoic acid biosynthesis restore β-lactam efficacy against methicillin-resistant staphylococci.
Authors: Lee SH; Merck Research Laboratories, Kenilworth, NJ 07033, USA., Wang H; Merck Research Laboratories, Kenilworth, NJ 07033, USA., Labroli M; Merck Research Laboratories, West Point, PA 19486, USA., Koseoglu S; Merck Research Laboratories, Kenilworth, NJ 07033, USA., Zuck P; Merck Research Laboratories, West Point, PA 19486, USA., Mayhood T; Merck Research Laboratories, Kenilworth, NJ 07033, USA., Gill C; Merck Research Laboratories, Kenilworth, NJ 07033, USA., Mann P; Merck Research Laboratories, Kenilworth, NJ 07033, USA., Sher X; Merck Research Laboratories, Boston, MA 02115, USA., Ha S; Merck Research Laboratories, Kenilworth, NJ 07033, USA., Yang SW; Merck Research Laboratories, Kenilworth, NJ 07033, USA., Mandal M; Merck Research Laboratories, Kenilworth, NJ 07033, USA., Yang C; Merck Research Laboratories, Kenilworth, NJ 07033, USA., Liang L; Merck Research Laboratories, Kenilworth, NJ 07033, USA., Tan Z; Merck Research Laboratories, Kenilworth, NJ 07033, USA., Tawa P; Merck Research Laboratories, Kenilworth, NJ 07033, USA., Hou Y; Merck Research Laboratories, Kenilworth, NJ 07033, USA., Kuvelkar R; Merck Research Laboratories, Kenilworth, NJ 07033, USA., DeVito K; Merck Research Laboratories, Kenilworth, NJ 07033, USA., Wen X; Merck Research Laboratories, Kenilworth, NJ 07033, USA., Xiao J; Merck Research Laboratories, Kenilworth, NJ 07033, USA., Batchlett M; Merck Research Laboratories, West Point, PA 19486, USA., Balibar CJ; Merck Research Laboratories, Kenilworth, NJ 07033, USA., Liu J; Merck Research Laboratories, Kenilworth, NJ 07033, USA., Xiao J; Merck Research Laboratories, Kenilworth, NJ 07033, USA., Murgolo N; Merck Research Laboratories, Kenilworth, NJ 07033, USA., Garlisi CG; Merck Research Laboratories, Kenilworth, NJ 07033, USA., Sheth PR; Merck Research Laboratories, Kenilworth, NJ 07033, USA., Flattery A; Merck Research Laboratories, Kenilworth, NJ 07033, USA., Su J; Merck Research Laboratories, Kenilworth, NJ 07033, USA. jing.su2@merck.com christopher_tan@merck.com terry_roemer@merck.com., Tan C; Merck Research Laboratories, Kenilworth, NJ 07033, USA. jing.su2@merck.com christopher_tan@merck.com terry_roemer@merck.com., Roemer T; Merck Research Laboratories, Kenilworth, NJ 07033, USA. jing.su2@merck.com christopher_tan@merck.com terry_roemer@merck.com.
Source: Science translational medicine [Sci Transl Med] 2016 Mar 09; Vol. 8 (329), pp. 329ra32.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: TarO-specific inhibitors of wall teichoic acid biosynthesis restore β-lactam efficacy against methicillin-resistant staphylococci.
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