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Implications of Dynamic Occupancy, Binding Kinetics, and Channel Gating Kinetics for hERG Blocker Safety Assessment and Mitigation.

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Title: Implications of Dynamic Occupancy, Binding Kinetics, and Channel Gating Kinetics for hERG Blocker Safety Assessment and Mitigation.
Authors: Pearlstein RA; Novartis Institutes for Bio- Medical Research, Inc., 100 Technology Square, Cambridge, MA 02139, USA. robert.pearlstein@novartis.com., MacCannell KA, Erdemli G, Yeola S, Helmlinger G, Hu QY, Farid R, Egan W, Whitebread S, Springer C, Beck J, Wang HR, Maciejewski M, Urban L, Duca JS
Source: Current topics in medicinal chemistry [Curr Top Med Chem] 2016; Vol. 16 (16), pp. 1792-818.
Publication Type: Journal Article; Review
Journal Info: Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 101119673 Publication Model: Print Cited Medium: Internet ISSN: 1873-4294 (Electronic) Linking ISSN: 15680266 NLM ISO Abbreviation: Curr Top Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Implications of Dynamic Occupancy, Binding Kinetics, and Channel Gating Kinetics for hERG Blocker Safety Assessment and Mitigation.
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  Data: <searchLink fieldCode="AU" term="%22Pearlstein+RA%22">Pearlstein RA</searchLink>; Novartis Institutes for Bio- Medical Research, Inc., 100 Technology Square, Cambridge, MA 02139, USA. robert.pearlstein@novartis.com.<br /><searchLink fieldCode="AU" term="%22MacCannell+KA%22">MacCannell KA</searchLink><br /><searchLink fieldCode="AU" term="%22Erdemli+G%22">Erdemli G</searchLink><br /><searchLink fieldCode="AU" term="%22Yeola+S%22">Yeola S</searchLink><br /><searchLink fieldCode="AU" term="%22Helmlinger+G%22">Helmlinger G</searchLink><br /><searchLink fieldCode="AU" term="%22Hu+QY%22">Hu QY</searchLink><br /><searchLink fieldCode="AU" term="%22Farid+R%22">Farid R</searchLink><br /><searchLink fieldCode="AU" term="%22Egan+W%22">Egan W</searchLink><br /><searchLink fieldCode="AU" term="%22Whitebread+S%22">Whitebread S</searchLink><br /><searchLink fieldCode="AU" term="%22Springer+C%22">Springer C</searchLink><br /><searchLink fieldCode="AU" term="%22Beck+J%22">Beck J</searchLink><br /><searchLink fieldCode="AU" term="%22Wang+HR%22">Wang HR</searchLink><br /><searchLink fieldCode="AU" term="%22Maciejewski+M%22">Maciejewski M</searchLink><br /><searchLink fieldCode="AU" term="%22Urban+L%22">Urban L</searchLink><br /><searchLink fieldCode="AU" term="%22Duca+JS%22">Duca JS</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22101119673%22">Current topics in medicinal chemistry</searchLink> [Curr Top Med Chem] 2016; Vol. 16 (16), pp. 1792-818.
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        Value: 10.2174/1568026616666160315142156
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