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Variation at 2q35 (PNKD and TMBIM1) influences colorectal cancer risk and identifies a pleiotropic effect with inflammatory bowel disease.

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Title: Variation at 2q35 (PNKD and TMBIM1) influences colorectal cancer risk and identifies a pleiotropic effect with inflammatory bowel disease.
Authors: Orlando G; Division of Genetics and Epidemiology, The Institute of Cancer Research, London SW7 3RP, UK., Law PJ; Division of Genetics and Epidemiology, The Institute of Cancer Research, London SW7 3RP, UK., Palin K; Genome-Scale Biology Research Program, Research Programs Unit Department of Medical and Clinical Genetics, Medicum., Tuupanen S; Genome-Scale Biology Research Program, Research Programs Unit Department of Medical and Clinical Genetics, Medicum., Gylfe A; Genome-Scale Biology Research Program, Research Programs Unit Department of Medical and Clinical Genetics, Medicum., Hänninen UA; Genome-Scale Biology Research Program, Research Programs Unit Department of Medical and Clinical Genetics, Medicum., Cajuso T; Genome-Scale Biology Research Program, Research Programs Unit Department of Medical and Clinical Genetics, Medicum., Tanskanen T; Genome-Scale Biology Research Program, Research Programs Unit Department of Medical and Clinical Genetics, Medicum., Kondelin J; Genome-Scale Biology Research Program, Research Programs Unit Department of Medical and Clinical Genetics, Medicum., Kaasinen E; Genome-Scale Biology Research Program, Research Programs Unit Department of Medical and Clinical Genetics, Medicum., Sarin AP; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki 00014, Finland., Kaprio J; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki 00014, Finland National Institute for Health and Welfare, Helsinki 00271, Finland., Eriksson JG; Folkhälsan Research Centre, Helsinki 00250, Finland Unit of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki 00014, Finland., Rissanen H; National Institute for Health and Welfare, Helsinki 00271, Finland., Knekt P; National Institute for Health and Welfare, Helsinki 00271, Finland., Pukkala E; Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki 00130, Finland School of Health Sciences, University of Tampere, Tampere 33014, Finland., Jousilahti P; National Institute for Health and Welfare, Helsinki 00271, Finland., Salomaa V; National Institute for Health and Welfare, Helsinki 00271, Finland., Ripatti S; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki 00014, Finland., Palotie A; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki 00014, Finland Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA., Järvinen H; Department of Surgery, Helsinki University Central Hospital, Hospital District of Helsinki and Uusimaa, Helsinki 00029, Finland., Renkonen-Sinisalo L; Department of Surgery, Abdominal Center, Helsinki University Hospital, Helsinki 00029, Finland., Lepistö A; Department of Surgery, Abdominal Center, Helsinki University Hospital, Helsinki 00029, Finland., Böhm J; Department of Pathology, Central Finland Central Hospital, Jyväskylä 40620, Finland., Mecklin JP; Department of Surgery, Jyväskylä Central Hospital, University of Eastern Finland, Jyväskylä 40620, Finland., Al-Tassan NA; Department of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh 12713, Saudi Arabia., Palles C; Wellcome Trust Centre for Human Genetics and NIHR Comprehensive Biomedical Research Centre, Oxford OX3 7BN, UK., Martin L; Wellcome Trust Centre for Human Genetics and NIHR Comprehensive Biomedical Research Centre, Oxford OX3 7BN, UK., Barclay E; Wellcome Trust Centre for Human Genetics and NIHR Comprehensive Biomedical Research Centre, Oxford OX3 7BN, UK., Tenesa A; Colon Cancer Genetics Group, University of Edinburgh and MRC Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, UK The Roslin Institute, University of Edinburgh, Easter Bush, Roslin EH25 9RG, UK., Farrington S; Colon Cancer Genetics Group, University of Edinburgh and MRC Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, UK., Timofeeva MN; Colon Cancer Genetics Group, University of Edinburgh and MRC Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, UK., Meyer BF; Department of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh 12713, Saudi Arabia., Wakil SM; Department of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh 12713, Saudi Arabia., Campbell H; Centre for Population Health Sciences, University of Edinburgh, Edinburgh EH8 9AG, UK., Smith CG; Institute of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK., Idziaszczyk S; Institute of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK., Maughan TS; CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford OX3 7DQ, UK., Kaplan R; MRC Clinical Trials Unit, Aviation House, London WC2B 6NH, UK., Kerr R; Department of Oncology, Oxford Cancer Centre, Churchill Hospital., Kerr D; Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford, Oxford OX3 7LE, UK., Buchanan DD; Colorectal Oncogenomics Group, Genetic Epidemiology Laboratory, Department of Pathology Centre for Epidemiology and Biostatistics, The University of Melbourne, Melbourne, Vic. 3010, Australia., Win AK; Centre for Epidemiology and Biostatistics, The University of Melbourne, Melbourne, Vic. 3010, Australia., Hopper J; Centre for Epidemiology and Biostatistics, The University of Melbourne, Melbourne, Vic. 3010, Australia., Jenkins M; Centre for Epidemiology and Biostatistics, The University of Melbourne, Melbourne, Vic. 3010, Australia., Lindor NM; Department of Health Sciences Research, Mayo Clinic, Scottsdale, AZ 85259, USA., Newcomb PA; Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA., Gallinger S; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada., Conti D; Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA., Schumacher F; Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA., Casey G; Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA., Taipale J; Genome-Scale Biology Research Program, Research Programs Unit Department of Medical and Clinical Genetics, Medicum Department of Biosciences and Nutrition, SciLife Center, Karolinska Institute, Stockholm, SE 141 83, Sweden., Cheadle JP; Genome-Scale Biology Research Program, Research Programs Unit Genome-Scale Biology Research Program, Research Programs Unit., Dunlop MG; Colon Cancer Genetics Group, University of Edinburgh and MRC Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, UK., Tomlinson IP; Wellcome Trust Centre for Human Genetics and NIHR Comprehensive Biomedical Research Centre, Oxford OX3 7BN, UK., Aaltonen LA; Genome-Scale Biology Research Program, Research Programs Unit Department of Medical and Clinical Genetics, Medicum., Houlston RS; Division of Genetics and Epidemiology, The Institute of Cancer Research, London SW7 3RP, UK richard.houlston@icr.ac.uk.
Source: Human molecular genetics [Hum Mol Genet] 2016 Jun 01; Vol. 25 (11), pp. 2349-2359. Date of Electronic Publication: 2016 Mar 22.
Publication Type: Journal Article; Meta-Analysis
Journal Info: Publisher: IRL Press at Oxford University Press Country of Publication: England NLM ID: 9208958 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2083 (Electronic) Linking ISSN: 09646906 NLM ISO Abbreviation: Hum Mol Genet Subsets: MEDLINE
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  Data: Variation at 2q35 (PNKD and TMBIM1) influences colorectal cancer risk and identifies a pleiotropic effect with inflammatory bowel disease.
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          Name:
            NameFull: Casey G
      – PersonEntity:
          Name:
            NameFull: Taipale J
      – PersonEntity:
          Name:
            NameFull: Cheadle JP
      – PersonEntity:
          Name:
            NameFull: Dunlop MG
      – PersonEntity:
          Name:
            NameFull: Tomlinson IP
      – PersonEntity:
          Name:
            NameFull: Aaltonen LA
      – PersonEntity:
          Name:
            NameFull: Houlston RS
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 06
              Text: 2016 Jun 01
              Type: published
              Y: 2016
          Identifiers:
            – Type: issn-electronic
              Value: 1460-2083
          Numbering:
            – Type: volume
              Value: 25
            – Type: issue
              Value: 11
          Titles:
            – TitleFull: Human molecular genetics
              Type: main
ResultId 1