The ictal wavefront is the spatiotemporal source of discharges during spontaneous human seizures. - Smith EH; Liou JY; Davis TS; Merricks EM; Kellis SS; Weiss SA; Greger B; House PA; McKhann GM 2nd; Goodman RR; Emerson RG; Bateman LM; et al. (Nature communications, 2016)