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Identification of benzopyrone as a common structural feature in compounds with anti-inflammatory activity in a zebrafish phenotypic screen.

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Title: Identification of benzopyrone as a common structural feature in compounds with anti-inflammatory activity in a zebrafish phenotypic screen.
Authors: Robertson AL; The Bateson Centre, University of Sheffield, Sheffield, S10 2TN, UK Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2TN, UK Stem Cell Program and Division of Hematology/Oncology, Children's Hospital Boston, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, 02115 MA, USA., Ogryzko NV; The Bateson Centre, University of Sheffield, Sheffield, S10 2TN, UK Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2TN, UK., Henry KM; The Bateson Centre, University of Sheffield, Sheffield, S10 2TN, UK Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2TN, UK., Loynes CA; The Bateson Centre, University of Sheffield, Sheffield, S10 2TN, UK Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2TN, UK., Foulkes MJ; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2TN, UK Department of Chemistry, University of Sheffield, Sheffield, S10 2TN, UK., Meloni MM; Department of Chemistry, University of Sheffield, Sheffield, S10 2TN, UK., Wang X; Wishtech Medical Technology, Weihai, Shandong, 264200, China., Ford C; Department of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, L7 9TX, UK MRC Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing, University of Liverpool, Liverpool, L7 9TX, UK., Jackson M; Department of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, L7 9TX, UK MRC Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing, University of Liverpool, Liverpool, L7 9TX, UK., Ingham PW; Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, Singapore, 138673, Singapore., Wilson HL; The Bateson Centre, University of Sheffield, Sheffield, S10 2TN, UK Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2TN, UK., Farrow SN; Institute of Human Development, University of Manchester, Manchester, M13 9PL, UK., Solari R; Faculty of Medicine, National Heart and Lung Institute, Imperial College London, Norfolk Place, London, W2 1NY, UK., Flower RJ; William Harvey Research Institute, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK., Jones S; Department of Chemistry, University of Sheffield, Sheffield, S10 2TN, UK., Whyte MK; MRC/UoE Centre for Inflammation Research, University of Edinburgh, The Queen's Medical Research Institute, Edinburgh, EH16 4TJ, UK., Renshaw SA; The Bateson Centre, University of Sheffield, Sheffield, S10 2TN, UK Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2TN, UK MRC Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing, University of Liverpool, Liverpool, L7 9TX, UK s.a.renshaw@sheffield.ac.uk.
Source: Disease models & mechanisms [Dis Model Mech] 2016 Jun 01; Vol. 9 (6), pp. 621-32. Date of Electronic Publication: 2016 Apr 14.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Company of Biologists Ltd Country of Publication: England NLM ID: 101483332 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1754-8411 (Electronic) Linking ISSN: 17548403 NLM ISO Abbreviation: Dis Model Mech Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Identification of benzopyrone as a common structural feature in compounds with anti-inflammatory activity in a zebrafish phenotypic screen.
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  Data: <searchLink fieldCode="AU" term="%22Robertson+AL%22">Robertson AL</searchLink>; The Bateson Centre, University of Sheffield, Sheffield, S10 2TN, UK Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2TN, UK Stem Cell Program and Division of Hematology/Oncology, Children's Hospital Boston, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, 02115 MA, USA.<br /><searchLink fieldCode="AU" term="%22Ogryzko+NV%22">Ogryzko NV</searchLink>; The Bateson Centre, University of Sheffield, Sheffield, S10 2TN, UK Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2TN, UK.<br /><searchLink fieldCode="AU" term="%22Henry+KM%22">Henry KM</searchLink>; The Bateson Centre, University of Sheffield, Sheffield, S10 2TN, UK Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2TN, UK.<br /><searchLink fieldCode="AU" term="%22Loynes+CA%22">Loynes CA</searchLink>; The Bateson Centre, University of Sheffield, Sheffield, S10 2TN, UK Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2TN, UK.<br /><searchLink fieldCode="AU" term="%22Foulkes+MJ%22">Foulkes MJ</searchLink>; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2TN, UK Department of Chemistry, University of Sheffield, Sheffield, S10 2TN, UK.<br /><searchLink fieldCode="AU" term="%22Meloni+MM%22">Meloni MM</searchLink>; Department of Chemistry, University of Sheffield, Sheffield, S10 2TN, UK.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Wishtech Medical Technology, Weihai, Shandong, 264200, China.<br /><searchLink fieldCode="AU" term="%22Ford+C%22">Ford C</searchLink>; Department of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, L7 9TX, UK MRC Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing, University of Liverpool, Liverpool, L7 9TX, UK.<br /><searchLink fieldCode="AU" term="%22Jackson+M%22">Jackson M</searchLink>; Department of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, L7 9TX, UK MRC Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing, University of Liverpool, Liverpool, L7 9TX, UK.<br /><searchLink fieldCode="AU" term="%22Ingham+PW%22">Ingham PW</searchLink>; Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, Singapore, 138673, Singapore.<br /><searchLink fieldCode="AU" term="%22Wilson+HL%22">Wilson HL</searchLink>; The Bateson Centre, University of Sheffield, Sheffield, S10 2TN, UK Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2TN, UK.<br /><searchLink fieldCode="AU" term="%22Farrow+SN%22">Farrow SN</searchLink>; Institute of Human Development, University of Manchester, Manchester, M13 9PL, UK.<br /><searchLink fieldCode="AU" term="%22Solari+R%22">Solari R</searchLink>; Faculty of Medicine, National Heart and Lung Institute, Imperial College London, Norfolk Place, London, W2 1NY, UK.<br /><searchLink fieldCode="AU" term="%22Flower+RJ%22">Flower RJ</searchLink>; William Harvey Research Institute, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.<br /><searchLink fieldCode="AU" term="%22Jones+S%22">Jones S</searchLink>; Department of Chemistry, University of Sheffield, Sheffield, S10 2TN, UK.<br /><searchLink fieldCode="AU" term="%22Whyte+MK%22">Whyte MK</searchLink>; MRC/UoE Centre for Inflammation Research, University of Edinburgh, The Queen's Medical Research Institute, Edinburgh, EH16 4TJ, UK.<br /><searchLink fieldCode="AU" term="%22Renshaw+SA%22">Renshaw SA</searchLink>; The Bateson Centre, University of Sheffield, Sheffield, S10 2TN, UK Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2TN, UK MRC Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing, University of Liverpool, Liverpool, L7 9TX, UK s.a.renshaw@sheffield.ac.uk.
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