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A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease.

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Title: A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease.
Authors: Scott RA; Medical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK. dawn.m.waterworth@gsk.com robert.scott@mrc-epid.cam.ac.uk nick.wareham@mrc-epid.cam.ac.uk., Freitag DF; Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge CB1 8RN, UK. The Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK., Li L; Statistical Genetics, Projects, Clinical Platforms, and Sciences (PCPS), GlaxoSmithKline, Research Triangle Park, NC 27709, USA., Chu AY; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA., Surendran P; Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge CB1 8RN, UK., Young R; Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge CB1 8RN, UK., Grarup N; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark., Stancáková A; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, FI-70211 Kuopio, Finland., Chen Y; Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA., Varga TV; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, SE-205 Malmö, Sweden., Yaghootkar H; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK., Luan J; Medical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Zhao JH; Medical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Willems SM; Medical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK. Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, 3000 CE Rotterdam, Netherlands., Wessel J; Department of Epidemiology, Fairbanks School of Public Health, Indianapolis, IN 46202, USA. Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Wang S; Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA., Maruthur N; Division of General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, MD 21205, USA. Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA., Michailidou K; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Laboratory, Worts Causeway, Cambridge CB1 8RN, UK., Pirie A; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Laboratory, Worts Causeway, Cambridge CB1 8RN, UK., van der Lee SJ; Department of Epidemiology, Erasmus University Medical Center, 3000 CA Rotterdam, Netherlands., Gillson C; Medical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Al Olama AA; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Laboratory, Worts Causeway, Cambridge CB1 8RN, UK., Amouyel P; University of Lille, INSERM, Centre Hospitalier Régional Universitaire de Lille, Institut Pasteur de Lille, UMR 1167, RID-AGE, F-59000 Lille, France., Arriola L; Public Health Division of Gipuzkoa, San Sebastian 20013, Spain. Instituto BIO-Donostia, Basque Government, San Sebastian 20014, Spain. CIBER Epidemiología y Salud Pública (CIBERESP), Madrid 28029, Spain., Arveiler D; Department of Epidemiology and Public Health (EA3430), University of Strasbourg, 67085 Strasbourg, France., Aviles-Olmos I; Sobell Department of Motor Neuroscience, UCL Institute of Neurology, London WC1N 3BG, UK., Balkau B; INSERM, Centre de Recherche en Epidémiologie et Santé des Populations (CESP), 94807 Villejuif, France. Univeristy of Paris-Sud, F-94805 Villejuif, France., Barricarte A; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid 28029, Spain. Navarre Public Health Institute (ISPN), Pamplona 31003, Spain., Barroso I; The Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK. University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge CB2 0QQ, UK., Garcia SB; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Laboratory, Worts Causeway, Cambridge CB1 8RN, UK., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA., Blankenberg S; Department of General and Interventional Cardiology, University Heart Center Hamburg, 20246 Hamburg, Germany., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109-2029, USA., Boeing H; German Institute of Human Nutrition, Potsdam-Rehbruecke, 14558 Nuthetal, Germany., Boerwinkle E; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX 77025, USA. Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA., Borecki IB; Department of Genetics, Division of Statistical Genomics, Washington University School of Medicine, St. Louis, MO 63108, USA., Bork-Jensen J; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark., Bowden S; Cancer Research UK Clinical Trials Unit, Institute for Cancer Studies, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK., Caldas C; Cancer Research UK Cambridge Institute and Department of Oncology, Li Ka Shing Centre, University of Cambridge, Cambridge CB2 0RE, UK., Caslake M; University of Glasgow, Glasgow G12 8QQ, UK., Cupples LA; Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA. Framingham Heart Study, National Heart, Lung, and Blood Institute (NHLBI), Framingham, MA 01702-5827, USA., Cruchaga C; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA., Czajkowski J; Division of Statistical Genomics, Department of Genetics and Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63108, USA., den Hoed M; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, SE-752 37 Uppsala, Sweden., Dunn JA; Warwick Clinical Trials Unit, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK., Earl HM; University of Cambridge and National Institute of Health Research Cambridge Biomedical Research Centre, Cambridge University Hospitals National Health Service Foundation Trust, Cambridge CB2 0QQ, UK., Ehret GB; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD 21205, USA., Ferrannini E; Consiglio Nazionale delle Ricerche (CNR), Institute of Clinical Physiology, 56124 Pisa, Italy., Ferrieres J; Department of Epidemiology, UMR 1027, INSERM, Centre Hospitalier Universitaire (CHU) de Toulouse, 31000 Toulouse, France., Foltynie T; Sobell Department of Motor Neuroscience, UCL Institute of Neurology, London WC1N 3BG, UK., Ford I; University of Glasgow, Glasgow G12 8QQ, UK., Forouhi NG; Medical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Gianfagna F; Department of Clinical and Experimental Medicine, Research Centre in Epidemiology and Preventive Medicine, University of Insubria, 21100 Varese, Italy. Department of Epidemiology and Prevention, Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS), Istituto Neurologico Mediterraneo Neuromed, 86077 Pozzilli, Italy., Gonzalez C; Catalan Institute of Oncology (ICO), Barcelona 08908, Spain., Grioni S; Epidemiology and Prevention Unit, 20133 Milan, Italy., Hiller L; Warwick Clinical Trials Unit, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK., Jansson JH; Research Unit, 931 41 Skellefteå, Sweden. Department of Public Health & Clinical Medicine, Umeå University, 901 85 Umeå, Sweden., Jørgensen ME; Steno Diabetes Center, 2820 Gentofte, Denmark. National Institute of Public Health, Southern Denmark University, DK-1353 Odense, Denmark., Jukema JW; Leiden University Medical Center, 2333 ZA Leiden, Netherlands., Kaaks R; German Cancer Research Centre (DKFZ), 69120 Heidelberg, Germany., Kee F; UK Clinical Research Collaboration (UKCRC) Centre of Excellence for Public Health, Queen's University Belfast, Northern Ireland, Belfast BT12 6BJ, UK., Kerrison ND; Medical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Key TJ; University of Oxford, Oxford OX1 2JD, UK., Kontto J; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Kote-Jarai Z; The Institute of Cancer Research, London SM2 5NG, UK., Kraja AT; Division of Statistical Genomics, Department of Genetics and Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63108, USA., Kuulasmaa K; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Kuusisto J; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, FI-70211 Kuopio, Finland. Kuopio University Hospital, FL 70029 Kuopio, Finland., Linneberg A; Research Centre for Prevention and Health, Capital Region, DK-2600 Copenhagen, Denmark. Department of Clinical Experimental Research, Rigshospitalet, 2100 Glostrup, Denmark. Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark., Liu C; Framingham Heart Study, Population Sciences Branch, NHLBI/National Institutes of Health (NIH), Bethesda, MD 20892, USA., Marenne G; The Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599-7264, USA., Morris AP; Department of Biostatistics, University of Liverpool, Liverpool L69 3GL, UK. Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Muir K; Centre for Epidemiology, Institute of Population Health, University of Manchester, Oxford Road, Manchester M13 9PT, UK. University of Warwick, Coventry CV4 7AL, UK., Müller-Nurasyid M; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764 Neuherberg, Germany. Department of Medicine I, Ludwig Maximilians University Munich, 80336 Munich, Germany. DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany., Munroe PB; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK., Navarro C; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid 28029, Spain. Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia 30008, Spain., Nielsen SF; Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, 2730 Copenhagen, Denmark., Nilsson PM; Lund University, 20502 Malmö, Sweden., Nordestgaard BG; Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, 2730 Copenhagen, Denmark., Packard CJ; University of Glasgow, Glasgow G12 8QQ, UK., Palli D; Cancer Research and Prevention Institute (ISPO), 50141 Florence, Italy., Panico S; Dipartimento di Medicina Clinica e Chirurgia, Federico II University, 80131 Naples, Italy., Peloso GM; Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA. Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA. Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142, USA., Perola M; National Institute for Health and Welfare, FI-00271 Helsinki, Finland. Institute of Molecular Medicine Finland (FIMM), University of Helsinki, FI-00014 Helsinki, Finland., Peters A; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany. Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764 Neuherberg, Germany., Poole CJ; University of Warwick, Coventry CV4 7AL, UK. Department of Medical Oncology, Arden Cancer Centre, University Hospital Coventry and Warwickshire, West Midlands CV2 2DX, UK., Quirós JR; Public Health Directorate, 33006 Oviedo, Asturias, Spain., Rolandsson O; Umeå University, 90187 Umeå, Sweden., Sacerdote C; Unit of Cancer Epidemiology, Citta' della Salute e della Scienza Hospital, University of Turin, 10126 Torino, Italy. Center for Cancer Prevention (CPO), 10126 Torino, Italy. Human Genetics Foundation, 10126 Torino, Italy., Salomaa V; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Sánchez MJ; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid 28029, Spain. Escuela Andaluza de Salud Pública, Instituto de Investigación Biosanitaria ibs.GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada 18012, Spain., Sattar N; University of Glasgow, Glasgow G12 8QQ, UK., Sharp SJ; Medical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Sims R; Institute of Psychological Medicine and Clinical Neuroscience, MRC Centre, Cardiff University, Cardiff CF24 4HQ, UK., Slimani N; International Agency for Research on Cancer, 69372 Lyon, France., Smith JA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109-2029, USA., Thompson DJ; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Laboratory, Worts Causeway, Cambridge CB1 8RN, UK., Trompet S; Leiden University Medical Center, 2333 ZA Leiden, Netherlands., Tumino R; Cancer Registry and Histopathology Unit, 'Civic-M.P. Arezzo' Hospital, ASP Ragusa, 97100 Ragusa, Italy., van der A DL; National Institute for Public Health and the Environment (RIVM), 3720 BA Bilthoven, Netherlands., van der Schouw YT; University Medical Center Utrecht, 3508 GA Utrecht, Netherlands., Virtamo J; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Walker M; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Walter K; The Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK., Abraham JE; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Strangeways Laboratory, Worts Causeway, Cambridge CB1 8RN, UK., Amundadottir LT; Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Aponte JL; Genetics, PCPS, GlaxoSmithKline, Research Triangle Park, NC 27709, USA., Butterworth AS; Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge CB1 8RN, UK., Dupuis J; Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA., Easton DF; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Laboratory, Worts Causeway, Cambridge CB1 8RN, UK. Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Strangeways Laboratory, Worts Causeway, Cambridge CB1 8RN, UK., Eeles RA; The Institute of Cancer Research, London SM2 5NG, UK. Royal Marsden NHS Foundation Trust, Fulham and Sutton, London and Surrey SW3 6JJ, UK., Erdmann J; Institut für Integrative und Experimentelle Genomik, Universität zu Lübeck, 23562 Lübeck, Germany., Franks PW; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, SE-205 Malmö, Sweden. Department of Public Health & Clinical Medicine, Umeå University, 901 85 Umeå, Sweden. Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA., Frayling TM; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK., Hansen T; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark., Howson JM; Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge CB1 8RN, UK., Jørgensen T; Research Centre for Prevention and Health, DK-2600 Capital Region, Denmark. Department of Public Health, Institute of Health Science, University of Copenhagen, 1014 Copenhagen, Denmark. Faculty of Medicine, Aalborg University, 9220 Aalborg, Denmark., Kooner J; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK. Imperial College Healthcare NHS Trust, London W2 1NY, UK. Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK., Laakso M; Department of Medicine, University of Kuopio, FI-70211 Kuopio, Finland., Langenberg C; Medical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., McCarthy MI; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK. Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford, Oxford, UK., Pankow JS; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55455-0381, USA., Pedersen O; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark., Riboli E; School of Public Health, Imperial College London, London W2 1PG, UK., Rotter JI; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles Medical Center, Torrance, CA 90502, USA., Saleheen D; Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA 19104, USA., Samani NJ; Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester LE3 9QP, UK. National Institute for Health Research, Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP, UK., Schunkert H; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany. Deutsches Herzzentrum München, Technische Universität München, 80636 Munich, Germany., Vollenweider P; Department of Internal Medicine, BH10-462, Internal Medicine, Lausanne University Hospital (CHUV), CH-1011 Lausanne, Switzerland., O'Rahilly S; University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge CB2 0QQ, UK. MRC Metabolic Diseases Unit, Cambridge CB2 0QQ, UK. National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK., Deloukas P; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK., Danesh J; Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge CB1 8RN, UK. The Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK., Goodarzi MO; Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA., Kathiresan S; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA. Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Cardiology Division, Center for Human Genetic Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA., Meigs JB; Division of General Internal Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA. Department of Medicine, Harvard Medical School, Boston, MA 02115, USA., Ehm MG; Genetics, PCPS, GlaxoSmithKline, Research Triangle Park, NC 27709, USA., Wareham NJ; Medical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK. dawn.m.waterworth@gsk.com robert.scott@mrc-epid.cam.ac.uk nick.wareham@mrc-epid.cam.ac.uk., Waterworth DM; Genetics, PCPS, GlaxoSmithKline, Philadelphia, PA 19104, USA. dawn.m.waterworth@gsk.com robert.scott@mrc-epid.cam.ac.uk nick.wareham@mrc-epid.cam.ac.uk.
Corporate Authors: CVD50 consortium, GERAD_EC Consortium, Neurology Working Group of the Cohorts for Heart, Aging Research in Genomic Epidemiology (CHARGE), Alzheimer’s Disease Genetics Consortium, Pancreatic Cancer Cohort Consortium, European Prospective Investigation into Cancer and Nutrition–Cardiovascular Disease (EPIC-CVD), EPIC-InterAct, CHARGE consortium, CHD Exome+ Consortium, CARDIOGRAM Exome Consortium
Source: Science translational medicine [Sci Transl Med] 2016 Jun 01; Vol. 8 (341), pp. 341ra76.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease.
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  Data: <searchLink fieldCode="AU" term="%22Scott+RA%22">Scott RA</searchLink>; Medical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK. dawn.m.waterworth@gsk.com robert.scott@mrc-epid.cam.ac.uk nick.wareham@mrc-epid.cam.ac.uk.<br /><searchLink fieldCode="AU" term="%22Freitag+DF%22">Freitag DF</searchLink>; Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge CB1 8RN, UK. The Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK.<br /><searchLink fieldCode="AU" term="%22Li+L%22">Li L</searchLink>; Statistical Genetics, Projects, Clinical Platforms, and Sciences (PCPS), GlaxoSmithKline, Research Triangle Park, NC 27709, USA.<br /><searchLink fieldCode="AU" term="%22Chu+AY%22">Chu AY</searchLink>; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Surendran+P%22">Surendran P</searchLink>; Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge CB1 8RN, UK.<br /><searchLink fieldCode="AU" term="%22Young+R%22">Young R</searchLink>; Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge CB1 8RN, UK.<br /><searchLink fieldCode="AU" term="%22Grarup+N%22">Grarup N</searchLink>; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Stancáková+A%22">Stancáková A</searchLink>; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, FI-70211 Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA.<br /><searchLink fieldCode="AU" term="%22Varga+TV%22">Varga TV</searchLink>; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, SE-205 Malmö, Sweden.<br /><searchLink fieldCode="AU" term="%22Yaghootkar+H%22">Yaghootkar H</searchLink>; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK.<br /><searchLink fieldCode="AU" term="%22Luan+J%22">Luan J</searchLink>; Medical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.<br /><searchLink fieldCode="AU" term="%22Zhao+JH%22">Zhao JH</searchLink>; Medical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.<br /><searchLink fieldCode="AU" term="%22Willems+SM%22">Willems SM</searchLink>; Medical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK. Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, 3000 CE Rotterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Wessel+J%22">Wessel J</searchLink>; Department of Epidemiology, Fairbanks School of Public Health, Indianapolis, IN 46202, USA. Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.<br /><searchLink fieldCode="AU" term="%22Wang+S%22">Wang S</searchLink>; Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA.<br /><searchLink fieldCode="AU" term="%22Maruthur+N%22">Maruthur N</searchLink>; Division of General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, MD 21205, USA. Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA.<br /><searchLink fieldCode="AU" term="%22Michailidou+K%22">Michailidou K</searchLink>; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Laboratory, Worts Causeway, Cambridge CB1 8RN, UK.<br /><searchLink fieldCode="AU" term="%22Pirie+A%22">Pirie A</searchLink>; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Laboratory, Worts Causeway, Cambridge CB1 8RN, UK.<br /><searchLink fieldCode="AU" term="%22van+der+Lee+SJ%22">van der Lee SJ</searchLink>; Department of Epidemiology, Erasmus University Medical Center, 3000 CA Rotterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Gillson+C%22">Gillson C</searchLink>; Medical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.<br /><searchLink fieldCode="AU" term="%22Al+Olama+AA%22">Al Olama AA</searchLink>; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Laboratory, Worts Causeway, Cambridge CB1 8RN, UK.<br /><searchLink fieldCode="AU" term="%22Amouyel+P%22">Amouyel P</searchLink>; University of Lille, INSERM, Centre Hospitalier Régional Universitaire de Lille, Institut Pasteur de Lille, UMR 1167, RID-AGE, F-59000 Lille, France.<br /><searchLink fieldCode="AU" term="%22Arriola+L%22">Arriola L</searchLink>; Public Health Division of Gipuzkoa, San Sebastian 20013, Spain. Instituto BIO-Donostia, Basque Government, San Sebastian 20014, Spain. CIBER Epidemiología y Salud Pública (CIBERESP), Madrid 28029, Spain.<br /><searchLink fieldCode="AU" term="%22Arveiler+D%22">Arveiler D</searchLink>; Department of Epidemiology and Public Health (EA3430), University of Strasbourg, 67085 Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Aviles-Olmos+I%22">Aviles-Olmos I</searchLink>; Sobell Department of Motor Neuroscience, UCL Institute of Neurology, London WC1N 3BG, UK.<br /><searchLink fieldCode="AU" term="%22Balkau+B%22">Balkau B</searchLink>; INSERM, Centre de Recherche en Epidémiologie et Santé des Populations (CESP), 94807 Villejuif, France. Univeristy of Paris-Sud, F-94805 Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Barricarte+A%22">Barricarte A</searchLink>; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid 28029, Spain. Navarre Public Health Institute (ISPN), Pamplona 31003, Spain.<br /><searchLink fieldCode="AU" term="%22Barroso+I%22">Barroso I</searchLink>; The Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK. University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge CB2 0QQ, UK.<br /><searchLink fieldCode="AU" term="%22Garcia+SB%22">Garcia SB</searchLink>; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Laboratory, Worts Causeway, Cambridge CB1 8RN, UK.<br /><searchLink fieldCode="AU" term="%22Bis+JC%22">Bis JC</searchLink>; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA.<br /><searchLink fieldCode="AU" term="%22Blankenberg+S%22">Blankenberg S</searchLink>; Department of General and Interventional Cardiology, University Heart Center Hamburg, 20246 Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Boehnke+M%22">Boehnke M</searchLink>; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109-2029, USA.<br /><searchLink fieldCode="AU" term="%22Boeing+H%22">Boeing H</searchLink>; German Institute of Human Nutrition, Potsdam-Rehbruecke, 14558 Nuthetal, Germany.<br /><searchLink fieldCode="AU" term="%22Boerwinkle+E%22">Boerwinkle E</searchLink>; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX 77025, USA. Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Borecki+IB%22">Borecki IB</searchLink>; Department of Genetics, Division of Statistical Genomics, Washington University School of Medicine, St. Louis, MO 63108, USA.<br /><searchLink fieldCode="AU" term="%22Bork-Jensen+J%22">Bork-Jensen J</searchLink>; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Bowden+S%22">Bowden S</searchLink>; Cancer Research UK Clinical Trials Unit, Institute for Cancer Studies, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.<br /><searchLink fieldCode="AU" term="%22Caldas+C%22">Caldas C</searchLink>; Cancer Research UK Cambridge Institute and Department of Oncology, Li Ka Shing Centre, University of Cambridge, Cambridge CB2 0RE, UK.<br /><searchLink fieldCode="AU" term="%22Caslake+M%22">Caslake M</searchLink>; University of Glasgow, Glasgow G12 8QQ, UK.<br /><searchLink fieldCode="AU" term="%22Cupples+LA%22">Cupples LA</searchLink>; Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA. Framingham Heart Study, National Heart, Lung, and Blood Institute (NHLBI), Framingham, MA 01702-5827, USA.<br /><searchLink fieldCode="AU" term="%22Cruchaga+C%22">Cruchaga C</searchLink>; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.<br /><searchLink fieldCode="AU" term="%22Czajkowski+J%22">Czajkowski J</searchLink>; Division of Statistical Genomics, Department of Genetics and Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63108, USA.<br /><searchLink fieldCode="AU" term="%22den+Hoed+M%22">den Hoed M</searchLink>; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, SE-752 37 Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Dunn+JA%22">Dunn JA</searchLink>; Warwick Clinical Trials Unit, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK.<br /><searchLink fieldCode="AU" term="%22Earl+HM%22">Earl HM</searchLink>; University of Cambridge and National Institute of Health Research Cambridge Biomedical Research Centre, Cambridge University Hospitals National Health Service Foundation Trust, Cambridge CB2 0QQ, UK.<br /><searchLink fieldCode="AU" term="%22Ehret+GB%22">Ehret GB</searchLink>; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.<br /><searchLink fieldCode="AU" term="%22Ferrannini+E%22">Ferrannini E</searchLink>; Consiglio Nazionale delle Ricerche (CNR), Institute of Clinical Physiology, 56124 Pisa, Italy.<br /><searchLink fieldCode="AU" term="%22Ferrieres+J%22">Ferrieres J</searchLink>; Department of Epidemiology, UMR 1027, INSERM, Centre Hospitalier Universitaire (CHU) de Toulouse, 31000 Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Foltynie+T%22">Foltynie T</searchLink>; Sobell Department of Motor Neuroscience, UCL Institute of Neurology, London WC1N 3BG, UK.<br /><searchLink fieldCode="AU" term="%22Ford+I%22">Ford I</searchLink>; University of Glasgow, Glasgow G12 8QQ, UK.<br /><searchLink fieldCode="AU" term="%22Forouhi+NG%22">Forouhi NG</searchLink>; Medical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.<br /><searchLink fieldCode="AU" term="%22Gianfagna+F%22">Gianfagna F</searchLink>; Department of Clinical and Experimental Medicine, Research Centre in Epidemiology and Preventive Medicine, University of Insubria, 21100 Varese, Italy. Department of Epidemiology and Prevention, Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS), Istituto Neurologico Mediterraneo Neuromed, 86077 Pozzilli, Italy.<br /><searchLink fieldCode="AU" term="%22Gonzalez+C%22">Gonzalez C</searchLink>; Catalan Institute of Oncology (ICO), Barcelona 08908, Spain.<br /><searchLink fieldCode="AU" term="%22Grioni+S%22">Grioni S</searchLink>; Epidemiology and Prevention Unit, 20133 Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Hiller+L%22">Hiller L</searchLink>; Warwick Clinical Trials Unit, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK.<br /><searchLink fieldCode="AU" term="%22Jansson+JH%22">Jansson JH</searchLink>; Research Unit, 931 41 Skellefteå, Sweden. Department of Public Health & Clinical Medicine, Umeå University, 901 85 Umeå, Sweden.<br /><searchLink fieldCode="AU" term="%22Jørgensen+ME%22">Jørgensen ME</searchLink>; Steno Diabetes Center, 2820 Gentofte, Denmark. National Institute of Public Health, Southern Denmark University, DK-1353 Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Jukema+JW%22">Jukema JW</searchLink>; Leiden University Medical Center, 2333 ZA Leiden, Netherlands.<br /><searchLink fieldCode="AU" term="%22Kaaks+R%22">Kaaks R</searchLink>; German Cancer Research Centre (DKFZ), 69120 Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Kee+F%22">Kee F</searchLink>; UK Clinical Research Collaboration (UKCRC) Centre of Excellence for Public Health, Queen's University Belfast, Northern Ireland, Belfast BT12 6BJ, UK.<br /><searchLink fieldCode="AU" term="%22Kerrison+ND%22">Kerrison ND</searchLink>; Medical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.<br /><searchLink fieldCode="AU" term="%22Key+TJ%22">Key TJ</searchLink>; University of Oxford, Oxford OX1 2JD, UK.<br /><searchLink fieldCode="AU" term="%22Kontto+J%22">Kontto J</searchLink>; National Institute for Health and Welfare, FI-00271 Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Kote-Jarai+Z%22">Kote-Jarai Z</searchLink>; The Institute of Cancer Research, London SM2 5NG, UK.<br /><searchLink fieldCode="AU" term="%22Kraja+AT%22">Kraja AT</searchLink>; Division of Statistical Genomics, Department of Genetics and Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63108, USA.<br /><searchLink fieldCode="AU" term="%22Kuulasmaa+K%22">Kuulasmaa K</searchLink>; National Institute for Health and Welfare, FI-00271 Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Kuusisto+J%22">Kuusisto J</searchLink>; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, FI-70211 Kuopio, Finland. Kuopio University Hospital, FL 70029 Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Linneberg+A%22">Linneberg A</searchLink>; Research Centre for Prevention and Health, Capital Region, DK-2600 Copenhagen, Denmark. Department of Clinical Experimental Research, Rigshospitalet, 2100 Glostrup, Denmark. Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Liu+C%22">Liu C</searchLink>; Framingham Heart Study, Population Sciences Branch, NHLBI/National Institutes of Health (NIH), Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Marenne+G%22">Marenne G</searchLink>; The Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK.<br /><searchLink fieldCode="AU" term="%22Mohlke+KL%22">Mohlke KL</searchLink>; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599-7264, USA.<br /><searchLink fieldCode="AU" term="%22Morris+AP%22">Morris AP</searchLink>; Department of Biostatistics, University of Liverpool, Liverpool L69 3GL, UK. Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.<br /><searchLink fieldCode="AU" term="%22Muir+K%22">Muir K</searchLink>; Centre for Epidemiology, Institute of Population Health, University of Manchester, Oxford Road, Manchester M13 9PT, UK. University of Warwick, Coventry CV4 7AL, UK.<br /><searchLink fieldCode="AU" term="%22Müller-Nurasyid+M%22">Müller-Nurasyid M</searchLink>; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764 Neuherberg, Germany. Department of Medicine I, Ludwig Maximilians University Munich, 80336 Munich, Germany. DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Munroe+PB%22">Munroe PB</searchLink>; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.<br /><searchLink fieldCode="AU" term="%22Navarro+C%22">Navarro C</searchLink>; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid 28029, Spain. Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia 30008, Spain.<br /><searchLink fieldCode="AU" term="%22Nielsen+SF%22">Nielsen SF</searchLink>; Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, 2730 Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Nilsson+PM%22">Nilsson PM</searchLink>; Lund University, 20502 Malmö, Sweden.<br /><searchLink fieldCode="AU" term="%22Nordestgaard+BG%22">Nordestgaard BG</searchLink>; Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, 2730 Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Packard+CJ%22">Packard CJ</searchLink>; University of Glasgow, Glasgow G12 8QQ, UK.<br /><searchLink fieldCode="AU" term="%22Palli+D%22">Palli D</searchLink>; Cancer Research and Prevention Institute (ISPO), 50141 Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Panico+S%22">Panico S</searchLink>; Dipartimento di Medicina Clinica e Chirurgia, Federico II University, 80131 Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Peloso+GM%22">Peloso GM</searchLink>; Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA. Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA. Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Perola+M%22">Perola M</searchLink>; National Institute for Health and Welfare, FI-00271 Helsinki, Finland. Institute of Molecular Medicine Finland (FIMM), University of Helsinki, FI-00014 Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Peters+A%22">Peters A</searchLink>; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany. Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764 Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Poole+CJ%22">Poole CJ</searchLink>; University of Warwick, Coventry CV4 7AL, UK. Department of Medical Oncology, Arden Cancer Centre, University Hospital Coventry and Warwickshire, West Midlands CV2 2DX, UK.<br /><searchLink fieldCode="AU" term="%22Quirós+JR%22">Quirós JR</searchLink>; Public Health Directorate, 33006 Oviedo, Asturias, Spain.<br /><searchLink fieldCode="AU" term="%22Rolandsson+O%22">Rolandsson O</searchLink>; Umeå University, 90187 Umeå, Sweden.<br /><searchLink fieldCode="AU" term="%22Sacerdote+C%22">Sacerdote C</searchLink>; Unit of Cancer Epidemiology, Citta' della Salute e della Scienza Hospital, University of Turin, 10126 Torino, Italy. Center for Cancer Prevention (CPO), 10126 Torino, Italy. Human Genetics Foundation, 10126 Torino, Italy.<br /><searchLink fieldCode="AU" term="%22Salomaa+V%22">Salomaa V</searchLink>; National Institute for Health and Welfare, FI-00271 Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Sánchez+MJ%22">Sánchez MJ</searchLink>; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid 28029, Spain. Escuela Andaluza de Salud Pública, Instituto de Investigación Biosanitaria ibs.GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada 18012, Spain.<br /><searchLink fieldCode="AU" term="%22Sattar+N%22">Sattar N</searchLink>; University of Glasgow, Glasgow G12 8QQ, UK.<br /><searchLink fieldCode="AU" term="%22Sharp+SJ%22">Sharp SJ</searchLink>; Medical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.<br /><searchLink fieldCode="AU" term="%22Sims+R%22">Sims R</searchLink>; Institute of Psychological Medicine and Clinical Neuroscience, MRC Centre, Cardiff University, Cardiff CF24 4HQ, UK.<br /><searchLink fieldCode="AU" term="%22Slimani+N%22">Slimani N</searchLink>; International Agency for Research on Cancer, 69372 Lyon, France.<br /><searchLink fieldCode="AU" term="%22Smith+JA%22">Smith JA</searchLink>; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109-2029, USA.<br /><searchLink fieldCode="AU" term="%22Thompson+DJ%22">Thompson DJ</searchLink>; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Laboratory, Worts Causeway, Cambridge CB1 8RN, UK.<br /><searchLink fieldCode="AU" term="%22Trompet+S%22">Trompet S</searchLink>; Leiden University Medical Center, 2333 ZA Leiden, Netherlands.<br /><searchLink fieldCode="AU" term="%22Tumino+R%22">Tumino R</searchLink>; Cancer Registry and Histopathology Unit, 'Civic-M.P. Arezzo' Hospital, ASP Ragusa, 97100 Ragusa, Italy.<br /><searchLink fieldCode="AU" term="%22van+der+A+DL%22">van der A DL</searchLink>; National Institute for Public Health and the Environment (RIVM), 3720 BA Bilthoven, Netherlands.<br /><searchLink fieldCode="AU" term="%22van+der+Schouw+YT%22">van der Schouw YT</searchLink>; University Medical Center Utrecht, 3508 GA Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Virtamo+J%22">Virtamo J</searchLink>; National Institute for Health and Welfare, FI-00271 Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Walker+M%22">Walker M</searchLink>; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.<br /><searchLink fieldCode="AU" term="%22Walter+K%22">Walter K</searchLink>; The Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK.<br /><searchLink fieldCode="AU" term="%22Abraham+JE%22">Abraham JE</searchLink>; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Strangeways Laboratory, Worts Causeway, Cambridge CB1 8RN, UK.<br /><searchLink fieldCode="AU" term="%22Amundadottir+LT%22">Amundadottir LT</searchLink>; Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Aponte+JL%22">Aponte JL</searchLink>; Genetics, PCPS, GlaxoSmithKline, Research Triangle Park, NC 27709, USA.<br /><searchLink fieldCode="AU" term="%22Butterworth+AS%22">Butterworth AS</searchLink>; Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge CB1 8RN, UK.<br /><searchLink fieldCode="AU" term="%22Dupuis+J%22">Dupuis J</searchLink>; Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA.<br /><searchLink fieldCode="AU" term="%22Easton+DF%22">Easton DF</searchLink>; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Laboratory, Worts Causeway, Cambridge CB1 8RN, UK. Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Strangeways Laboratory, Worts Causeway, Cambridge CB1 8RN, UK.<br /><searchLink fieldCode="AU" term="%22Eeles+RA%22">Eeles RA</searchLink>; The Institute of Cancer Research, London SM2 5NG, UK. Royal Marsden NHS Foundation Trust, Fulham and Sutton, London and Surrey SW3 6JJ, UK.<br /><searchLink fieldCode="AU" term="%22Erdmann+J%22">Erdmann J</searchLink>; Institut für Integrative und Experimentelle Genomik, Universität zu Lübeck, 23562 Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Franks+PW%22">Franks PW</searchLink>; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, SE-205 Malmö, Sweden. Department of Public Health & Clinical Medicine, Umeå University, 901 85 Umeå, Sweden. Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Frayling+TM%22">Frayling TM</searchLink>; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK.<br /><searchLink fieldCode="AU" term="%22Hansen+T%22">Hansen T</searchLink>; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Howson+JM%22">Howson JM</searchLink>; Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge CB1 8RN, UK.<br /><searchLink fieldCode="AU" term="%22Jørgensen+T%22">Jørgensen T</searchLink>; Research Centre for Prevention and Health, DK-2600 Capital Region, Denmark. Department of Public Health, Institute of Health Science, University of Copenhagen, 1014 Copenhagen, Denmark. Faculty of Medicine, Aalborg University, 9220 Aalborg, Denmark.<br /><searchLink fieldCode="AU" term="%22Kooner+J%22">Kooner J</searchLink>; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK. Imperial College Healthcare NHS Trust, London W2 1NY, UK. Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.<br /><searchLink fieldCode="AU" term="%22Laakso+M%22">Laakso M</searchLink>; Department of Medicine, University of Kuopio, FI-70211 Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Langenberg+C%22">Langenberg C</searchLink>; Medical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.<br /><searchLink fieldCode="AU" term="%22McCarthy+MI%22">McCarthy MI</searchLink>; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK. Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Pankow+JS%22">Pankow JS</searchLink>; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55455-0381, USA.<br /><searchLink fieldCode="AU" term="%22Pedersen+O%22">Pedersen O</searchLink>; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Riboli+E%22">Riboli E</searchLink>; School of Public Health, Imperial College London, London W2 1PG, UK.<br /><searchLink fieldCode="AU" term="%22Rotter+JI%22">Rotter JI</searchLink>; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles Medical Center, Torrance, CA 90502, USA.<br /><searchLink fieldCode="AU" term="%22Saleheen+D%22">Saleheen D</searchLink>; Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Samani+NJ%22">Samani NJ</searchLink>; Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester LE3 9QP, UK. National Institute for Health Research, Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP, UK.<br /><searchLink fieldCode="AU" term="%22Schunkert+H%22">Schunkert H</searchLink>; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany. Deutsches Herzzentrum München, Technische Universität München, 80636 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Vollenweider+P%22">Vollenweider P</searchLink>; Department of Internal Medicine, BH10-462, Internal Medicine, Lausanne University Hospital (CHUV), CH-1011 Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22O'Rahilly+S%22">O'Rahilly S</searchLink>; University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge CB2 0QQ, UK. MRC Metabolic Diseases Unit, Cambridge CB2 0QQ, UK. National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK.<br /><searchLink fieldCode="AU" term="%22Deloukas+P%22">Deloukas P</searchLink>; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.<br /><searchLink fieldCode="AU" term="%22Danesh+J%22">Danesh J</searchLink>; Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge CB1 8RN, UK. The Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK.<br /><searchLink fieldCode="AU" term="%22Goodarzi+MO%22">Goodarzi MO</searchLink>; Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.<br /><searchLink fieldCode="AU" term="%22Kathiresan+S%22">Kathiresan S</searchLink>; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA. Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Cardiology Division, Center for Human Genetic Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.<br /><searchLink fieldCode="AU" term="%22Meigs+JB%22">Meigs JB</searchLink>; Division of General Internal Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA. Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Ehm+MG%22">Ehm MG</searchLink>; Genetics, PCPS, GlaxoSmithKline, Research Triangle Park, NC 27709, USA.<br /><searchLink fieldCode="AU" term="%22Wareham+NJ%22">Wareham NJ</searchLink>; Medical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK. dawn.m.waterworth@gsk.com robert.scott@mrc-epid.cam.ac.uk nick.wareham@mrc-epid.cam.ac.uk.<br /><searchLink fieldCode="AU" term="%22Waterworth+DM%22">Waterworth DM</searchLink>; Genetics, PCPS, GlaxoSmithKline, Philadelphia, PA 19104, USA. dawn.m.waterworth@gsk.com robert.scott@mrc-epid.cam.ac.uk nick.wareham@mrc-epid.cam.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%22101505086%22">Science translational medicine</searchLink> [Sci Transl Med] 2016 Jun 01; Vol. 8 (341), pp. 341ra76.
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        Text: English
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        StartPage: 341ra76
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      – TitleFull: A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease.
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          Name:
            NameFull: Dupuis J
      – PersonEntity:
          Name:
            NameFull: Easton DF
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          Name:
            NameFull: Eeles RA
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          Name:
            NameFull: Erdmann J
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          Name:
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          Name:
            NameFull: Frayling TM
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          Name:
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          Name:
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      – PersonEntity:
          Name:
            NameFull: Jørgensen T
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            NameFull: Kooner J
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          Name:
            NameFull: Laakso M
      – PersonEntity:
          Name:
            NameFull: Langenberg C
      – PersonEntity:
          Name:
            NameFull: McCarthy MI
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          Name:
            NameFull: Pankow JS
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          Name:
            NameFull: Pedersen O
      – PersonEntity:
          Name:
            NameFull: Riboli E
      – PersonEntity:
          Name:
            NameFull: Rotter JI
      – PersonEntity:
          Name:
            NameFull: Saleheen D
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          Name:
            NameFull: Samani NJ
      – PersonEntity:
          Name:
            NameFull: Schunkert H
      – PersonEntity:
          Name:
            NameFull: Vollenweider P
      – PersonEntity:
          Name:
            NameFull: O'Rahilly S
      – PersonEntity:
          Name:
            NameFull: Deloukas P
      – PersonEntity:
          Name:
            NameFull: Danesh J
      – PersonEntity:
          Name:
            NameFull: Goodarzi MO
      – PersonEntity:
          Name:
            NameFull: Kathiresan S
      – PersonEntity:
          Name:
            NameFull: Meigs JB
      – PersonEntity:
          Name:
            NameFull: Ehm MG
      – PersonEntity:
          Name:
            NameFull: Wareham NJ
      – PersonEntity:
          Name:
            NameFull: Waterworth DM
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 06
              Text: 2016 Jun 01
              Type: published
              Y: 2016
          Identifiers:
            – Type: issn-electronic
              Value: 1946-6242
          Numbering:
            – Type: volume
              Value: 8
            – Type: issue
              Value: 341
          Titles:
            – TitleFull: Science translational medicine
              Type: main
ResultId 1