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Implementation of mechanism of action biology-driven early drug development for children with cancer.

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Title: Implementation of mechanism of action biology-driven early drug development for children with cancer.
Authors: Pearson AD; The Institute of Cancer Research, The Royal Marsden NHS Foundation Trust, Sutton, London, UK. Electronic address: andy1pearson@btinternet.com., Herold R; Product Development Scientific Support Department, European Medicines Agency, Canary Wharf, London, UK., Rousseau R; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Copland C; Centre for English Language Teaching, University of York, UK., Bradley-Garelik B; Bristol-Myers Squibb, 5 Research Parkway, Wallingford, CT 06492, USA., Binner D; Create for Chloe and UK representative for aPODD, UK., Capdeville R; Novartis Pharma AG, Basel CH-4002, Switzerland., Caron H; Hoffman-La Roche, Basel, Switzerland; Department of Pediatric Oncology, Emma Children's Hospital/Academic Medical Center, Amsterdam, The Netherlands., Carleer J; Belgian Federal Agency for Medicines and Health Products, Brussels, Belgium., Chesler L; Division of Clinical Studies, The Institute of Cancer Research, London, UK., Geoerger B; Department of Pediatric and Adolescent Oncology, Gustave Roussy, France., Kearns P; Cancer Research UK Clinical Trials Unit (CRCTU), Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK., Marshall LV; The Institute of Cancer Research, The Royal Marsden NHS Foundation Trust, Sutton, London, UK; Children and Young People's Unit, The Royal Marsden NHS Foundation Trust, Sutton, Surrey, UK., Pfister SM; German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), and Heidelberg University Hospital, Heidelberg 69120, Germany., Schleiermacher G; U830 INSERM, Recherche Translationelle en Oncologie Pédiatrique (RTOP) and Department of Pediatric Oncology, Institut Curie, Paris, France., Skolnik J; TetraLogic Pharmaceuticals, Malvern, PA 19355, USA., Spadoni C; aPODD Foundation, London, UK., Sterba J; Department of Paediatric Oncology, Faculty of Medicine, University Hospital Brno and Masaryk University, Brno, Czech Republic; Regional Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, ICRC Brno, Brno, Czech Republic., van den Berg H; Product Development Scientific Support Department, European Medicines Agency, Canary Wharf, London, UK., Uttenreuther-Fischer M; Boehringer Ingelheim, Germany., Witt O; Clinical Cooperation Unit Pediatric Oncology (G340), German Cancer Research Center (DKFZ), Heidelberg, Germany., Norga K; Paediatric Haematology/Oncology Unit, Antwerp University Hospital, Antwerp University, Belgium., Vassal G; Department of Clinical Research, Institut Gustave Roussy, Paris-Sud University, Paris, France.
Corporate Authors: Members of Working Group 1 of the Paediatric Platform of ACCELERATE
Source: European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2016 Jul; Vol. 62, pp. 124-31. Date of Electronic Publication: 2016 May 31.
Publication Type: Journal Article; Review; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9005373 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0852 (Electronic) Linking ISSN: 09598049 NLM ISO Abbreviation: Eur J Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Implementation of mechanism of action biology-driven early drug development for children with cancer.
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  Data: <searchLink fieldCode="AU" term="%22Pearson+AD%22">Pearson AD</searchLink>; The Institute of Cancer Research, The Royal Marsden NHS Foundation Trust, Sutton, London, UK. Electronic address: andy1pearson@btinternet.com.<br /><searchLink fieldCode="AU" term="%22Herold+R%22">Herold R</searchLink>; Product Development Scientific Support Department, European Medicines Agency, Canary Wharf, London, UK.<br /><searchLink fieldCode="AU" term="%22Rousseau+R%22">Rousseau R</searchLink>; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Copland+C%22">Copland C</searchLink>; Centre for English Language Teaching, University of York, UK.<br /><searchLink fieldCode="AU" term="%22Bradley-Garelik+B%22">Bradley-Garelik B</searchLink>; Bristol-Myers Squibb, 5 Research Parkway, Wallingford, CT 06492, USA.<br /><searchLink fieldCode="AU" term="%22Binner+D%22">Binner D</searchLink>; Create for Chloe and UK representative for aPODD, UK.<br /><searchLink fieldCode="AU" term="%22Capdeville+R%22">Capdeville R</searchLink>; Novartis Pharma AG, Basel CH-4002, Switzerland.<br /><searchLink fieldCode="AU" term="%22Caron+H%22">Caron H</searchLink>; Hoffman-La Roche, Basel, Switzerland; Department of Pediatric Oncology, Emma Children's Hospital/Academic Medical Center, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Carleer+J%22">Carleer J</searchLink>; Belgian Federal Agency for Medicines and Health Products, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Chesler+L%22">Chesler L</searchLink>; Division of Clinical Studies, The Institute of Cancer Research, London, UK.<br /><searchLink fieldCode="AU" term="%22Geoerger+B%22">Geoerger B</searchLink>; Department of Pediatric and Adolescent Oncology, Gustave Roussy, France.<br /><searchLink fieldCode="AU" term="%22Kearns+P%22">Kearns P</searchLink>; Cancer Research UK Clinical Trials Unit (CRCTU), Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Marshall+LV%22">Marshall LV</searchLink>; The Institute of Cancer Research, The Royal Marsden NHS Foundation Trust, Sutton, London, UK; Children and Young People's Unit, The Royal Marsden NHS Foundation Trust, Sutton, Surrey, UK.<br /><searchLink fieldCode="AU" term="%22Pfister+SM%22">Pfister SM</searchLink>; German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), and Heidelberg University Hospital, Heidelberg 69120, Germany.<br /><searchLink fieldCode="AU" term="%22Schleiermacher+G%22">Schleiermacher G</searchLink>; U830 INSERM, Recherche Translationelle en Oncologie Pédiatrique (RTOP) and Department of Pediatric Oncology, Institut Curie, Paris, France.<br /><searchLink fieldCode="AU" term="%22Skolnik+J%22">Skolnik J</searchLink>; TetraLogic Pharmaceuticals, Malvern, PA 19355, USA.<br /><searchLink fieldCode="AU" term="%22Spadoni+C%22">Spadoni C</searchLink>; aPODD Foundation, London, UK.<br /><searchLink fieldCode="AU" term="%22Sterba+J%22">Sterba J</searchLink>; Department of Paediatric Oncology, Faculty of Medicine, University Hospital Brno and Masaryk University, Brno, Czech Republic; Regional Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, ICRC Brno, Brno, Czech Republic.<br /><searchLink fieldCode="AU" term="%22van+den+Berg+H%22">van den Berg H</searchLink>; Product Development Scientific Support Department, European Medicines Agency, Canary Wharf, London, UK.<br /><searchLink fieldCode="AU" term="%22Uttenreuther-Fischer+M%22">Uttenreuther-Fischer M</searchLink>; Boehringer Ingelheim, Germany.<br /><searchLink fieldCode="AU" term="%22Witt+O%22">Witt O</searchLink>; Clinical Cooperation Unit Pediatric Oncology (G340), German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Norga+K%22">Norga K</searchLink>; Paediatric Haematology/Oncology Unit, Antwerp University Hospital, Antwerp University, Belgium.<br /><searchLink fieldCode="AU" term="%22Vassal+G%22">Vassal G</searchLink>; Department of Clinical Research, Institut Gustave Roussy, Paris-Sud University, Paris, France.
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  Data: <searchLink fieldCode="JN" term="%229005373%22">European journal of cancer (Oxford, England : 1990)</searchLink> [Eur J Cancer] 2016 Jul; Vol. 62, pp. 124-31. <i>Date of Electronic Publication: </i>2016 May 31.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science+Ltd%22">Elsevier Science Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9005373 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1879-0852 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209598049%22">09598049 </searchLink><i>NLM ISO Abbreviation: </i>Eur J Cancer <i>Subsets: </i>MEDLINE
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