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A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity.

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Title: A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity.
Authors: Sison-Young RL; MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Sherrington Building, Ashton Street, Liverpool, L69 3GE, UK., Lauschke VM; Department of Physiology and Pharmacology, Section of Pharmacogenetics, Karolinska Institutet, SE-171 77, Stockholm, Sweden., Johann E; Early Non-Clinical Safety, Merck KGaA, Frankfurter Str. 250, 64293, Darmstadt, Germany., Alexandre E; KaLy-Cell, 20A rue du Général Leclerc, 67115, Plobsheim, France., Antherieu S; Université de Lille 2, EA 4483, Lille, France., Aerts H; Biologie Servier, 905 Rue de Saran, 45520, Gidy, France., Gerets HHJ; UCB BioPharma SPRL, Non-Clinical Development, Chemin du Foriest, 1420, Braine-l'Alleud, Belgium., Labbe G; Sanofi-Aventis Recherche and Développement, Drug Safety Evaluation, Alfortville, France., Hoët D; Sanofi-Aventis Recherche and Développement, Drug Safety Evaluation, Alfortville, France., Dorau M; Sanofi-Aventis Deutschland GmbH, R&D DSAR, Preclinical Safety FF, Industriepark Hoechst, Building H823, Room 104, 65926, Frankfurt am Main, Germany., Schofield CA; GSK, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK., Lovatt CA; GSK, David Jack Centre for R&D, Park Road, Ware, Hertfordshire, SG12 0DP, UK., Holder JC; GSK, David Jack Centre for R&D, Park Road, Ware, Hertfordshire, SG12 0DP, UK., Stahl SH; AstraZeneca, Innovative Medicines and Early Development, Drug Safety and Metabolism, ADME Transporters, Unit 310 - Darwin Building, Cambridge Science Park, Milton Road, Cambridge, CB4 0FZ, UK., Richert L; KaLy-Cell, 20A rue du Général Leclerc, 67115, Plobsheim, France.; Université de Franche-Comté, EA 4267, 25030, Besançon, France., Kitteringham NR; MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Sherrington Building, Ashton Street, Liverpool, L69 3GE, UK., Jones RP; MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Sherrington Building, Ashton Street, Liverpool, L69 3GE, UK.; North Western Hepatobiliary Unit, Aintree University Hospital NHS Foundation Trust, Longmoor Lane, Liverpool, L9 7AL, UK., Elmasry M; MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Sherrington Building, Ashton Street, Liverpool, L69 3GE, UK.; North Western Hepatobiliary Unit, Aintree University Hospital NHS Foundation Trust, Longmoor Lane, Liverpool, L9 7AL, UK., Weaver RJ; Biologie Servier, 905 Rue de Saran, 45520, Gidy, France., Hewitt PG; Early Non-Clinical Safety, Merck KGaA, Frankfurter Str. 250, 64293, Darmstadt, Germany., Ingelman-Sundberg M; Department of Physiology and Pharmacology, Section of Pharmacogenetics, Karolinska Institutet, SE-171 77, Stockholm, Sweden., Goldring CE; MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Sherrington Building, Ashton Street, Liverpool, L69 3GE, UK. chrissy@liverpool.ac.uk., Park BK; MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Sherrington Building, Ashton Street, Liverpool, L69 3GE, UK.
Source: Archives of toxicology [Arch Toxicol] 2017 Mar; Vol. 91 (3), pp. 1385-1400. Date of Electronic Publication: 2016 Jun 25.
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0738 (Electronic) Linking ISSN: 03405761 NLM ISO Abbreviation: Arch Toxicol Subsets: MEDLINE
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  Data: A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity.
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  Data: <searchLink fieldCode="AU" term="%22Sison-Young+RL%22">Sison-Young RL</searchLink>; MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Sherrington Building, Ashton Street, Liverpool, L69 3GE, UK.<br /><searchLink fieldCode="AU" term="%22Lauschke+VM%22">Lauschke VM</searchLink>; Department of Physiology and Pharmacology, Section of Pharmacogenetics, Karolinska Institutet, SE-171 77, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Johann+E%22">Johann E</searchLink>; Early Non-Clinical Safety, Merck KGaA, Frankfurter Str. 250, 64293, Darmstadt, Germany.<br /><searchLink fieldCode="AU" term="%22Alexandre+E%22">Alexandre E</searchLink>; KaLy-Cell, 20A rue du Général Leclerc, 67115, Plobsheim, France.<br /><searchLink fieldCode="AU" term="%22Antherieu+S%22">Antherieu S</searchLink>; Université de Lille 2, EA 4483, Lille, France.<br /><searchLink fieldCode="AU" term="%22Aerts+H%22">Aerts H</searchLink>; Biologie Servier, 905 Rue de Saran, 45520, Gidy, France.<br /><searchLink fieldCode="AU" term="%22Gerets+HHJ%22">Gerets HHJ</searchLink>; UCB BioPharma SPRL, Non-Clinical Development, Chemin du Foriest, 1420, Braine-l'Alleud, Belgium.<br /><searchLink fieldCode="AU" term="%22Labbe+G%22">Labbe G</searchLink>; Sanofi-Aventis Recherche and Développement, Drug Safety Evaluation, Alfortville, France.<br /><searchLink fieldCode="AU" term="%22Hoët+D%22">Hoët D</searchLink>; Sanofi-Aventis Recherche and Développement, Drug Safety Evaluation, Alfortville, France.<br /><searchLink fieldCode="AU" term="%22Dorau+M%22">Dorau M</searchLink>; Sanofi-Aventis Deutschland GmbH, R&D DSAR, Preclinical Safety FF, Industriepark Hoechst, Building H823, Room 104, 65926, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Schofield+CA%22">Schofield CA</searchLink>; GSK, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK.<br /><searchLink fieldCode="AU" term="%22Lovatt+CA%22">Lovatt CA</searchLink>; GSK, David Jack Centre for R&D, Park Road, Ware, Hertfordshire, SG12 0DP, UK.<br /><searchLink fieldCode="AU" term="%22Holder+JC%22">Holder JC</searchLink>; GSK, David Jack Centre for R&D, Park Road, Ware, Hertfordshire, SG12 0DP, UK.<br /><searchLink fieldCode="AU" term="%22Stahl+SH%22">Stahl SH</searchLink>; AstraZeneca, Innovative Medicines and Early Development, Drug Safety and Metabolism, ADME Transporters, Unit 310 - Darwin Building, Cambridge Science Park, Milton Road, Cambridge, CB4 0FZ, UK.<br /><searchLink fieldCode="AU" term="%22Richert+L%22">Richert L</searchLink>; KaLy-Cell, 20A rue du Général Leclerc, 67115, Plobsheim, France.; Université de Franche-Comté, EA 4267, 25030, Besançon, France.<br /><searchLink fieldCode="AU" term="%22Kitteringham+NR%22">Kitteringham NR</searchLink>; MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Sherrington Building, Ashton Street, Liverpool, L69 3GE, UK.<br /><searchLink fieldCode="AU" term="%22Jones+RP%22">Jones RP</searchLink>; MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Sherrington Building, Ashton Street, Liverpool, L69 3GE, UK.; North Western Hepatobiliary Unit, Aintree University Hospital NHS Foundation Trust, Longmoor Lane, Liverpool, L9 7AL, UK.<br /><searchLink fieldCode="AU" term="%22Elmasry+M%22">Elmasry M</searchLink>; MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Sherrington Building, Ashton Street, Liverpool, L69 3GE, UK.; North Western Hepatobiliary Unit, Aintree University Hospital NHS Foundation Trust, Longmoor Lane, Liverpool, L9 7AL, UK.<br /><searchLink fieldCode="AU" term="%22Weaver+RJ%22">Weaver RJ</searchLink>; Biologie Servier, 905 Rue de Saran, 45520, Gidy, France.<br /><searchLink fieldCode="AU" term="%22Hewitt+PG%22">Hewitt PG</searchLink>; Early Non-Clinical Safety, Merck KGaA, Frankfurter Str. 250, 64293, Darmstadt, Germany.<br /><searchLink fieldCode="AU" term="%22Ingelman-Sundberg+M%22">Ingelman-Sundberg M</searchLink>; Department of Physiology and Pharmacology, Section of Pharmacogenetics, Karolinska Institutet, SE-171 77, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Goldring+CE%22">Goldring CE</searchLink>; MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Sherrington Building, Ashton Street, Liverpool, L69 3GE, UK. chrissy@liverpool.ac.uk.<br /><searchLink fieldCode="AU" term="%22Park+BK%22">Park BK</searchLink>; MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Sherrington Building, Ashton Street, Liverpool, L69 3GE, UK.
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  Data: <searchLink fieldCode="JN" term="%220417615%22">Archives of toxicology</searchLink> [Arch Toxicol] 2017 Mar; Vol. 91 (3), pp. 1385-1400. <i>Date of Electronic Publication: </i>2016 Jun 25.
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