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Metronidazole Metabolism in Neonates and the Interplay Between Ontogeny and Genetic Variation.

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Title: Metronidazole Metabolism in Neonates and the Interplay Between Ontogeny and Genetic Variation.
Authors: Wang LA; Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA., Gonzalez D; Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA., Leeder JS; Department of Pediatrics, University of Missouri-Kansas City School of Medicine, Kansas City, MO, USA.; Department of Pharmacology, University of Missouri-Kansas City School of Pharmacy, Kansas City, MO, USA.; Divisions of Clinical Pharmacology, Toxicology, and Therapeutic Innovation, Children's Mercy Hospitals and Clinics, Kansas City, MO, USA., Tyndale RF; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Departments of Pharmacology & Toxicology and Psychiatry, University of Toronto, Toronto, Ontario, Canada., Pearce RE; Department of Pediatrics, University of Missouri-Kansas City School of Medicine, Kansas City, MO, USA.; Department of Pharmacology, University of Missouri-Kansas City School of Pharmacy, Kansas City, MO, USA.; Divisions of Clinical Pharmacology, Toxicology, and Therapeutic Innovation, Children's Mercy Hospitals and Clinics, Kansas City, MO, USA., Benjamin DK Jr; Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA.; Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA., Kearns GL; Arkansas Children's Hospital Research Institute and the Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Cohen-Wolkowiez M; Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA.; Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA.
Corporate Authors: Best Pharmaceuticals for Children Act-Pediatric Trials Network Steering Committee
Source: Journal of clinical pharmacology [J Clin Pharmacol] 2017 Feb; Vol. 57 (2), pp. 230-234. Date of Electronic Publication: 2016 Aug 23.
Publication Type: Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Wiley Country of Publication: England NLM ID: 0366372 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4604 (Electronic) Linking ISSN: 00912700 NLM ISO Abbreviation: J Clin Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Metronidazole Metabolism in Neonates and the Interplay Between Ontogeny and Genetic Variation.
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  Data: <searchLink fieldCode="AU" term="%22Wang+LA%22">Wang LA</searchLink>; Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Gonzalez+D%22">Gonzalez D</searchLink>; Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Leeder+JS%22">Leeder JS</searchLink>; Department of Pediatrics, University of Missouri-Kansas City School of Medicine, Kansas City, MO, USA.; Department of Pharmacology, University of Missouri-Kansas City School of Pharmacy, Kansas City, MO, USA.; Divisions of Clinical Pharmacology, Toxicology, and Therapeutic Innovation, Children's Mercy Hospitals and Clinics, Kansas City, MO, USA.<br /><searchLink fieldCode="AU" term="%22Tyndale+RF%22">Tyndale RF</searchLink>; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Departments of Pharmacology & Toxicology and Psychiatry, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Pearce+RE%22">Pearce RE</searchLink>; Department of Pediatrics, University of Missouri-Kansas City School of Medicine, Kansas City, MO, USA.; Department of Pharmacology, University of Missouri-Kansas City School of Pharmacy, Kansas City, MO, USA.; Divisions of Clinical Pharmacology, Toxicology, and Therapeutic Innovation, Children's Mercy Hospitals and Clinics, Kansas City, MO, USA.<br /><searchLink fieldCode="AU" term="%22Benjamin+DK+Jr%22">Benjamin DK Jr</searchLink>; Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA.; Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Kearns+GL%22">Kearns GL</searchLink>; Arkansas Children's Hospital Research Institute and the Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.<br /><searchLink fieldCode="AU" term="%22Cohen-Wolkowiez+M%22">Cohen-Wolkowiez M</searchLink>; Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA.; Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA.
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  Data: <searchLink fieldCode="JN" term="%220366372%22">Journal of clinical pharmacology</searchLink> [J Clin Pharmacol] 2017 Feb; Vol. 57 (2), pp. 230-234. <i>Date of Electronic Publication: </i>2016 Aug 23.
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              Text: 2017 Feb
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