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Natural underlying mtDNA heteroplasmy as a potential source of intra-person hiPSC variability.

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Title: Natural underlying mtDNA heteroplasmy as a potential source of intra-person hiPSC variability.
Authors: Perales-Clemente E; Departments of Medicine, Molecular Pharmacology and Experimental Therapeutics, and Medical Genetics, Division of Cardiovascular Diseases, Mayo Clinic Center for Regenerative Medicine, Rochester, MN, USA., Cook AN; Departments of Cardiovascular Diseases, Molecular Pharmacology and Experimental Therapeutics, Division of General Internal Medicine, Division of Pediatric Cardiology, and Transplant Center, Mayo Clinic Center for Regenerative Medicine, Rochester, MN, USA., Evans JM; Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA., Roellinger S; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., Secreto F; Departments of Cardiovascular Diseases, Molecular Pharmacology and Experimental Therapeutics, Division of General Internal Medicine, Division of Pediatric Cardiology, and Transplant Center, Mayo Clinic Center for Regenerative Medicine, Rochester, MN, USA., Emmanuele V; Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy., Oglesbee D; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., Mootha VK; Department of Molecular Biology, Howard Hughes Medical Institute Massachusetts General Hospital, Boston, MA, USA., Hirano M; Department of Neurology, Columbia University Medical Center, New York, NY, USA., Schon EA; Department of Neurology, Columbia University Medical Center, New York, NY, USA Department of Genetics and Development, Columbia University Medical Center, New York, NY, USA., Terzic A; Departments of Medicine, Molecular Pharmacology and Experimental Therapeutics, and Medical Genetics, Division of Cardiovascular Diseases, Mayo Clinic Center for Regenerative Medicine, Rochester, MN, USA., Nelson TJ; Departments of Cardiovascular Diseases, Molecular Pharmacology and Experimental Therapeutics, Division of General Internal Medicine, Division of Pediatric Cardiology, and Transplant Center, Mayo Clinic Center for Regenerative Medicine, Rochester, MN, USA nelson.timothy@mayo.edu.
Source: The EMBO journal [EMBO J] 2016 Sep 15; Vol. 35 (18), pp. 1979-90. Date of Electronic Publication: 2016 Jul 19.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Natural underlying mtDNA heteroplasmy as a potential source of intra-person hiPSC variability.
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  Data: <searchLink fieldCode="AU" term="%22Perales-Clemente+E%22">Perales-Clemente E</searchLink>; Departments of Medicine, Molecular Pharmacology and Experimental Therapeutics, and Medical Genetics, Division of Cardiovascular Diseases, Mayo Clinic Center for Regenerative Medicine, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Cook+AN%22">Cook AN</searchLink>; Departments of Cardiovascular Diseases, Molecular Pharmacology and Experimental Therapeutics, Division of General Internal Medicine, Division of Pediatric Cardiology, and Transplant Center, Mayo Clinic Center for Regenerative Medicine, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Evans+JM%22">Evans JM</searchLink>; Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Roellinger+S%22">Roellinger S</searchLink>; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Secreto+F%22">Secreto F</searchLink>; Departments of Cardiovascular Diseases, Molecular Pharmacology and Experimental Therapeutics, Division of General Internal Medicine, Division of Pediatric Cardiology, and Transplant Center, Mayo Clinic Center for Regenerative Medicine, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Emmanuele+V%22">Emmanuele V</searchLink>; Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.<br /><searchLink fieldCode="AU" term="%22Oglesbee+D%22">Oglesbee D</searchLink>; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Mootha+VK%22">Mootha VK</searchLink>; Department of Molecular Biology, Howard Hughes Medical Institute Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Hirano+M%22">Hirano M</searchLink>; Department of Neurology, Columbia University Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Schon+EA%22">Schon EA</searchLink>; Department of Neurology, Columbia University Medical Center, New York, NY, USA Department of Genetics and Development, Columbia University Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Terzic+A%22">Terzic A</searchLink>; Departments of Medicine, Molecular Pharmacology and Experimental Therapeutics, and Medical Genetics, Division of Cardiovascular Diseases, Mayo Clinic Center for Regenerative Medicine, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Nelson+TJ%22">Nelson TJ</searchLink>; Departments of Cardiovascular Diseases, Molecular Pharmacology and Experimental Therapeutics, Division of General Internal Medicine, Division of Pediatric Cardiology, and Transplant Center, Mayo Clinic Center for Regenerative Medicine, Rochester, MN, USA nelson.timothy@mayo.edu.
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