Tryptophan-rich basic protein (WRB) mediates insertion of the tail-anchored protein otoferlin and is required for hair cell exocytosis and hearing.

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Title: Tryptophan-rich basic protein (WRB) mediates insertion of the tail-anchored protein otoferlin and is required for hair cell exocytosis and hearing.
Authors: Vogl C; Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany.; Collaborative Research Center 889, University of Göttingen, Göttingen, Germany., Panou I; Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany.; Collaborative Research Center 889, University of Göttingen, Göttingen, Germany.; Göttingen Graduate School for Neurosciences, Biophysics and Molecular Biosciences, University of Göttingen, Göttingen, Germany., Yamanbaeva G; Collaborative Research Center 889, University of Göttingen, Göttingen, Germany.; Auditory Systems Physiology Group and InnerEarLab, Department of Otolaryngology, University of Göttingen Medical Center, Göttingen, Germany., Wichmann C; Collaborative Research Center 889, University of Göttingen, Göttingen, Germany.; Molecular Architecture of Synapses Group, Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany., Mangosing SJ; Otolaryngology Division, Department of Surgery, School of Medicine, University of California San Diego, La Jolla, CA, USA., Vilardi F; Institute of Molecular Biology, University Medical Center Göttingen, Göttingen, Germany., Indzhykulian AA; Howard Hughes Medical Institute and Department of Neurobiology, Harvard Medical School, Boston, MA, USA., Pangršič T; Collaborative Research Center 889, University of Göttingen, Göttingen, Germany.; Synaptic Physiology of Mammalian Vestibular Hair Cells Junior Research Group, Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany., Santarelli R; Department of Neurosciences, University of Padova, Padova, Italy.; Audiology and Phoniatrics Service, Treviso Regional Hospital, Treviso, Italy., Rodriguez-Ballesteros M; Servicio de Genetica, Hospital Universitario Ramon y Cajal, IRYCIS, Madrid, Spain., Weber T; Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany., Jung S; Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany.; Synaptic Nanophysiology Group, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany., Cardenas E; Otolaryngology Division, Department of Surgery, School of Medicine, University of California San Diego, La Jolla, CA, USA., Wu X; Howard Hughes Medical Institute and Department of Neurobiology, Harvard Medical School, Boston, MA, USA., Wojcik SM; Department of Molecular Neurobiology, Max-Planck-Institute for Experimental Medicine, Göttingen, Germany., Kwan KY; W. M. Keck Center for Collaborative Neuroscience, Nelson Lab-D250, Rutgers University, Piscataway, NJ, USA., Del Castillo I; Servicio de Genetica, Hospital Universitario Ramon y Cajal, IRYCIS, Madrid, Spain.; Centro de Investigacion Biomedica en Red de Enfermedades Raras (CIBERER), Madrid, Spain., Schwappach B; Institute of Molecular Biology, University Medical Center Göttingen, Göttingen, Germany., Strenzke N; Collaborative Research Center 889, University of Göttingen, Göttingen, Germany.; Auditory Systems Physiology Group and InnerEarLab, Department of Otolaryngology, University of Göttingen Medical Center, Göttingen, Germany., Corey DP; Howard Hughes Medical Institute and Department of Neurobiology, Harvard Medical School, Boston, MA, USA david_corey@hms.harvard.edu shuh-yow@ucsd.edu tmoser@gwdg.de., Lin SY; Otolaryngology Division, Department of Surgery, School of Medicine, University of California San Diego, La Jolla, CA, USA david_corey@hms.harvard.edu shuh-yow@ucsd.edu tmoser@gwdg.de., Moser T; Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany david_corey@hms.harvard.edu shuh-yow@ucsd.edu tmoser@gwdg.de.; Collaborative Research Center 889, University of Göttingen, Göttingen, Germany.; Synaptic Nanophysiology Group, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.; Center for Nanoscale Microscopy and Molecular Physiology of the Brain, University Medical Center Göttingen, Göttingen, Germany.
Source: The EMBO journal [EMBO J] 2016 Dec 01; Vol. 35 (23), pp. 2536-2552. Date of Electronic Publication: 2016 Jul 25.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
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  Data: Tryptophan-rich basic protein (WRB) mediates insertion of the tail-anchored protein otoferlin and is required for hair cell exocytosis and hearing.
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  Data: <searchLink fieldCode="AU" term="%22Vogl+C%22">Vogl C</searchLink>; Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany.; Collaborative Research Center 889, University of Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Panou+I%22">Panou I</searchLink>; Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany.; Collaborative Research Center 889, University of Göttingen, Göttingen, Germany.; Göttingen Graduate School for Neurosciences, Biophysics and Molecular Biosciences, University of Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Yamanbaeva+G%22">Yamanbaeva G</searchLink>; Collaborative Research Center 889, University of Göttingen, Göttingen, Germany.; Auditory Systems Physiology Group and InnerEarLab, Department of Otolaryngology, University of Göttingen Medical Center, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Wichmann+C%22">Wichmann C</searchLink>; Collaborative Research Center 889, University of Göttingen, Göttingen, Germany.; Molecular Architecture of Synapses Group, Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Mangosing+SJ%22">Mangosing SJ</searchLink>; Otolaryngology Division, Department of Surgery, School of Medicine, University of California San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Vilardi+F%22">Vilardi F</searchLink>; Institute of Molecular Biology, University Medical Center Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Indzhykulian+AA%22">Indzhykulian AA</searchLink>; Howard Hughes Medical Institute and Department of Neurobiology, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Pangršič+T%22">Pangršič T</searchLink>; Collaborative Research Center 889, University of Göttingen, Göttingen, Germany.; Synaptic Physiology of Mammalian Vestibular Hair Cells Junior Research Group, Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Santarelli+R%22">Santarelli R</searchLink>; Department of Neurosciences, University of Padova, Padova, Italy.; Audiology and Phoniatrics Service, Treviso Regional Hospital, Treviso, Italy.<br /><searchLink fieldCode="AU" term="%22Rodriguez-Ballesteros+M%22">Rodriguez-Ballesteros M</searchLink>; Servicio de Genetica, Hospital Universitario Ramon y Cajal, IRYCIS, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Weber+T%22">Weber T</searchLink>; Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Jung+S%22">Jung S</searchLink>; Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany.; Synaptic Nanophysiology Group, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Cardenas+E%22">Cardenas E</searchLink>; Otolaryngology Division, Department of Surgery, School of Medicine, University of California San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wu+X%22">Wu X</searchLink>; Howard Hughes Medical Institute and Department of Neurobiology, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wojcik+SM%22">Wojcik SM</searchLink>; Department of Molecular Neurobiology, Max-Planck-Institute for Experimental Medicine, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Kwan+KY%22">Kwan KY</searchLink>; W. 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Keck Center for Collaborative Neuroscience, Nelson Lab-D250, Rutgers University, Piscataway, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Del+Castillo+I%22">Del Castillo I</searchLink>; Servicio de Genetica, Hospital Universitario Ramon y Cajal, IRYCIS, Madrid, Spain.; Centro de Investigacion Biomedica en Red de Enfermedades Raras (CIBERER), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Schwappach+B%22">Schwappach B</searchLink>; Institute of Molecular Biology, University Medical Center Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Strenzke+N%22">Strenzke N</searchLink>; Collaborative Research Center 889, University of Göttingen, Göttingen, Germany.; Auditory Systems Physiology Group and InnerEarLab, Department of Otolaryngology, University of Göttingen Medical Center, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Corey+DP%22">Corey DP</searchLink>; Howard Hughes Medical Institute and Department of Neurobiology, Harvard Medical School, Boston, MA, USA david_corey@hms.harvard.edu shuh-yow@ucsd.edu tmoser@gwdg.de.<br /><searchLink fieldCode="AU" term="%22Lin+SY%22">Lin SY</searchLink>; Otolaryngology Division, Department of Surgery, School of Medicine, University of California San Diego, La Jolla, CA, USA david_corey@hms.harvard.edu shuh-yow@ucsd.edu tmoser@gwdg.de.<br /><searchLink fieldCode="AU" term="%22Moser+T%22">Moser T</searchLink>; Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany david_corey@hms.harvard.edu shuh-yow@ucsd.edu tmoser@gwdg.de.; Collaborative Research Center 889, University of Göttingen, Göttingen, Germany.; Synaptic Nanophysiology Group, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.; Center for Nanoscale Microscopy and Molecular Physiology of the Brain, University Medical Center Göttingen, Göttingen, Germany.
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